Results 41 to 50 of about 20,110 (149)
"Drosophila" genetics as a tool in the search for novel components of the S6 kinase signaling pathway [PDF]
, 2009 Signaling events that converge on the activation of the TOR/S6K pathway have been shown to be critically related to growth. Recent investigations on the molecular network controlling growth have revealed that Drosophila melanogaster constitutes an ...
Bennion, Janis Michelle
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Targeting Mitochondria in Aging‐Related Diseases: Therapeutic Potential and Obstacles
MedComm, Volume 7, Issue 6, June 2026.This article systematically summarized the specific mechanism of aging‐related diseases caused by mitochondrial dysfunction, and summarized the broad‐spectrum treatment methods and disease targeted treatment strategies for mitochondria. At the same time, it also pointed out the dilemma faced by mitochondrial targeted treatment.
Zijie Xiang +12 more
wiley +1 more source
, 1996 TheRaffamily of serine/threonine kinases are essential components in many receptor tyrosine kinase-mediated signal transduction pathways. Here, we analyze the function of D-raf in the Torso (Tor) pathway required to specify cellular fates at the ...
Fabian, John R. +4 more
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mTORC2 controls neuron size and Purkinje cell morphology independent of mTORC1 [PDF]
, 2012 Prenatal brain development is mainly accomplished by extensive proliferation of neuronal precursor cells whereas postnatal brain growth in mammals is mainly mediated by the growth of those post-mitotic nerve cells.
Thomanetz, Venus
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Food and Energy Security, Volume 15, Issue 3, May/June 2026.ABSTRACT The maize pericarp serves not only as a physical protective barrier of the seed but also as a critical functional interface involved in environmental response and physiological regulation. Systematic analysis of the metabolic basis of nutritional components and related metabolites in the maize pericarp is of great importance for quality ...
Yanru Wang +10 more
wiley +1 more source
Regulation of the mammalian target of rapamycin complex 2 (mTORC2) [PDF]
, 2006 The growth controlling mammalian Target of Rapamycin (mTOR) is a conserved Ser/Thr kinase found in two structurally and functionally distinct complexes, mTORC1 and mTORC2.
Molle, Klaus-Dieter
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Aging Cell, Volume 25, Issue 5, May 2026.We developed a LASSO‐based approach to uncover a three‐layered “fan‐in fan‐out” network architecture for complex traits like yeast aging, showing that peripheral genes influence lifespan indirectly through master regulators, which converge on core functional modules (e.g., stress response, autophagy).
Meng Ma +12 more
wiley +1 more source
Análisis de la regulación mediada por CK2 de la polimerización de actina inducida por Myo5 durante la internalización endocítica en “S. Cerevisiae” [PDF]
, 2012 [eng] S. cerevisiae (budding yeast) is particularly powerful to study the relation between the molecular mechanisms of actin regulation and its biological significance due to its powerful molecular and genetic methods, well-established biochemical ...
Fernández Golbano, Isabel M.
core
Dissecting the roles of mTORC1 and mTORC2 in the mouse heart [PDF]
, 2013 Mammalian target of rapamycin (mTOR) is an evolutionary conserved serine/threonine kinase that regulates cell growth and metabolism. mTOR occurs in cells in two complexes, termed mTORC1 and mTORC2.
Shende, Pankaj
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The function of the protein phosphatase Glc7p in transcription termination, RNA processing and transcriptional regulation of ribosomal protein genes [PDF]
, 2007 Gene transcription in general can be subdivided into three main phases: transcription initiation, elongation and termination. The enzyme that accomplishes transcription of protein coding genes, snRNAs and snoRNAs is RNA polymerase II (RNAP II).
Röck, Salome
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