Results 11 to 20 of about 61,024 (262)
Structure-based characterization of multiprotein complexes. [PDF]
Structure, 2014 Multiprotein complexes govern virtually all cellular processes. Their 3D structures provide important clues to their biological roles, especially through structural correlations among protein molecules and complexes. The detection of such correlations generally requires comprehensive searches in databases of known protein structures by means of ...
Wiederstein M +4 more
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Multiprotein GLI Transcriptional Complexes as Therapeutic Targets in Cancer
Life, 2022 The Hedgehog signaling pathway functions in both embryonic development and adult tissue homeostasis. Importantly, its aberrant activation is also implicated in the progression of multiple types of cancer, including basal cell carcinoma and ...
Fan Yang +4 more
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PsB Multiprotein Complex of [PDF]
Journal of Biological Chemistry, 1996 Vince McGuire, Stephen Alexander
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A Scalable Genome-Editing-Based Approach for Mapping Multiprotein Complexes in Human Cells
Cell Reports, 2015 Conventional affinity purification followed by mass spectrometry (AP-MS) analysis is a broadly applicable method used to decipher molecular interaction networks and infer protein function.
Mathieu Dalvai +7 more
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Multiprotein complex formation on the c‐myc promoter [PDF]
IUBMB Life, 1997 AbstractThe E2F element is a cis‐acting DNA sequence within the P2 promoter of the c‐myc proto‐oncogene. While it is required for optimal transcription, the multiprotein complexes formed on this site have not been well characterized. We show that in extracts of human glioblastoma cells and NIH3T3 fibroblasts, significant E2F transcription factor ...
Thomas J. Logan +2 more
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Disassembly of intact multiprotein complexes in the gas phase
Current Opinion in Structural Biology, 1999 The observation of multiprotein complexes by mass spectrometry formerly relied upon chemical cross-linking to maintain interactions. Recent technological developments have enabled the observation of intact macromolecular complexes without modification.
Carol V Robinson
exaly +3 more sources
The inner workings of the hydrazine synthase multiprotein complex [PDF]
Nature, 2015 Anaerobic ammonium oxidation (anammox) has a major role in the Earth's nitrogen cycle and is used in energy-efficient wastewater treatment. This bacterial process combines nitrite and ammonium to form dinitrogen (N2) gas, and has been estimated to synthesize up to 50% of the dinitrogen gas emitted into our atmosphere from the oceans.
Andreas Dietl +8 more
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Visualization of multiprotein complexes by flow cytometry. [PDF]
Curr Protoc Immunol, 2009 AbstractMultiprotein complexes and other protein‐protein interactions play important roles in virtually all cellular processes. Analysis of coimmunoprecipitation of protein complexes by flow cytometry (IP‐FCM, or “the fly‐p” method) provides a sensitive means to measure these interactions in the native/nondenatured state.
Schrum AG.
europepmc +4 more sources
UBE2O is a quality control factor for orphans of multiprotein complexes. [PDF]
Science, 2017 Yanagitani K, Juszkiewicz S, Hegde RS.
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Novel methods for studying multiprotein complexes in vivo. [PDF]
F1000Prime Rep, 2013 The current consensus is that the majority of proteins act in concert in the cell, as homo- and heteromeric complexes of two or more proteins that carry out discrete biological functions. A wide range of genomic, proteomic, biochemical, structural and biophotonic techniques have been employed over the years to study the protein-protein interactions ...
Mehta V, Trinkle-Mulcahy L.
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