Results 31 to 40 of about 61,024 (262)
Virtual and biophysical screening targeting the γ-tubulin complex--a new target for the inhibition of microtubule nucleation. [PDF]
PLoS ONE, 2013 Microtubules are the main constituents of mitotic spindles. They are nucleated in large amounts during spindle assembly, from multiprotein complexes containing γ-tubulin and associated γ-tubulin complex proteins (GCPs).
Olivier Cala +6 more
doaj +1 more source
The MultiBac Baculovirus/Insect Cell Expression Vector System for Producing Complex Protein Biologics [PDF]
, 2016 Multiprotein complexes regulate most if not all cellular functions. Elucidating the structure and function of these complex cellular machines is essential for understanding biology.
Berger, Imre, Gupta, Kapil
core +2 more sources
Biological Procedures Online, 2002 There is accumulating evidence that membrane-bound receptors interact with many intracellular proteins. Multiprotein complexes associated with ionotropic receptors have been extensively characterized, but the identification of proteins interacting with G
Bécamel Carine +6 more
doaj +1 more source
, 2005 Background: With the increase in the number of genome sequencing projects, there is a concomitant exponential growth in the number of protein sequences whose function is still unknown.
MONTI, MARIA +3 more
core +1 more source
Purifi cation of Multiprotein Histone Acetyltransferase Complexes [PDF]
, 2011 The reversible acetylation of specific lysine residues on core histones regulates gene transcription in eukaryotes. Since the discovery of GCN5 as the first transcription-regulating histone acetyltransferase (HAT), a variety of HATs have now been identified and shown to acetylate different sites on histones as well as on non-histone proteins, including
Yuan-Liang, Wang +2 more
openaire +2 more sources
Cells, 2020 The aberrant function of chromatin regulatory networks (epigenetics) is a hallmark of cancer promoting oncogenic gene expression. A growing body of evidence suggests that the disruption of specific chromatin-associated protein complexes has therapeutic ...
Florian Perner, Scott A. Armstrong
doaj +1 more source
Assembly and regulation of γ-tubulin complexes [PDF]
Open Biology, 2018 Microtubules are major constituents of the cytoskeleton in all eukaryotic cells. They are essential for chromosome segregation during cell division, for directional intracellular transport and for building specialized cellular structures such as cilia or
Dorian Farache +3 more
doaj +1 more source
Identification of Mammalian Mediator Subunits with Similarities to Yeast Mediator Subunits Srb5, Srb6, Med11, and Rox3 [PDF]
, 2003 The Mediator is a multiprotein coactivator required for activation of RNA polymerase II transcription by DNA binding transactivators. We recently identified a mammalian homologue of yeast Mediator subunit Med8 and partially purified a Med8-containing ...
Banks, Charles A. S. +11 more
core +2 more sources
Geometric modeling of subcellular structures, organelles, and multiprotein complexes. [PDF]
Int J Numer Method Biomed Eng, 2012 SUMMARYRecently, the structure, function, stability, and dynamics of subcellular structures, organelles, and multiprotein complexes have emerged as a leading interest in structural biology. Geometric modeling not only provides visualizations of shapes for large biomolecular complexes but also fills the gap between structural information and theoretical
Feng X, Xia K, Tong Y, Wei GW.
europepmc +4 more sources
Baculovirus expression: tackling the complexity challenge [PDF]
, 2013 This article is made available for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source.
Barford, David +3 more
core +2 more sources