Results 21 to 30 of about 48,916 (224)

The Antidiabetic Drug Lobeglitazone Protects Mice From Lipogenesis-Induced Liver Injury via Mechanistic Target of Rapamycin Complex 1 Inhibition [PDF]

Frontiers in Endocrinology, 2018
Non-alcoholic fatty liver disease (NAFLD) is a metabolic disorder closely linked with type II diabetes (T2D). The progression of NAFLD is associated with the induction of lipogenesis through hyperactivation of the mechanistic target of rapamycin complex ...
Yu Seol Lee, Yu Seol Lee, Jeong Su Park, Da Hyun Lee, Da Hyun Lee, Dong-Kyu Lee, Sung Won Kwon, Sung Won Kwon, Byung-Wan Lee, Byung-Wan Lee, Byung-Wan Lee, Soo Han Bae   +11 more
doaj   +2 more sources

The mechanistic target of rapamycin complex 1 critically regulates the function of mononuclear phagocytes and promotes cardiac remodeling in acute ischemia. [PDF]

J Mol Cell Cardiol, 2021
Monocytes and macrophages are cellular forces that drive and resolve inflammation triggered by acute myocardial ischemia. One of the most important but least understood regulatory mechanisms is how these cells sense cues from the micro-milieu and integrate environmental signals with their response that eventually determines the outcome of myocardial ...
Chen G, Phan V, Luo X, Cao DJ.
europepmc   +3 more sources

Publisher Correction: Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1. [PDF]

Sci Rep, 2020
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Layoun A, Goldberg AA, Baig A, Eng M, Attias O, Nelson K, Carella A, Amberber N, Fielhaber JA, Joung KB, Schmeing TM, Han Y, Downey J, Divangahi M, Roux PP, Kristof AS.   +15 more
europepmc   +3 more sources

Mechanistic Target of Rapamycin Complex 1 (mTORC1) and mTORC2 as Key Signaling Intermediates in Mesenchymal Cell Activation. [PDF]

J Biol Chem, 2016
Fibrotic diseases display mesenchymal cell (MC) activation with pathologic deposition of matrix proteins such as collagen. Here we investigate the role of mTOR complex 1 (mTORC1) and mTORC2 in regulating MC collagen expression, a hallmark of fibrotic disease. Relative to normal MCs (non-Fib MCs), MCs derived from fibrotic human lung allografts (Fib-MCs)
Walker NM, Belloli EA, Stuckey L, Chan KM, Lin J, Lynch W, Chang A, Mazzoni SM, Fingar DC, Lama VN.   +9 more
europepmc   +4 more sources

Overactivation of hepatic mechanistic target of rapamycin kinase complex 1 (mTORC1) is associated with low transcriptional activity of transcription factor EB and lysosomal dysfunction in dairy cows with clinical ketosis

Journal of Dairy Science, 2022
: Ketosis occurs most frequently in the peripartal period and is associated with liver injury and steatosis. Lysosomes serve as the terminal degradative station and contribute to liver homeostasis through their role in the digestion of dysfunctional ...
Zhiyuan Fang, Xinwei Li, Shu Wang, Qianming Jiang, Juan J. Loor, Xiuhuan Jiang, Lingxue Ju, Hao Yu, Taiyu Shen, Men Chen, Yuxiang Song, Zhe Wang, Xiliang Du, Guowen Liu   +13 more
doaj   +3 more sources

Mechanistic/mammalian target of rapamycin complex 1 (mTORC1) signaling is involved in phagocytosis activation during THP-1 cell differentiation

Journal of Veterinary Medical Science, 2023
Mechanistic/mammalian target of rapamycin complex 1 (mTORC1) is a serine/threonine kinase that plays a major role in cell metabolism. Although mTORC1 inhibitors are known to exert immunosuppressive effects, their effects on immune cells are not fully understood.
MUROKAWA, Hiroka, EGUSA, Karin, SHIBUTANI, Shusaku, IWATA, Hiroyuki   +3 more
exaly   +3 more sources

Endoplasmic reticulum stress-induced apoptosis in intestinal epithelial cells: a feed-back regulation by mechanistic target of rapamycin complex 1 (mTORC1) [PDF]

Journal of Animal Science and Biotechnology, 2018
Background Endoplasmic reticulum (ER) stress is associated with multiple pathological processes of intestinal diseases. Despite a critical role of mechanistic target of rapamycin complex 1 (mTORC1) in regulating cellular stress response, the crosstalk ...
Yun Ji, Xuan Luo, Ying Yang, Zhaolai Dai, Guoyao Wu, Zhenlong Wu   +5 more
doaj   +2 more sources

Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast-twitch muscle in rats. [PDF]

Physiol Rep
AbstractFast‐twitch muscles are less susceptible to disuse atrophy, activate the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway, and increase protein synthesis under prolonged muscle disuse conditions. However, the mechanism underlying prolonged muscle disuse‐induced mTORC1 signaling activation remains unclear.
Uda M, Yoshihara T, Ichinoseki-Sekine N, Baba T.   +3 more
europepmc   +4 more sources

Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish [PDF]

Disease Models & Mechanisms, 2014
Truncating mutations in adenomatous polyposis coli (APC) are strongly linked to colorectal cancers. APC is a negative regulator of the Wnt pathway and constitutive Wnt activation mediated by enhanced Wnt–β-catenin target gene activation is believed to be
Alexander J. Valvezan, Jian Huang, Christopher J. Lengner, Michael Pack, Peter S. Klein   +4 more
doaj   +3 more sources

Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting. [PDF]

Adv Nutr, 2016
Stunting is the best summary measure of chronic malnutrition in children. Approximately one-quarter of children under age 5 worldwide are stunted. Lipid-based or micronutrient supplementation has little to no impact in reducing stunting, which suggests that other critical dietary nutrients are missing.
Semba RD, Trehan I, Gonzalez-Freire M, Kraemer K, Moaddel R, Ordiz MI, Ferrucci L, Manary MJ.   +7 more
europepmc   +4 more sources