Results 21 to 30 of about 61,024 (262)

Poxvirus multiprotein entry–fusion complex [PDF]

Proceedings of the National Academy of Sciences, 2005
Poxviruses have evolved elaborate mechanisms for cell entry, assembly, and exocytosis. Recently, four vaccinia virus membrane proteins, namely A21, A28, H2 and L5, were reported to be necessary for cell entry and virus-induced cell–cell fusion but not for virion morphogenesis or attachment of virus particles to cells.
Tatiana G, Senkevich, Suany, Ojeda, Alan, Townsley, Gretchen E, Nelson, Bernard, Moss   +4 more
openaire   +2 more sources

Inflammasomes driven inflammation in lung cancer revisited: a short review

Exploration of Immunology, 2023
Lung cancer is the leading cause of cancer-related deaths worldwide. The main risk factor for lung cancer is exposure to chemicals present in cigarettes and atmospheric pollutants, which, among other mechanisms, can increase the risk of cancer by ...
Vitor Rodrigues da Costa, Olívia Fonseca Souza, Michelli Ramires Teixeira, Anderson Lucas Alievi, Hugo Vigerelli, Rodrigo Pinheiro Araldi   +5 more
doaj   +1 more source

MAP kinases associate with high molecular weight multiprotein complexes. [PDF]

J Exp Bot, 2018
Plant responses to the environment and developmental processes are mediated by a complex signaling network. The Arabidopsis thaliana mitogen-activated protein kinases (MAPKs) MPK3 and MPK6 and their orthologs in other plants are shared signal transducers that respond to many developmental and environmental signals and thus represent highly connected ...
Bequette CJ, Hind SR, Pulliam S, Higgins R, Stratmann JW.   +4 more
europepmc   +4 more sources

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Quis Custodiet Ipsos Custodes (Who Controls the Controllers)? Two Decades of Studies on HDAC9

Life, 2021
Understanding how an epigenetic regulator drives different cellular responses can be a tricky task. Very often, their activities are modulated by large multiprotein complexes, the composition of which is context- and time-dependent.
Claudio Brancolini, Eros Di Giorgio, Luigi Formisano, Teresa Gagliano   +3 more
doaj   +1 more source

Genetic code expansion for multiprotein complex engineering [PDF]

Nature Methods, 2016
We present a baculovirus-based protein engineering method that enables site-specific introduction of unique functionalities in a eukaryotic protein complex recombinantly produced in insect cells. We demonstrate the versatility of this efficient and robust protein production platform, 'MultiBacTAG', (i) for the fluorescent labeling of target proteins ...
Christine Koehler, Paul F Sauter, Mirella Wawryszyn, Gemma Estrada Girona, Kapil Gupta, Jonathan J M Landry, Markus Hsi-Yang Fritz, Ksenija Radic, Jan-Erik Hoffmann, Zhuo A Chen, Juan Zou, Piau Siong Tan, Bence Galik, Sini Junttila, Peggy Stolt-Bergner, Giancarlo Pruneri, Attila Gyenesei, Carsten Schultz, Moritz Bosse Biskup, Hueseyin Besir, Vladimir Benes, Juri Rappsilber, Martin Jechlinger, Jan O Korbel, Imre Berger, Stefan Braese, Edward A Lemke   +26 more
openaire   +5 more sources

Identification and analysis of multi-protein complexes in placenta. [PDF]

PLoS ONE, 2013
Placental malfunction induces pregnancy disorders which contribute to life-threatening complications for both the mother and the fetus. Identification and characterization of placental multi-protein complexes is an important step to integratedly ...
Fuqiang Wang, Ling Wang, Zhiyang Xu, Gaolin Liang   +3 more
doaj   +1 more source

Fine-Tuning Multiprotein Complexes Using Small Molecules [PDF]

ACS Chemical Biology, 2012
Multiprotein complexes such as the transcriptional machinery, signaling hubs, and protein folding machines are typically composed of at least one enzyme combined with multiple non-enzymes. Often the components of these complexes are incorporated in a combinatorial manner, in which the ultimate composition of the system helps dictate the type, location,
Thompson, Andrea D, Dugan, Amanda, Gestwicki, Jason E, Mapp, Anna K   +3 more
openaire   +4 more sources

Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes

Pathogens, 2019
Flavivirus replication in host cells requires the formation of replication and assembly complexes on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. These complexes consist of an ER membrane, viral proteins, and host proteins.
Hussin A. Rothan, Mukesh Kumar
doaj   +1 more source

DONSON and FANCM associate with different replisomes distinguished by replication timing and chromatin domain

Nature Communications, 2020
Eukaryotic replisomes are multiprotein complexes. Here the authors reveal two distinct stressed replisomes, associated with DONSON and FANCM, displaying a bias in replication timing and chromatin domain.
Jing Zhang, Marina A. Bellani, Ryan C. James, Durga Pokharel, Yongqing Zhang, John J. Reynolds, Gavin S. McNee, Andrew P. Jackson, Grant S. Stewart, Michael M. Seidman   +9 more
doaj   +1 more source