Results 21 to 30 of about 28,615 (209)

Tuberous sclerosis complex protein 1 expression is affected by VHL Gene alterations and HIF-1α production in sporadic clear-cell renal cell carcinoma

Experimental and Molecular Pathology, 2016
Alterations in von Hippel-Lindau gene (VHL) do not determine deregulation of hypoxia-inducible factors (HIFs) in clear-cell renal carcinoma (ccRCC). Their effects on tuberous sclerosis proteins (TSC1/2) and heat shock protein 90 (Hsp90) expressions in sporadic ccRCC are unknown.
Svetozar S, Damjanovic, Bojana B, Ilic, Bojana B, Beleslin Cokic, Jadranka A, Antic, Jovana Z, Bankovic, Ivana T, Milicevic, Gordana S, Rodic, Dusan S, Ilic, Vera N, Todorovic, Nela, Puskas, Cane D, Tulic   +10 more
openaire   +2 more sources

Identification of a novel TSC2 c.3610G > A, p.G1204R mutation contribute to aberrant splicing in a patient with classical tuberous sclerosis complex: a case report [PDF]

, 2018
Background: Tuberous sclerosis complex (TSC) is an autosomal dominant disorder characterized by hamartomas in any organ systems. Mutations in the TSC1 or TSC2 gene lead to the dysfunction of hamartin or tuberin proteins, which cause tuberous sclerosis ...
Bottillo, I, Han, Y, Lang, Y, Liu, X, Shao, L., Wang, J, Wang, Q, Zhang, R   +7 more
core   +2 more sources

The mTORC1 Signaling Network Senses Changes in Cellular Purine Nucleotide Levels

Cell Reports, 2017
Summary: Mechanistic (or mammalian) target of rapamycin complex 1 (mTORC1) integrates signals from growth factors and nutrients to control biosynthetic processes, including protein, lipid, and nucleic acid synthesis.
Gerta Hoxhaj, James Hughes-Hallett, Rebecca C. Timson, Erika Ilagan, Min Yuan, John M. Asara, Issam Ben-Sahra, Brendan D. Manning   +7 more
doaj   +1 more source

Osteocyte TSC1 promotes sclerostin secretion to restrain osteogenesis in mice [PDF]

Open Biology, 2019
Osteocytes secrete the glycoprotein sclerostin to inhibit bone formation by osteoblasts, but how sclerostin production is regulated in osteocytes remains unclear.
Wen Liu, Zhenyu Wang, Jun Yang, Yongkui Wang, Kai Li, Bin Huang, Bo Yan, Ting Wang, Mangmang Li, Zhipeng Zou, Jian Yang, Guozhi Xiao, Zhong-Kai Cui, Anling Liu, Xiaochun Bai   +14 more
doaj   +1 more source

Analysis of Proteins That Rapidly Change Upon Mechanistic/Mammalian Target of Rapamycin Complex 1 (mTORC1) Repression Identifies Parkinson Protein 7 (PARK7) as a Novel Protein Aberrantly Expressed in Tuberous Sclerosis Complex (TSC)

Molecular & Cellular Proteomics, 2016
Many biological processes involve the mechanistic/mammalian target of rapamycin complex 1 (mTORC1). Thus, the challenge of deciphering mTORC1-mediated functions during normal and pathological states in the central nervous system is challenging. Because mTORC1 is at the core of translation, we have investigated mTORC1 function in global and regional ...
Farr, Niere, Sanjeev, Namjoshi, Ehwang, Song, Geoffrey A, Dilly, Grant, Schoenhard, Boris V, Zemelman, Yehia, Mechref, Kimberly F, Raab-Graham   +7 more
openaire   +2 more sources

Microglial ASD-related genes are involved in oligodendrocyte differentiation

Scientific Reports, 2021
Autism spectrum disorders (ASD) are associated with mutations of chromodomain-helicase DNA-binding protein 8 (Chd8) and tuberous sclerosis complex 2 (Tsc2).
Yuta Takanezawa, Shogo Tanabe, Daiki Kato, Rie Ozeki, Masayo Komoda, Tatsunori Suzuki, Hiroko Baba, Rieko Muramatsu   +7 more
doaj   +1 more source

Yes-associated protein (YAP) in pancreatic cancer: at the epicenter of a targetable signaling network associated with patient survival. [PDF]

, 2018
Pancreatic ductal adenocarcinoma (PDAC) is generally a fatal disease with no efficacious treatment modalities. Elucidation of signaling mechanisms that will lead to the identification of novel targets for therapy and chemoprevention is urgently needed ...
Eibl, Guido, Rozengurt, Enrique, Sinnett-Smith, James   +2 more
core   +2 more sources

Inhibition of ERK1/2 Restores GSK3β Activity and Protein Synthesis Levels in a Model of Tuberous Sclerosis

Scientific Reports, 2017
Tuberous sclerosis (TS) is a multi-organ autosomal dominant disorder that is best characterized by neurodevelopmental deficits and the presence of benign tumors.
Rituraj Pal, Vitaliy V. Bondar, Carolyn J. Adamski, George G. Rodney, Marco Sardiello   +4 more
doaj   +1 more source

Sestrins Inhibit mTORC1 Kinase Activation through the GATOR Complex

Cell Reports, 2014
The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a sensor of different environmental conditions and regulator of cell growth, metabolism, and autophagy.
Anita Parmigiani, Aida Nourbakhsh, Boxiao Ding, Wei Wang, Young Chul Kim, Konstantin Akopiants, Kun-Liang Guan, Michael Karin, Andrei V. Budanov   +8 more
doaj   +1 more source

mTOR pathway – a potential therapeutic target in stroke

Therapeutic Advances in Neurological Disorders, 2023
Stroke is ranked as the second leading cause of death worldwide and a major cause of long-term disability. A potential therapeutic target that could offer favorable outcomes in stroke is the mammalian target of rapamycin (mTOR) pathway.
Konstantinos Melanis, Maria-Ioanna Stefanou, Konstantinos M. Themistoklis, Themistoklis Papasilekas   +3 more
doaj   +1 more source