Results 21 to 30 of about 40,419 (211)

Multiprotein Expression Strategy for Structural Biology of Eukaryotic Complexes [PDF]

Structure, 2007
SummaryThe concept of the cell as a collection of multisubunit protein machines is emerging as a cornerstone of modern biology, and molecular-level study of these machines in most cases will require recombinant production. Here, we present and validate a
Richmond, Timothy J., Fitzgerald, Daniel J, Richmond, Timothy J, Ralf Wellinger, Schaffitzel, Christiane, Daniel J. Fitzgerald, Berger, Imre, Christiane Schaffitzel, Wellinger, Ralf Erik, Wellinger, Ralf, Berger, Philipp, Philipp Berger, Imre Berger, Fitzgerald, Daniel J., Christoph Bieniossek, Timothy J. Richmond, Bieniossek, Christoph   +16 more
core   +7 more sources

Modulation of Nudt21 levels reveals dose-dependent roles of alternative polyadenylation in tissue regeneration [PDF]

Nature Communications
Stem cells continually self-renew and differentiate to sustain tissue homeostasis, yet the role of post-transcriptional mechanisms in guiding these processes remains incompletely understood.
Nikolaos Tsopoulidis, Masaki Yagi, Justin Brumbaugh, Shinya Ito, Víctor López-Soriano, Robert Morris, Yoseop Yoon, Kathleen A. Messemer, Kuan-Hung Lin, Eric F. Zaniewski, Rebecca Gorelov, Aaron J. Huebner, Amy J. Wagers, Hanno Hock, Günter Kramer, Bernd Bukau, Michael S. Hoetker, Yongsheng Shi, Wilhelm Haas, Konrad Hochedlinger   +19 more
doaj   +2 more sources

Biochemistry of Multiprotein HDAC Complexes

, 2006
Histone deacetylases perform an important role in the regulation of transcription by modifying the histone components of chromatin. This imparts specific restrictions to transcription and contributes to the proper coordination of gene expression.
Michael Scher, Reinberg, Danny, Vaquero, Alejandro, Alejandro Vaquero, Scher, Michael, Danny Reinberg   +5 more
core   +2 more sources

MAP kinases associate with high molecular weight multiprotein complexes [PDF]

Journal of Experimental Botany, 2018
Sarah R Hind, Johannes W Stratmann, Stratmann Johannes W   +2 more
exaly   +2 more sources

Multiprotein signalling complexes: Regional assembly on heparan sulphate

Biochemical Society Transactions, 2006
Heparan sulphate (HS) is an abundant component of cell surfaces and the extracellular matrix. It binds to a wide variety of peptide growth factors, morphogens, chemokines and extracellular matrix proteins (e.g. fibronectin) and many of these interactions
Gallagher, J. T.
core   +5 more sources

Automated unrestricted multigene recombineering for multiprotein complex production.

Nature Methods, 2009
International audienceStructural and functional studies of many multiprotein complexes depend on recombinant-protein overexpression. Rapid revision of expression experiments and diversification of the complexes are often crucial for success of these ...
Steinmetz, Michel O., Ian Collinson, Olieric, Natacha, Richmond, Timothy, J., Nie, Yan,, Michel O Steinmetz, Berger, Philipp, Romier, Christophe, Timothy J Richmond, Christoph Bieniossek, Christophe Romier, Collinson, Ian, Bieniossek, Christoph, Frey, Daniel, Richmond, Timothy J., Richmond, Timothy J, Schaffitzel, Christiane, Berger, Imre, Steinmetz, Michel, O., Christiane Schaffitzel, Steinmetz, Michel O, Natacha Olieric, Philipp Berger, Imre Berger, Nie, Yan, Daniel Frey, Yan Nie   +26 more
core   +4 more sources

Novel methods for studying multiprotein complexes in vivo. [PDF]

F1000Prime Rep, 2013
The current consensus is that the majority of proteins act in concert in the cell, as homo- and heteromeric complexes of two or more proteins that carry out discrete biological functions. A wide range of genomic, proteomic, biochemical, structural and biophotonic techniques have been employed over the years to study the protein-protein interactions ...
Mehta V, Trinkle-Mulcahy L.
europepmc   +4 more sources

Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis

Hepatology, EarlyView., 2022
Interleukin‐18 signaling promotes activation of hepatic stellate cells in mouse liver fibrosis. Abstract Background and Aims Nucleotide‐binding oligomerization domain‐like receptor‐family pyrin domain‐containing 3 (NLRP3) inflammasome activation has been shown to result in liver fibrosis.
Jana Knorr, Benedikt Kaufmann, Maria Eugenia Inzaugarat, Theresa Maria Holtmann, Lukas Geisler, Jana Hundertmark, Marlene Sophia Kohlhepp, Laela M. Boosheri, Daisy R. Chilin‐Fuentes, Amanda Birmingham, Kathleen M. Fisch, Joel D. Schilling, Sven H. Loosen, Christian Trautwein, Christoph Roderburg, Münevver Demir, Frank Tacke, Hal M. Hoffman, Ariel E. Feldstein, Alexander Wree   +19 more
wiley   +1 more source

Inflammasomes driven inflammation in lung cancer revisited: a short review

Exploration of Immunology, 2023
Lung cancer is the leading cause of cancer-related deaths worldwide. The main risk factor for lung cancer is exposure to chemicals present in cigarettes and atmospheric pollutants, which, among other mechanisms, can increase the risk of cancer by ...
Vitor Rodrigues da Costa, Olívia Fonseca Souza, Michelli Ramires Teixeira, Anderson Lucas Alievi, Hugo Vigerelli, Rodrigo Pinheiro Araldi   +5 more
doaj   +1 more source

Molecular basis for chromatin assembly and modification by multiprotein complexes. [PDF]

Protein Sci, 2019
Abstract: Epigenetic regulation of the chromatin landscape is often orchestrated through modulation of nucleosomes. Nucleosomes are composed of two copies each of the four core histones, H2A, H2B, H3, and H4, wrapped in ~150 bp of DNA. We focus this review on recent structural studies that further elucidate the mechanisms used by macromolecular ...
Ricketts MD, Han J, Szurgot MR, Marmorstein R.   +3 more
europepmc   +4 more sources