Results 41 to 50 of about 33,208 (149)
Aging Cell, Volume 25, Issue 5, May 2026.We developed a LASSO‐based approach to uncover a three‐layered “fan‐in fan‐out” network architecture for complex traits like yeast aging, showing that peripheral genes influence lifespan indirectly through master regulators, which converge on core functional modules (e.g., stress response, autophagy).
Meng Ma +12 more
wiley +1 more source
Zdravniški Vestnik, 2014 Tuberous sclerosis complex is a genetic disorder with a characteristic development of a benign tumorous growth in various tissues. Clinical picture is very heterogeneous, resulting in difficult diagnosis and unrecognized patients.
Alexander Jerman, Jelka Lindič
doaj
New Phytologist, Volume 250, Issue 2, Page 1023-1040, April 2026.Summary In plants, hypoxia sensing is controlled by the stabilization of group VII ethylene response factors (ERF‐VIIs), which are post‐translationally activated by the mitogen‐activated protein kinases (MAPKs) MPK3 and MPK6. However, how plants fine‐tune the MPK3/MPK6‐mediated phosphorylation of ERF‐VIIs to maintain cellular homeostasis remains ...
De‐Mian Zhou +9 more
wiley +1 more source
How to rewire the host cell: A home improvement guide for intracellular bacteria. [PDF]
, 2017 Intracellular bacterial pathogens have developed versatile strategies to generate niches inside the eukaryotic cells that allow them to survive and proliferate.
Cornejo, Elias +2 more
core +2 more sources
Journal of Intelligent Medicine, Volume 3, Issue 1, Page 47-68, March 2026.Abstract The isoproterenol‐induced myocardial infarction model is a well‐established experimental approach for studying cardiac injury and testing potential protective treatments. By overstimulating beta‐adrenergic receptors, this model closely reproduces key features of human heart attacks, including oxidative damage, calcium imbalance, inflammatory ...
Bushra Imran +5 more
wiley +1 more source
Journal of Sustainable Agriculture and Environment, Volume 5, Issue 1, March 2026.ABSTRACT The foliar application of amino acids offers a promising strategy to mitigate multiple abiotic stresses—drought, salinity, heat and heavy metals—by enhancing plant physiological, biochemical and molecular responses. This review synthesises recent advances in understanding how external amino acids function as bio‐stimulants, focusing on ...
Xiaoyu Ma +4 more
wiley +1 more source
Differential alphav integrin-mediated Ras-ERK signaling during two pathways of angiogenesis. [PDF]
, 2003 Antagonists of alphavbeta3 and alphavbeta5 disrupt angiogenesis in response to bFGF and VEGF, respectively. Here, we show that these alphav integrins differentially contribute to sustained Ras-extracellular signal-related kinase (Ras-ERK) signaling in ...
Cheresh, David A +4 more
core +1 more source
Valosin-containing protein regulates the proteasome-mediated degradation of DNA-PKcs in glioma cells. [PDF]
, 2013 DNA-dependent protein kinase (DNA-PK) has an important role in the repair of DNA damage and regulates the radiation sensitivity of glioblastoma cells. The VCP (valosine-containing protein), a chaperone protein that regulates ubiquitin-dependent protein ...
Cao, L +9 more
core +1 more source
Alzheimer's &Dementia, Volume 22, Issue 2, February 2026.Abstract Alzheimer's disease (AD) is a progressive, age‐related, neurodegenerative disorder marked by cognitive decline, memory loss, and accumulation of amyloid beta (Aβ) plaques and tau tangles. A key feature of AD is impaired protein homeostasis, often driven by autophagy dysfunction.
Ajish Ariyath +9 more
wiley +1 more source
TGFβ activates c-Jun and Erk1 via αβ integrin [PDF]
, 2003 Transforming growth factor β (TGFβ) plays an important role in animal development and many cellular processes. A variety of cellular functions that are required for tumor metastasis are controlled by integrins, a family of cell adhesion receptors ...
Schmidt Christian, Luettich Karsta
core +2 more sources