Results 51 to 60 of about 48,916 (224)

Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch [PDF]

Diabetes, 2014
Interconversion of white and brown adipocytes occurs between anabolic and catabolic states. The molecular mechanism regulating this phenotypic switch remains largely unknown. This study explores the role of tuberous sclerosis complex 1 (TSC1)–mechanistic target of rapamycin (mTOR) signaling in the conversion of brown to white adipose tissue (WAT).
Xinxin, Xiang, He, Lan, Hong, Tang, Fang, Yuan, Yanhui, Xu, Jing, Zhao, Yin, Li, Weizhen, Zhang   +7 more
openaire   +2 more sources

A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis

Molecular & Cellular Oncology, 2021
Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj   +1 more source

Autophagy regulates rRNA synthesis

Nucleus, 2022
Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
doaj   +1 more source

Acute Elevation of Renal Perfusion Pressure Activates Mechanistic Target of Rapamycin Complex 1 in Rats

The FASEB Journal, 2021
We have recently reported that the chronic elevation of renal perfusion pressure (RPP) drives the infiltration of renal inflammatory cells in two models of hypertension, the Dahl salt‐sensitive (SS) rats fed a high‐salt diet and Sprague‐Dawley (SD) rats infused with Angiotensin II.
Satoshi Shimada, Vikash Kumar, Chun Yang, David Mattson, Allen Cowley   +4 more
openaire   +1 more source

Insulin potentiates essential amino acids effects on mechanistic target of rapamycin complex 1 signaling in MAC-T cells [PDF]

Journal of Dairy Science, 2020
Different models of lactation offer conflicting evidence as to whether insulin signaling is required for AA to stimulate mechanistic target of rapamycin complex 1 (mTORC1) activity. We hypothesized that insulin potentiates essential AA stimulation of mTORC1 activity in the MAC-T mammary epithelial cell line.
Virginia L. Pszczolkowski, Jun Zhang, Kayleigh A. Pignato, Emma J. Meyer, Madison M. Kurth, Amy Lin, Sebastian I. Arriola Apelo   +6 more
openaire   +2 more sources

Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity

GeroScience, 2020
Species longevity varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of longevity could converge in the mammalian target of rapamycin (mTOR) signalling pathway.
Mota Martorell, Natàlia, Jové Font, Mariona, Pradas Barriga, Irene, Berdún Hernández, Rebeca, Sanchez, Isabel, Naudí i Farré, Alba, Garí Marsol, Eloi, Barja, Gustavo, Pamplona Gras, Reinald   +8 more
openaire   +3 more sources

Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance The mechanistic or mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that integrates various environmental signals/cues to regulate cell growth, proliferation, metabolism, and survival.
Jinwook, Shin, Shang, Wang, Wenhai, Deng, Jinhong, Wu, Jimin, Gao, Xiao-Ping, Zhong   +5 more
openaire   +2 more sources

Eugenol attenuates paclitaxel-induced cardiotoxicity by modulating autophagy-related markers in rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Paclitaxel (PTX) is a commonly used chemotherapeutic agent that causes cardiotoxicity characterized by oxidative stress, inflammation, and mitochondrial dysfunction, which disrupts autophagy and apoptosis in cardiomyocytes.
Halime Tozak Yıldız, Sadık Küçükgünay, Oya Korkmaz, Seda Koçak, Mustafa Numan Bucak   +4 more
doaj   +1 more source

Mechanistic Target of Rapamycin Complex 1 (mTORC1)-mediated Phosphorylation Is Governed by Competition between Substrates for Interaction with Raptor [PDF]

Journal of Biological Chemistry, 2013
In this study, the interaction of mTORC1 with its downstream targets p70S6K1 and 4E-BP1 was evaluated in both mouse liver and mouse embryonic fibroblasts following combined disruption of the genes encoding 4E-BP1 and 4E-BP2. Phosphorylation of p70S6K1 was dramatically elevated in the livers of mice lacking 4E-BP1 and 4E-BP2 following feeding-induced ...
Michael D, Dennis, Scot R, Kimball, Leonard S, Jefferson   +2 more
openaire   +2 more sources

Dietary sodium sulphate supplementation during mid-to-late gestation improves placental angiogenesis, bile acid metabolism, and serum amino acid concentrations of sows

Animal
Sulphate plays a vital role in the growth and development of the foetus. Sodium sulphate (Na2SO4) is utilised as a dietary protein nutrient factor and helps replenish sulphur elements in livestock and poultry.
R. Zhou, L. Zhe, S.S. Lai, H.M. Wen, L. Hu, X.L. Zhang, Y. Zhuo, S.Y. Xu, Y. Lin, B. Feng, L.Q. Che, D. Wu, Z.F. Fang   +12 more
doaj   +1 more source