Results 41 to 50 of about 28,615 (209)
Neurobiology of Disease, 2009 The control of translation is disturbed in Alzheimer's disease (AD). This study analysed the crosslink between the up regulation of double-stranded RNA-dependent-protein kinase (PKR) and the down regulation of mammalian target of rapamycin (mTOR ...
Milena Morel +6 more
doaj +1 more source
mTOR Hyperactivation by Ablation of Tuberous Sclerosis Complex 2 in the Mouse Heart Induces Cardiac Dysfunction with the Increased Number of Small Mitochondria Mediated through the Down-Regulation of Autophagy. [PDF]
PLoS ONE, 2016 Mammalian target of rapamycin complex 1 (mTORC1) is a key regulator of cell growth, proliferation and metabolism. mTORC1 regulates protein synthesis positively and autophagy negatively. Autophagy is a major system to manage bulk degradation and recycling
Manabu Taneike +11 more
doaj +1 more source
Dynamic Akt/mTOR Signaling in Children with Autism Spectrum Disorder. [PDF]
, 2017 Autism spectrum disorder (ASD) is a behaviorally defined disorder affecting 1 in 68 children. Currently, there is no known cause for the majority of ASD cases nor are there physiological diagnostic tools or biomarkers to aid behavioral diagnosis.
Ashwood, Paul +3 more
core +1 more source
Vascular Growth in the Fetal Lung [PDF]
, 2011 The structure of the lung is truly remarkable. It is primarily composed of three branched tubular networks (the airway, pulmonary artery and vein, bronchial artery and vein) which supply blood and air to the site of gas exchange and which maintain ...
Land, Stephen
core +4 more sources
Regulation of colonic epithelial cell homeostasis by mTORC1
Scientific Reports, 2020 Cell signaling important for homeostatic regulation of colonic epithelial cells (CECs) remains poorly understood. Mammalian target of rapamycin complex 1 (mTORC1), a protein complex that contains the serine-threonine kinase mTOR, mediates signaling that ...
Takenori Kotani +8 more
doaj +1 more source
Therapeutic trial of metformin and bortezomib in a mouse model of tuberous sclerosis complex (TSC). [PDF]
PLoS ONE, 2012 Tuberous sclerosis complex (TSC) is a human genetic disorder in which loss of either TSC1 or TSC2 leads to development of hamartoma lesions, which can progress and be life-threatening or fatal.
Neil Auricchio +4 more
doaj +1 more source
Clinical and Molecular Assessment in a Female with Fragile X Syndrome and Tuberous Sclerosis. [PDF]
, 2016 Fragile X syndrome (FXS) and tuberous sclerosis (TSC) are genetic disorders that result in intellectual disability and an increased prevalence of autism spectrum disorders (ASD). While the clinical presentation of each disorder is distinct, the molecular
Bagni, C. +6 more
core +1 more source
FMRP S499 is phosphorylated independent of mTORC1-S6K1 activity.
PLoS ONE, 2014 Hyperactive mammalian target of rapamycin (mTOR) is associated with cognitive deficits in several neurological disorders including tuberous sclerosis complex (TSC). The phosphorylation of the mRNA-binding protein FMRP reportedly depends on mTOR complex 1
Christopher M Bartley +2 more
doaj +1 more source
Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis [PDF]
, 2013 The protein products of the tuberous sclerosis complex (TSC) genes, TSC1 and TSC2, form a complex, which inhibits the small G-protein, Ras homolog enriched in brain (Rheb).
Henske, Elizabeth Petri +1 more
core +1 more source
Advanced Science, EarlyView.Human‐relevant methods are essential for modern chemical safety assessment. This study helps define the capabilities and boundaries of an in vitro testing battery for developmental neurotoxicity by exploring its biological applicability domain. By linking neurodevelopmental disease‐related pathways to key neurodevelopmental processes, the work enhances
Eliska Kuchovska +14 more
wiley +1 more source