Results 1 to 10 of about 47,262 (255)

Mechanism of Activation of Mechanistic Target of Rapamycin Complex 1 by Methionine [PDF]

Frontiers in Cell and Developmental Biology, 2020
Nutrients are closely involved in the regulation of lifespan and metabolic health. Cellular activities, such as the regulation of metabolism, growth, and aging, are mediated by a network of nutrients and nutrient-sensing pathways.
Munehiro Kitada, Munehiro Kitada, Jing Xu, Yoshio Ogura, Itaru Monno, Daisuke Koya, Daisuke Koya   +6 more
doaj   +7 more sources

Mechanistic Target of Rapamycin Complex 1 Signaling Modulates Vascular Endothelial Function Through Reactive Oxygen Species [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background The mechanistic target of rapamycin complex 1 (mTORC1) is an important intracellular energy sensor that regulates gene expression and protein synthesis through its downstream signaling components, the S6‐kinase and the ribosomal S6 protein ...
John J. Reho, Deng‐Fu Guo, Kamal Rahmouni   +2 more
doaj   +6 more sources

Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells [PDF]

Biomolecules, 2021
Insulin-like growth factor-1 (IGF-1) bioavailability in pregnancy is governed by IGF binding protein (IGFBP-1) and its phosphorylation, which enhances the affinity of IGFBP-1 for the growth factor.
Pinki Nandi, Chloe E. Jang, Kyle Biggar, Chidambra D. Halari, Thomas Jansson, Madhulika B. Gupta   +5 more
doaj   +8 more sources

Takeda G Protein-Coupled Receptor 5-Mechanistic Target of Rapamycin Complex 1 Signaling Contributes to the Increment of Glucagon-Like Peptide-1 Production after Roux-en-Y Gastric Bypass [PDF]

EBioMedicine, 2018
Background: The mechanism by which Roux-en-Y Gastric Bypass (RYGB) increases the secretion of glucagon-like peptide-1 (GLP-1) remains incompletely defined.
Hening Zhai, Zhi Li, Miao Peng, Zhaoqi Huang, Tingfeng Qin, Linxi Chen, Hanbing Li, Heng Zhang, Weizhen Zhang, Geyang Xu   +9 more
doaj   +5 more sources

Enhanced activation of mechanistic target of rapamycin complex 1 signaling in eruptive xanthomas [PDF]

JAAD International, 2023
Yan Huang, BS, Baiping Cui, PhD, Yun Bai, PhD, Juan Wang, PhD, Hanyu Dou, BS, Yanfei Jin, MS, Qian Du, MD, Yongxian Lai, MD, Yeqiang Liu, MD, PhD, Xiaolei Ding, PhD   +9 more
doaj   +4 more sources

Transcriptional and Epigenetic Regulation by the Mechanistic Target of Rapamycin Complex 1 Pathway. [PDF]

J Mol Biol, 2018
Nutrient availability impacts health such that nutrient excess states can dysregulate epigenetic and transcriptional pathways to cause many diseases. Increasing evidence implicates aberrant regulation of nutrient signaling cascades as one means of communicating nutrient information to the epigenetic and transcriptional regulatory machinery.
Laribee RN.
europepmc   +5 more sources

Dynamin-dependent amino acid endocytosis activates mechanistic target of rapamycin complex 1 (mTORC1). [PDF]

J Biol Chem, 2017
The mechanistic target of rapamycin complex 1 (mTORC1) is a master regulator of protein synthesis and potential target for modifying cellular metabolism in various conditions, including cancer and aging. mTORC1 activity is tightly regulated by the availability of extracellular amino acids, and previous studies have revealed that amino acids in the ...
Shibutani S, Okazaki H, Iwata H.
europepmc   +5 more sources

Mechanistic target of rapamycin complex 1 orchestrates the interplay between hepatocytes and Kupffer cells to determine the outcome of immune-mediated hepatitis [PDF]

Cell Death and Disease, 2022
The cell-cell interaction between hepatocytes and Kupffer cells (KCs) is crucial for maintaining liver homeostasis, and the loss of KCs and hepatocytes is known to represent a common pathogenic phenomenon in autoimmune hepatitis.
Xiaoli Sun, Yajie Ni, Qingmiao Lu, Yan Liang, Mengru Gu, Xian Xue, Chunsun Dai   +6 more
doaj   +4 more sources

RhoA modulates signaling through the mechanistic target of rapamycin complex 1 (mTORC1) in mammalian cells. [PDF]

Cell Signal, 2014
The mechanistic target of rapamycin (mTOR) in complex 1 (mTORC1) pathway integrates signals generated by hormones and nutrients to control cell growth and metabolism. The activation state of mTORC1 is regulated by a variety of GTPases including Rheb and Rags.
Gordon BS, Kazi AA, Coleman CS, Dennis MD, Chau V, Jefferson LS, Kimball SR.   +6 more
europepmc   +5 more sources

Mechanistic Target of Rapamycin Complex 1: From a Nutrient Sensor to a Key Regulator of Metabolism and Health. [PDF]

Adv Nutr, 2022
Mechanistic target of rapamycin complex 1 (mTORC1) is a multi-protein complex widely found in eukaryotes. It serves as a central signaling node to coordinate cell growth and metabolism by sensing diverse extracellular and intracellular inputs, including amino acid-, growth factor-, glucose-, and nucleotide-related signals.
Wang G, Chen L, Qin S, Zhang T, Yao J, Yi Y, Deng L.   +6 more
europepmc   +3 more sources