Results 31 to 40 of about 20,110 (149)
Complex Regulation of RETINOBLASTOMA‐RELATED's Interactions With E2Fs via Phosphorylation
Plant, Cell &Environment, EarlyView.ABSTRACT Arabidopsis RETINOBLASTOMA‐RELATED (RBR) regulates cell proliferation by interacting with E2F transcription factors and DIMERISATION PARTNER, RB‐LIKE, E2F AND MULTI‐VULVAL CLASS B COMPLEX (DREAM) components. Although CDK‐CYCD phosphorylation is believed to affect RBR's E2F‐binding capacity, the precise phosphorylation events inhibiting RBR's ...
Aladár Pettkó‐Szandtner +10 more
wiley +1 more source
Plant, Cell &Environment, EarlyView.ABSTRACT In this study, we analyzed a unique Nicotiana tabacum BY‐2 line that was gradually adapted to and subsequently maintained in 190 mM NaCl for over 15 years. Years of continuous high salinity shaped a stable “new homeostasis” in BY‐2 suspension cells. Salt‐adapted cells were smaller and formed tighter clusters. Metabolomics revealed constitutive
Anita Rzadkiewicz +8 more
wiley +1 more source
Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Food Biomacromolecules, Volume 3, Issue 2, Page 237-251, June 2026.Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley +1 more source
, 2011 The TOR (target of rapamycin) serine/threonine kinases are fascinating in that they influence many different aspects of eukaryote physiology including processes often dysregulated in disease. Beginning with the initial characterization of rapamycin as an
Robbie Loewith, Loewith, Robbie Joséph
core +1 more source
Regulation of protein kinase B (PKB/Akt) by DNA-dependent protein kinase (DNA-PK) under physiological conditions [PDF]
, 2010 The serine/threonine protein kinase B (PKB/Akt) is a downstream effector of phosphatidylinositol 3-kinase (PI3K) and a major regulator of a variety of cellular processes, including metabolism, transcription, survival, proliferation, and growth.
Sürücü, Banu
core +1 more source
Phosphorylation of the TOR ATP binding domain by AGC kinase constitutes a novel mode of TOR inhibition [PDF]
, 2013 TOR (target of rapamycin) signaling coordinates cell growth, metabolism, and cell division through tight control of signaling via two complexes, TORC1 and TORC2.
Lenka Hálová +9 more
core +1 more source
Zdravniški Vestnik, 2014 Tuberous sclerosis complex is a genetic disorder with a characteristic development of a benign tumorous growth in various tissues. Clinical picture is very heterogeneous, resulting in difficult diagnosis and unrecognized patients.
Alexander Jerman, Jelka Lindič
doaj
Functional analysis of the "Saccharomyces cerevisiae" Npr1 protein kinase [PDF]
, 2007 The uptake and processing of nutrients is highly regulated. Cells adapt to changes of the availability of nutrients to provide a complete set of transporters and metabolizing enzymes for optimal use of the available nutrients.
Gander, Stefan
core +1 more source
CLE peptide signaling during plant development
, 2009 Peptide signaling in plants is a rapid developing area of research which focuses on so called peptide hormones. These signaling molecules are utilized for inter-cellular communication in different developmental processes, beside the usage of the more ...
Fiers, M.A. +3 more
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Status Epilepticus Alters the Function of Brain‐Derived Extracellular Vesicles
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Samantha L. Reed +6 more
wiley +1 more source