Results 21 to 30 of about 36,256,275 (202)

Regulation of the mammalian target of rapamycin complex 2 (mTORC2) [PDF]

, 2006
The growth controlling mammalian Target of Rapamycin (mTOR) is a conserved Ser/Thr kinase found in two structurally and functionally distinct complexes, mTORC1 and mTORC2.
Molle, Klaus-Dieter
core   +1 more source

Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1α production in sporadic clear-cell renal cell carcinoma

Experimental and Molecular Pathology, 2016
Alterations in von Hippel-Lindau gene (VHL) do not determine deregulation of hypoxia-inducible factors (HIFs) in clear-cell renal carcinoma (ccRCC). Their effects on tuberous sclerosis proteins (TSC1/2) and heat shock protein 90 (Hsp90) expressions in sporadic ccRCC are unknown.
Svetozar S, Damjanovic, Bojana B, Ilic, Bojana B, Beleslin Cokic, Jadranka A, Antic, Jovana Z, Bankovic, Ivana T, Milicevic, Gordana S, Rodic, Dusan S, Ilic, Vera N, Todorovic, Nela, Puskas, Cane D, Tulic   +10 more
openaire   +2 more sources

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

Cell Reports, 2017
Summary: Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis.
Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning   +7 more
doaj   +1 more source

NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin

Molecular Pain, 2023
Neuropathic pain is a common dose-limiting side effect of oxaliplatin, which hampers the effective treatment of tumors. Here, we found that upregulation of transcription factor NFATc2 decreased the expression of Beclin-1, a critical molecule in autophagy,
Meng Liu, Jing-Wen Mai, De-Xing Luo, Guan-Xi Liu, Ting Xu, Wen-Jun Xin, Su-Yan Lin, Zhen-Yu Li   +7 more
doaj   +1 more source

Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)

Molecular & Cellular Proteomics, 2016
Many biological processes involve the mechanistic/mammalian target of rapamycin complex 1 (mTORC1). Thus, the challenge of deciphering mTORC1-mediated functions during normal and pathological states in the central nervous system is challenging. Because mTORC1 is at the core of translation, we have investigated mTORC1 function in global and regional ...
Farr, Niere, Sanjeev, Namjoshi, Ehwang, Song, Geoffrey A, Dilly, Grant, Schoenhard, Boris V, Zemelman, Yehia, Mechref, Kimberly F, Raab-Graham   +7 more
openaire   +2 more sources

Function of mTOR complex 1 and 2 in skeletal muscle [PDF]

, 2009
Growth of an organ during development and during adaptation in the adult can be controlled by alterations either in the number or the size of cells. The two mechanisms are fundamentally different and require distinct regulation.
Bentzinger, Conrad Florian
core   +1 more source

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]

Open Biology, 2019
Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu, Zhenyu Wang, Jun Yang, Yongkui Wang, Kai Li, Bin Huang, Bo Yan, Ting Wang, Mangmang Li, Zhipeng Zou, Jian Yang, Guozhi Xiao, Zhong-Kai Cui, Anling Liu, Xiaochun Bai   +14 more
doaj   +1 more source

Cardiovascular considerations in tuberous sclerosis [PDF]

, 2017
Tuberous sclerosis complex is a genetic condition with an autosomal dominant pattern of inheritance, with an incidence of approximately 1:10,000, and 1:6,800 in the paediatric population, caused by a mutation of either of two genes: TSC1 on chromosome ...
Mazurek, Bogusław, Lesław Szydłowski, Joanna Kohut, Bogusław Mazurek, Aleksandra Morka, Jacek Pająk, Pająk, Jacek, Kohut, Joanna, Szydłowski, Lesław, Morka, Aleksandra   +9 more
core   +1 more source

Review of Tuberous Sclerosis Complex: A Single Center Experience

, 2021
Aim:The aim of this study is to review the clinical features and treatment of tuberous sclerosis complex patients followed up in our hospital and to compare our findings with the literature.Materials and Methods:The clinical-laboratory findings and ...
Ayşe Tosun, Ali Akyol, Akyol, Ali, Tosun, Ayşe, Yüzbaşı, Beste Kıpçak, Beste Kıpçak Yüzbaşı   +5 more
core   +1 more source

Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis

Scientific Reports, 2017
Tuberous sclerosis (TS) is a multi-organ autosomal dominant disorder that is best characterized by neurodevelopmental deficits and the presence of benign tumors.
Rituraj Pal, Vitaliy V. Bondar, Carolyn J. Adamski, George G. Rodney, Marco Sardiello   +4 more
doaj   +1 more source