Very Stable High-Molecular-Mass Multiprotein Complexes in Different Organs of the Sea Cucumber Paracaudina chilensis [PDF]
MoleculesWe report the first identification of several large (1.4–2.2 MDa), highly stable protein–peptide complexes in various organs and tissues (body wall, gonads, respiratory trees, gut, and coelomic fluid) of the sea cucumber Paracaudina chilensis.
Svetlana E. Soboleva +5 more
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Structure-Based Characterization of Multiprotein Complexes
Structure, 2014 Multiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes.
Francisco Melo +2 more
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MultiBac: expanding the research toolbox for multiprotein complexes [PDF]
Trends in Biochemical Sciences, 2012 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Tsuyoshi Imasaki +2 more
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Multiprotein Complexes of Plant Glycosyltransferases Involved in Their Function and Trafficking [PDF]
PlantsPlant cells utilize protein oligomerization for their functions in numerous important cellular processes. Protein-protein interactions are necessary to stabilize, optimize, and activate enzymes, as well as localize proteins to specific organelles and ...
Ning Zhang +2 more
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Two binding sites are better than one [PDF]
eLifeThe reasons why two multiprotein complexes – VPS34 complex I and VPS34 complex II – are activated by different Rab proteins are becoming clearer.
Mackenzie K Scott, John E Burke
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Resolving endogenous protein organization in cells with nanometer resolution [PDF]
Nature CommunicationsLatest refinements in super-resolution microscopy achieved spatial resolutions in the one nanometer range. However, improvement of localization precision advanced faster than labeling methods impeding the translation of such high resolutions to cells ...
Janna Eilts +10 more
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A Scalable Genome-Editing-Based Approach for Mapping Multiprotein Complexes in Human Cells
Cell Reports, 2015 Conventional affinity purification followed by mass spectrometry (AP-MS) analysis is a broadly applicable method used to decipher molecular interaction networks and infer protein function.
Mathieu Dalvai +7 more
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Multicolour fluorescence-detection size-exclusion chromatography for structural genomics of membrane multiprotein complexes. [PDF]
PLoS ONE, 2013 Many interesting and important membrane proteins are hetero-oligomeric. However, besides naturally abundant examples, the structures of relatively few such complexes are known.
David Parcej +4 more
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MAP kinases associate with high molecular weight multiprotein complexes [PDF]
Journal of Experimental Botany, 2018 Johannes W Stratmann, Sarah Hind
exaly +2 more sources
Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer
Life, 2022 The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and ...
Fan Yang +4 more
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