Genome-wide Identification and expression analysis of TOR signaling pathway components in apple in response to low nitrogen. [PDF]
Plant GenomeAbstract Target of rapamycin (TOR) is an evolutionarily conserved serine/threonine kinase that plays a central role in regulating biological growth, development, and stress responses in eukaryotes. However, the TOR signaling pathway has not been thoroughly studied in apple (Malus domestica).
Liu D +7 more
europepmc +2 more sources
Fully Tunable Phosphorylation of RPS6A Ensures the Successful Development of Arabidopsis Seedlings. [PDF]
Plant Cell EnvironABSTRACT Light enhances protein translation, enabling young seedlings to rapidly and timely acquire photosynthetic capacities. Sequential phosphorylation of ribosomal protein S6 (RPS6) was implicated in the light‐enhanced translation; however, the exact phosphorylation sites and the biological relevance of RPS6 multi‐phosphorylation in seedling ...
Cho Y, Chen GH, Wu SH.
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Exploring downstream pathways of aberrantly activated kinases for targeted leukemia therapy [PDF]
, 2008 Genetic alterations resulting in uncontrolled protein tyrosine kinases (PTKs) activity are frequently found in leukemia and in human solid cancers. Although the development of small molecule kinase inhibitors has revolutionized therapy for PTKinduced ...
Gasser, Christelle
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Characterization of TOR complex 2 (TORC2) in "Saccharomyces cerevisiae" [PDF]
, 2004 The TOR proteins play a central role in the control of cell growth. TOR proteins are the founding members of the phosphatidylinositol-related kinase (PIKK) family of protein kinases. In S. cerevisiae there are two TOR proteins, TOR1 and TOR2.
Wullschleger, Stephan
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Mechanism of activation of NDR protein kinase by the HMOB1 protein [PDF]
, 2005 Serine/threonine kinases of the nuclear Dbf2-related (NDR) family are highly conserved throughout the eukaryotic world. Members of this kinase family are implicated in various aspects of the regulation of cell division and cell morphology. It has been
Bichsel, Samuel J.
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New insights into the "in vivo" and "in vitro" functions of mammalian TOR complex 2 [PDF]
, 2010 Target of rapamycin (TOR) is the main controller of cell growth and metabolism in response to nutrients, growth factors and the cellular energy status. TOR is a serine/threonine kinase conserved from yeast to mammals and is found in two functionally and
Cybulski, Nadine
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Functional analysis of TOR complex 2 and its control of sphingolipid biosynthesis in "Saccharomyces cerevisiae" [PDF]
, 2006 sphingoid base, one of the intermediate of sphingolipids metabolites, plays a key role as a signaling molecule which activate PKH kinases and its substrates YPKs and PKC1 (Casamayor, Torrance et al. 1999; Friant, Lombardi et al.
Shioda, Ryo
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Deep evolutionary conservation of an intramolecular protein kinase activation mechanism [PDF]
, 2012 DYRK-family kinases employ an intramolecular mechanism to autophosphorylate a critical tyrosine residue in the activation loop. Once phosphorylated, DYRKs lose tyrosine kinase activity and function as serine/threonine kinases.
Cleghon Vaughn +31 more
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Upstream regulation of yeast TOR complexes [PDF]
, 2015 Nitrogen is an essential component of living organism. Protein synthesis and biosynthesis of nitrogen containing molecules essential for growth, such as amino acids and NAD, strictly depend on the availability of the nitrogen source. Limiting amount of
Stracka, Daniele
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Expanding the Hippo pathway : hMOB3 modulates apoptotic MST1 signaling and supports tumor growth in glioblastoma [PDF]
, 2014 Protein kinases are critical players of signal transduction pathways involved in development, physiological and pathological processes. Deregulation of protein kinase signaling is found to be causal or related to varieties of human diseases, such as ...
Tang, Fengyuan
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