Results 31 to 40 of about 960,142 (193)

Nuclear Coregulatory Complexes in Tregs as Targets to Promote Anticancer Immune Responses

Frontiers in Immunology, 2022
T-regulatory (Treg) cells display considerable heterogeneity in their responses to various cancers. The functional differences among this cell type are heavily influenced by multiprotein nuclear complexes that control their gene expression.
Lanette M. Christensen, Wayne W. Hancock, Wayne W. Hancock   +2 more
doaj   +1 more source

The integration of signaling by multiprotein complexes containing Raf kinases [PDF]

, 2007
In vivo, eukaryotic cells are subjected simultaneously to a broad array of signals ranging from mitogens and inflammatory inputs to environmental stresses and developmental cues.
Kyriakis, John M., John M. Kyriakis
core   +1 more source

Membrane-embedded multiprotein complexes coproduced with GFP from the PprgH::gfp fusion.

, 2022
Membrane-embedded multiprotein complexes coproduced with GFP from the PprgH::gfp fusion.
Abram Aertsen (43457), Julien Mortier (5692604), Pilar Natalia Rodilla Ramirez (12369482), Malgorzata Sobota (12369479), Isabelle Hug (251572), Médéric Diard (267664), Andrea Rocker (7272395), Théo Gervais (12369488), Thomas Julou (407233), Tiphaine Haas (12369491), Alexander Cambré (12369485), Dany Chauvin (11851860), Delphine Cornillet (12369494)   +12 more
core   +1 more source

Mass Spectrometry-Based Characterization of the Virion Proteome, Phosphoproteome, and Associated Kinase Activity of Human Cytomegalovirus

Microorganisms, 2020
The assembly of human cytomegalovirus (HCMV) virions is an orchestrated process that requires, as an essential prerequisite, the complex crosstalk between viral structural proteins. Currently, however, the mechanisms governing the successive steps in the
Yohann Couté, Alexandra Kraut, Christine Zimmermann, Nicole Büscher, Anne-Marie Hesse, Christophe Bruley, Marco De Andrea, Christina Wangen, Friedrich Hahn, Manfred Marschall, Bodo Plachter   +10 more
doaj   +1 more source

Characterization of a multipurpose NS3 surface patch coordinating HCV replicase assembly and virion morphogenesis.

PLoS Pathogens, 2022
The hepatitis C virus (HCV) life cycle is highly regulated and characterized by a step-wise succession of interactions between viral and host cell proteins resulting in the assembly of macromolecular complexes, which catalyse genome replication and/or ...
Olaf Isken, Minh Tu Pham, Hella Schwanke, Felicia Schlotthauer, Ralf Bartenschlager, Norbert Tautz   +5 more
doaj   +1 more source

Editosome Accessory Factors KREPB9 and KREPB10 in Trypanosoma brucei [PDF]

, 2012
Multiprotein complexes, called editosomes, catalyze the uridine insertion and deletion RNA editing that forms translatable mitochondrial mRNAs in kinetoplastid parasites.
Acestor, Nathalie, Schnaufer, Achim; id_orcid, Stuart, Kenneth, Carnes, Jason, Lerch, Melissa, Guo, Xuemin   +5 more
core   +1 more source

Structural Biology of DNA Repair: Spatial Organisation of the Multicomponent Complexes of Nonhomologous End Joining

Journal of Nucleic Acids, 2010
Nonhomologous end joining (NHEJ) plays a major role in double-strand break DNA repair, which involves a series of steps mediated by multiprotein complexes.
Takashi Ochi, Bancinyane Lynn Sibanda, Qian Wu, Dimitri Y. Chirgadze, Victor M. Bolanos-Garcia, Tom L. Blundell   +5 more
doaj   +1 more source

Hypergraphs for predicting essential genes using multiprotein complex data [PDF]

, 2020
Protein–protein interactions are crucial in many biological pathways and facilitate cellular function. Investigating these interactions as a graph of pairwise interactions can help to gain a systemic understanding of cellular processes.
Deane, Charlotte, Reinert, Gesine, Klimm, Florian   +2 more
core   +1 more source

Distinct Cytosolic Complexes Containing the Type III Secretion System ATPase Resolved by Three-Dimensional Single-Molecule Tracking in Live Yersinia enterocolitica

Microbiology Spectrum, 2022
The membrane-embedded injectisome, the structural component of the virulence-associated type III secretion system (T3SS), is used by Gram-negative bacterial pathogens to inject species-specific effector proteins into eukaryotic host cells.
Joshua R. Prindle, Yibo Wang, Julian M. Rocha, Andreas Diepold, Andreas Gahlmann   +4 more
doaj   +1 more source

MacroBac: New Technologies for Robust and Efficient Large-Scale Production of Recombinant Multiprotein Complexes [PDF]

, 2017
Recombinant expression of large, multiprotein complexes is essential and often rate limiting for determining structural, biophysical, and biochemical properties of DNA repair, replication, transcription, and other key cellular processes.
Gradia, Scott D, Tainer, John A, Fuss, Jill O, Justin P. Ishida, Scott D. Gradia, Miaw-Sheue Tsai, Ishida, Justin P, Jill O. Fuss, John A. Tainer, Chris Jeans, Jeans, Chris, Tsai, Miaw-Sheue   +11 more
core   +1 more source