An ABC transporter containing a forkhead-associated domain interacts with a serine-threonine protein kinase and is required for growth of Mycobacterium tuberculosis in mice [PDF]
Forkhead-associated (FHA) domains are modular phosphopeptide recognition motifs with a striking preference for phosphothreonine-containing epitopes. FHA domains have been best characterized in eukaryotic signaling pathways but have been identified in six
Curry, JM +8 more
core
Viral serine/threonine protein kinases
Phosphorylation represents one the most abundant and important posttranslational modifications of proteins, including viral proteins. Virus-encoded serine/threonine protein kinases appear to be a feature that is unique to large DNA viruses.
Thary Jacob +5 more
core +1 more source
Mammalian NDR kinases : tumor suppressors with essential functions in embryonic development [PDF]
NDR kinases are highly conserved from yeast to man. Loss-of-function models of Ndr homologs in yeast and fly demonstrate essential functions of the respective kinases.
Schmitz-Rohmer, Debora
core +1 more source
Characterisation of ATP-Dependent Mur Ligases Involved in the Biogenesis of Cell Wall Peptidoglycan in Mycobacterium tuberculosis [PDF]
ATP-dependent Mur ligases (Mur synthetases) play essential roles in the biosynthesis of cell wall peptidoglycan (PG) as they catalyze the ligation of key amino acid residues to the stem peptide at the expense of ATP hydrolysis, thus representing ...
Nicholas H Keep +29 more
core +1 more source
Deep evolutionary conservation of an intramolecular protein kinase activation mechanism [PDF]
DYRK-family kinases employ an intramolecular mechanism to autophosphorylate a critical tyrosine residue in the activation loop. Once phosphorylated, DYRKs lose tyrosine kinase activity and function as serine/threonine kinases.
Cleghon Vaughn +31 more
core +1 more source
Mechanism of regulation of Raf-1 by Ca2+/Calmodulin-dependent kinase II [PDF]
The calcium-calmodulin dependent kinase II (CaMKII) is an ubiquitous serine/threonine protein kinase involved in multiple signalings and biological functions.
Salzano, Marcella
core +1 more source
Analysis of cyanobacteria serine/threonine protein kinases. [PDF]
Analysis of Cyanobacteria Serine/Threonine Protein Kinases The main purpose of this research was phylogenetic analyses of serine/threonine protein kinases in cyanobacterias and better cyanobacterias taxonomy.
Žalytė, Rimantė,
core
Cross-phosphorylation of bacterial serine/threonine and tyrosine protein kinases on key regulatory residues [PDF]
Bacteria possess protein serine/threonine and tyrosine kinases which resemble eukaryal kinases in their capacity to phosphorylate multiple substrates. We hypothesized that the analogy might extend further, and bacterial kinases may also undergo mutual ...
Ivan eMijakovic +37 more
core +1 more source
Novel roles for the MAPK-interacting serine threonine kinases (Mnks)
The mitogen activated protein kinase (MAPK)-interacting serine threonine kinases (Mnks) are components of the MEK/ERK and p38MAPK signalling pathways.
Stead, Rebecca
core +1 more source
Dietary and biomarker‐guided strategies as supportive measures in the fragile X syndrome
Abstract The fragile X syndrome (FXS) is an inherited neurodevelopmental disorder that primarily affects males, often resulting in an IQ below 55, while about two‐thirds of females also experience intellectual disability. Physical features may include an elongated face, prominent ears, finger joint laxity, and enlarged testes in males.
Jailan E. El Halawani, Reem R. AlOlaby
wiley +1 more source

