Results 41 to 50 of about 48,916 (224)
mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome
Nature Communications, 2022 Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome.
Zhengping Huang +30 more
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DN200434 Inhibits Vascular Smooth Muscle Cell Proliferation and Prevents Neointima Formation in Mice after Carotid Artery Ligation [PDF]
Endocrinology and Metabolism, 2022 Background Excessive proliferation and migration of vascular smooth muscle cells (VSMCs), which contributes to the development of occlusive vascular diseases, requires elevated mitochondrial oxidative phosphorylation to meet the increased requirements ...
Sudeep Kumar +9 more
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Journal of Lipid Research, 2020 The rise of drug-resistant tuberculosis poses a major risk to public health. Statins, which inhibit both cholesterol biosynthesis and protein prenylation branches of the mevalonate pathway, increase anti-tubercular antibiotic efficacy in animal models ...
Natalie Bruiners +6 more
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RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial
Translational Medicine of Aging, 2020 The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly.
Matt Kaeberlein
doaj +1 more source
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP
Molecular Brain, 2023 The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in gating the production of new proteins thereby
Shane Wiebe +7 more
doaj +1 more source
Nature Communications, 2021 The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and show ...
Celia de la Calle Arregui +18 more
doaj +1 more source
The Lancet. Healthy Longevity, 2021 Summary: COVID-19 disproportionately affects older people, with likelihood of severe complications and death mirroring that of other age-associated diseases.
Evelyne Bischof, MD +3 more
doaj +1 more source
PLoS Pathogens, 2022 Previous studies have shown that the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway has antiviral functions or is beneficial for viral replication, however, the detail mechanisms by which mTORC1 enhances viral infection remain ...
Pan-Pan Hong +4 more
doaj +1 more source
The crosstalk between MYC and mTORC1 during osteoclastogenesis
Frontiers in Cell and Developmental Biology, 2022 Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption.
Seyeon Bae +10 more
doaj +1 more source
RhoA regulates the mechanistic target of rapamycin complex 1 (mTORC1)
The FASEB Journal, 2013 The mTORC1 signaling pathway plays a vital role in integrating signals generated by hormones and nutrients to control cell growth and metabolism. The point of integration of many of the input signals from hormones is the GTPase activating protein complex TSC1/2 that acts to repress the mTORC1‐stimulatory activity of the small GTPase Rheb.
Bradley S. Gordon +5 more
openaire +1 more source