Results 41 to 50 of about 68,619 (285)

Effects of hindlimb unloading on the mevalonate and mechanistic target of rapamycin complex 1 signaling pathways in a fast-twitch muscle in rats. [PDF]

Physiol Rep
Uda M, Yoshihara T, Ichinoseki-Sekine N, Baba T.   +3 more
europepmc   +3 more sources

Prenatal Mechanistic Target of Rapamycin Complex 1 (m TORC1) Inhibition by Rapamycin Treatment of Pregnant Mice Causes Intrauterine Growth Restriction and Alters Postnatal Cardiac Growth, Morphology, and Function. [PDF]

J Am Heart Assoc, 2017
Hennig M, Fiedler S, Jux C, Thierfelder L, Drenckhahn JD.   +4 more
europepmc   +2 more sources

Reactivation of cocaine contextual memory engages mechanistic target of rapamycin/S6 kinase 1 signaling

Frontiers in Pharmacology, 2022
Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen ...
Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald   +7 more
doaj   +1 more source

Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop

Frontiers in Cell and Developmental Biology, 2021
In recent years, an increasing number of studies have reported that long noncoding RNAs (lncRNAs) play crucial roles in breast cancer (BC) progression and metastasis. Another study group of our research center reported that lncRNA HCG18 was one of the 30
Xu Liu, Kun Qiao, Kaiyuan Zhu, Xianglan Li, Chunbo Zhao, Jiaqi Li, Dawei Feng, Yu Fang, Peng Wang, Cheng Qian, Wenbo Qiao   +10 more
doaj   +1 more source

Inhibition of the mTORC1 pathway alleviates adipose tissue fibrosis

Heliyon, 2023
Background: Adipose fibrosis is a major factor of adipose dysfunction, which causes metabolic dysfunction during obesity, but its molecular mechanisms are poorly understood.
Sa Gong, Chang Li, Qingyang Leng, Chongxiao Liu, Yi Zhu, Hongli Zhang, Xiaohua Li   +6 more
doaj   +1 more source

Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting. [PDF]

Adv Nutr, 2016
Semba RD, Trehan I, Gonzalez-Freire M, Kraemer K, Moaddel R, Ordiz MI, Ferrucci L, Manary MJ.   +7 more
europepmc   +3 more sources

Progranulin depletion inhibits proliferation via the transforming growth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells

Heliyon, 2021
Progranulin is an autocrine growth factor that promotes proliferation, migration, invasion, and chemoresistance of various cancer cells. These mechanisms mainly depend on the protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway.
Kuniaki Yabe, Yasuko Yamamoto, Masao Takemura, Takeshi Hara, Hisashi Tsurumi, Ginette Serrero, Toshitaka Nabeshima, Kuniaki Saito   +7 more
doaj   +1 more source

The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back

Frontiers in Cell and Developmental Biology, 2021
The tuberous sclerosis protein complex (TSC complex) is a key integrator of metabolic signals and cellular stress. In response to nutrient shortage and stresses, the TSC complex inhibits the mechanistic target of rapamycin complex 1 (mTORC1) at the ...
Ulrike Rehbein, Mirja Tamara Prentzell, Mirja Tamara Prentzell, Marti Cadena Sandoval, Marti Cadena Sandoval, Alexander Martin Heberle, Alexander Martin Heberle, Elizabeth P. Henske, Christiane A. Opitz, Christiane A. Opitz, Kathrin Thedieck, Kathrin Thedieck, Kathrin Thedieck   +12 more
doaj   +1 more source

Arterial wall fibrosis in Takayasu arteritis and its potential for therapeutic modulation

Frontiers in Immunology, 2023
Arterial wall damage in Takayasu arteritis (TAK) can progress despite immunosuppressive therapy. Vascular fibrosis is more prominent in TAK than in giant cell arteritis (GCA).
Durga Prasanna Misra, Kritika Singh, Aman Sharma, Vikas Agarwal   +3 more
doaj   +1 more source

mTORC1 links pathology in experimental models of Still’s disease and macrophage activation syndrome

Nature Communications, 2022
Still’s disease is an inflammatory syndrome linked to the development of further immune dysregulation and hypercytokinaemia termed macrophage activation syndrome.
Zhengping Huang, Xiaomeng You, Liang Chen, Yan Du, Kailey Brodeur, Hyuk Jee, Qiang Wang, Grace Linder, Roxane Darbousset, Pierre Cunin, Margaret H. Chang, Alexandra Wactor, Brian M. Wauford, Marc J. C. Todd, Kevin Wei, Ying Li, Anais Levescot, Yoichiro Iwakura, Virginia Pascual, Nicole E. Baldwin, Pierre Quartier, Tianwang Li, Maria T. Gianatasio, Robert P. Hasserjian, Lauren A. Henderson, David B. Sykes, Elizabeth D. Mellins, Scott W. Canna, Julia F. Charles, Peter A. Nigrovic, Pui Y. Lee   +30 more
doaj   +1 more source