Arquivos de Neuro-Psiquiatria, 2023 Background Tuberous sclerosis (TS) is a multisystem genetic disease in which epilepsy is a frequent manifestation and is often difficult to control. Everolimus is a drug with proven efficacy in the treatment of other conditions related to TS, and some ...
Catarina Ester Gomes Menezes +7 more
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The Journal of Qazvin University of Medical Sciences, 2021 Mammalian Target Of Rapamycine (mTOR) is a conserved serine/threonine kinase in the PI3K/Akt/ mTOR signaling pathway. This pathway is regulated by changes in cells such as change in energy level, growth factors, and stressful conditions as well as ...
Forough Alemi Serej +6 more
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Advancements in the diagnosis and treatment of renal epithelioid angiomyolipoma: A narrative review
Kaohsiung Journal of Medical Sciences, 2022 Renal epithelioid angiomyolipoma (EAML) is a unique subtype of angiomyolipoma that contains a variety of cytoplasmic‐rich, eosinophilic cytoplasm epithelioid cells in addition to mature adipocytes, hyaline thick‐walled vessels, and smooth muscle‐like ...
Jian‐Wei Yang, Cheng Liang, Li Yang
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Alternative Polyadenylation in Human Diseases [PDF]
Endocrinology and Metabolism, 2017 Varying length of messenger RNA (mRNA) 3′-untranslated region is generated by alternating the usage of polyadenylation sites during pre-mRNA processing.
Jae-Woong Chang +2 more
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Molecules, 2023 Background: Obesity is a complex multifactorial disease characterized by excessive adiposity, and is linked to an increased risk of nonalcoholic fatty liver disease (NAFLD).
Ghaleb Oriquat +5 more
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BMC Genomics, 2023 Background Dormancy is widespread in both multicellular and unicellular organisms. Among diatoms, unicellular microalgae at the base of all aquatic food webs, several species produce dormant cells (spores or resting cells) that can withstand long periods
Angela Pelusi +6 more
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Association of Genetic Variations in The PIK3-AKT-mTOR Pathway with Endometriosis Susceptibility: A Preliminary Case-Control Study [PDF]
International Journal of Fertility and SterilityBackground: Endometriosis is a complex, heterogeneous disease with several genetic and non-genetic pathogenic factors. The phosphatidylinositol 3-kinase/protein kinase B/mammalian target of rapamycin (PI3K/AKT/mTOR) pathway may influence both ...
Rahele Ghasemian Moghadam +5 more
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Global analysis of serine/threonine and tyrosine protein phosphatase catalytic subunit genes in Neurospora crassa reveals interplay between phosphatases and the p38 mitogen-activated protein kinase. [PDF]
, 2013 Protein phosphatases are integral components of the cellular signaling machinery in eukaryotes, regulating diverse aspects of growth and development. The genome of the filamentous fungus and model organism Neurospora crassa encodes catalytic subunits for
Borkovich, Katherine A +3 more
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Mechanistic target of rapamycin (mTOR) signaling genes in decapod crustaceans: cloning and tissue expression of mTOR, Akt, Rheb, and S6 kinase in the green crab, Carcinus maenas, and blackback land crab, Gecarcinus lateralis [PDF]
, 2014 Mechanistic target of rapamycin (mTOR) controls global translation of mRNA into protein by phosphorylating p70 S6 kinase (S6K) and eIF4E-binding protein-1. Akt and Rheb, a GTP-binding protein, regulate mTOR protein kinase activity. Molting in crustaceans
Abuhagr, Ali M. +3 more
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Pretreatment of artesunate promoted hepatocyte proliferation by activating the PI3K/Akt/mTOR signaling pathway in mice [PDF]
Acta Cirúrgica BrasileiraPurpose: Artesunate (ART) has been implicated in regulating the many processes of liver injury, but its roles in liver regeneration still need to be illustrated.
Changyou Lu +5 more
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