A proteomic approach based on peptide affinity chromatography, 2-dimensional electrophoresis and mass spectrometry to identify multiprotein complexes interacting with membrane-bound receptors [PDF]
Biological Procedures Online, 2002 There is accumulating evidence that membrane-bound receptors interact with many intracellular proteins. Multiprotein complexes associated with ionotropic receptors have been extensively characterized, but the identification of proteins interacting with G
Bécamel Carine +6 more
doaj +2 more sources
Ion channels as part of macromolecular multiprotein complexes : Clinical significance. [PDF]
Herzschrittmacherther Elektrophysiol, 2018 Ion channels and Ca2+-handling proteins involved in the regulation of cardiac electrophysiology and contractility are organized in macromolecular multiprotein complexes.
Heijman J, Dobrev D.
europepmc +2 more sources
Exploring the Complexity of Protein-Level Dosage Compensation that Fine-Tunes Stoichiometry of Multiprotein Complexes. [PDF]
PLoS Genet, 2020 Proper control of gene expression levels upon various perturbations is a fundamental aspect of cellular robustness. Protein-level dosage compensation is one mechanism buffering perturbations to stoichiometry of multiprotein complexes through accelerated ...
Ishikawa K, Ishihara A, Moriya H.
europepmc +3 more sources
Multiprotein signalling complexes: Regional assembly on heparan sulphate
, 2006 Heparan sulphate (HS) is an abundant component of cell surfaces and the extracellular matrix. It binds to a wide variety of peptide growth factors, morphogens, chemokines and extracellular matrix proteins (e.g. fibronectin) and many of these interactions
Gallagher, J. T.
core +10 more sources
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis
Hepatology, EarlyView., 2022 Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr +19 more
wiley +1 more source
Visualization of Multiprotein Complexes by Flow Cytometry [PDF]
Current Protocols in Immunology, 2009 Adam Schrum
exaly +2 more sources
Inflammasomes driven inflammation in lung cancer revisited: a short review
Exploration of Immunology, 2023 Lung cancer is the leading cause of cancer-related deaths worldwide. The main risk factor for lung cancer is exposure to chemicals present in cigarettes and atmospheric pollutants, which, among other mechanisms, can increase the risk of cancer by ...
Vitor Rodrigues da Costa +5 more
doaj +1 more source
Quis Custodiet Ipsos Custodes (Who Controls the Controllers)? Two Decades of Studies on HDAC9
Life, 2021 Understanding how an epigenetic regulator drives different cellular responses can be a tricky task. Very often, their activities are modulated by large multiprotein complexes, the composition of which is context- and time-dependent.
Claudio Brancolini +3 more
doaj +1 more source
Mass spectrometric analysis of pilus assembly, amyloid fibril formation, and membrane proteins in their native state [PDF]
, 2012 Structural analysis of proteins and their complexes is crucial to understanding protein function. This thesis demonstrates the application of mass spectrometry (MS) to the study of pilus assembly on Gram-negative bacteria and amyloid formation in ...
Leney, Aneika Corrine
core +6 more sources
Virtual and biophysical screening targeting the γ-tubulin complex--a new target for the inhibition of microtubule nucleation. [PDF]
PLoS ONE, 2013 Microtubules are the main constituents of mitotic spindles. They are nucleated in large amounts during spindle assembly, from multiprotein complexes containing γ-tubulin and associated γ-tubulin complex proteins (GCPs).
Olivier Cala +6 more
doaj +1 more source