Results 31 to 40 of about 332,444 (133)
On-Bead Fluorescence Assay for Serine/Threonine Kinases
, 2016 A novel fluorescence-based assay for serine/threonine kinases is described. Base-mediated β-elimination of the phosphate moiety and the Michael addition of a thiol-containing fluorescent molecule allows convenient and efficient detection of the enzyme ...
Tsunehiko Higuchi (1975732) +2 more
core +1 more source
ErbB2 signaling in breast cancer : the role of ErbB, Akt and ShcA phosphorylation [PDF]
, 2004 Breast cancer is the most common malignancy in women and is estimated to account for more than 200,000 new cancer cases in the United States in the year 2002. It now represents the second leading cause of death (40,000) from cancer in women.
Cicenas, Jonas
core +1 more source
Microtubule-Associated Serine/Threonine (MAST) Kinases in Development and Disease
, 2023 Microtubule-Associated Serine/Threonine (MAST) kinases represent an evolutionary conserved branch of the AGC protein kinase superfamily in the kinome. Since the discovery of the founding member, MAST2, in 1993, three additional family members have been ...
Sabine Pautz +4 more
core +1 more source
The role of serine/threonine kinases in T-cell activation
, 2006 Signalling through serine/threonine kinases is a key mechanism that regulates immune cell development, activation and effector functions. An emerging theme is that serine kinases do not act in isolation, but function in a complex overlapping network ...
Sharon A Matthews +3 more
core +1 more source
Bioinformatic search of plant microtubule-and cell cycle related serine-threonine protein kinases [PDF]
, 2010 A bioinformatic search was carried for plant homologues of human serine-threonine protein kinases involved in regulation of cell division and microtubule protein phosphorylation (SLK, PAK6, PAK7, MARK1, MAST2, TTBK1, TTBK2, AURKA, PLK1, PLK4 and PASK). A
Nadezhdina Elena S +13 more
core +1 more source
Status Epilepticus Alters the Function of Brain‐Derived Extracellular Vesicles
Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Samantha L. Reed +6 more
wiley +1 more source
Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles
MedComm, Volume 7, Issue 6, June 2026.This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang +12 more
wiley +1 more source
Serine-threonine kinases in TCR signaling
, 2014 T lymphocyte proliferation and differentiation are controlled by signaling pathways initiated by the T cell antigen receptor. Here we explore how key serine-threonine kinases and their substrates mediate T cell signaling and coordinate T cell metabolism ...
Doreen A Cantrell +3 more
core +1 more source
PeSTK db: A comprehensive data repository of Probiotic Serine, Threonine kinases.
, 2022 Datasets of Serine threonine kinases of Bifidobacteria spp. Probiotics are Generally Recognized As Safe (GRAS), and are beneficial microbes. It implies that they hold the power to feel the presence of pathogens in the surrounding subsequently they ...
Suresh PSN (10860997) +2 more
core +1 more source
Effect of serine/threonine kinases on autophagy mechanism
, 2016 Autophagy is a degradation pathway, activating under stress conditions. It digests macromolecules, such as abnormal proteins and long-lived organelles by engulfing them and by subsequent delivery of the cargo to lysosomes. The members of the phospholipid-
Yedier, Özlem +4 more
core +1 more source