Results 51 to 60 of about 47,262 (255)

Responses to hypoxia via mTOR : role in endothelial cell proliferation and HIF-1[alpha] stabilization [PDF]

, 2005
Ischemic cardiovascular disease and cancer are life-threatening disorders in human mortality. Intensive studies on the etiology of and therapeutics for the diseases are ongoing.
Li, Weimin
core   +1 more source

Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP

Molecular Brain, 2023
The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in gating the production of new proteins thereby
Shane Wiebe, Ziying Huang, Reese Jalal Ladak, Agnieszka Skalecka, Roberta Cagnetta, Jean-Claude Lacaille, Argel Aguilar-Valles, Nahum Sonenberg   +7 more
doaj   +1 more source

Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle [PDF]

, 2017
The mechanistic target of rapamycin (mTOR) is a central mediator of protein synthesis in skeletal muscle. We utilized immunofluorescence approaches to study mTOR cellular distribution and protein-protein co-localisation in human skeletal muscle in the ...
Hamilton, D. Lee, Hornberger, Troy A, Jessica R. Dent, D. Lee Hamilton, Hodson, Nathan, Mary F. O’Leary, Moore, Daniel, Nathan Hodson, O'Leary, Mary F, Hornberger, Troy, Lawrence L. Spriet, Daniel R. Moore, Ward, Carl, Heigenhauser, George J F, Spriet, Lawrence, Andrew Philp, Troy A. Hornberger, Heigenhauser, George, Yann-Gaël Gangloff, Sarkar, Sovan, O’Leary, Mary, Shaw, Andrew, Hornberger, Troy A., Andrew M. Shaw, Shaw, Andy, Zhe Song, Philp, Andrew, Spriet, Lawrence L, Moore, Daniel R, Heigenhauser, George J., Sovan Sarkar, Song, Zhe, Dent, Jessica R, Hodson, Nathan; id_orcid, Hamilton, David Lee, Dent, Jessica, Gangloff, Yann-Gael, Moore, Daniel R., Shaw, Andrew M, George J. Heigenhauser, Carl Ward, Spriet, Lawrence L.   +41 more
core   +1 more source

Limited survival and impaired hepatic fasting metabolism in mice with constitutive Rag GTPase signaling

Nature Communications, 2021
The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and show ...
Celia de la Calle Arregui, Ana Belén Plata-Gómez, Nerea Deleyto-Seldas, Fernando García, Ana Ortega-Molina, Julio Abril-Garrido, Elena Rodriguez, Ivan Nemazanyy, Laura Tribouillard, Alba de Martino, Eduardo Caleiras, Ramón Campos-Olivas, Francisca Mulero, Mathieu Laplante, Javier Muñoz, Mario Pende, Guadalupe Sabio, David M. Sabatini, Alejo Efeyan   +18 more
doaj   +1 more source

Elucidating the role of DEPTOR in Alzheimer's disease [PDF]

, 2014
This article has been made available through the Brunel Open Access Publishing Fund.The mammalian or mechanistic target of rapamycin (mTOR) is a Ser/Thr protein kinase that, in response to nutrient stimulation, regulates cellular growth, proliferation ...
Karteris, E, Zachariades, E, Rogers-Broadway, K-R, Davies, J, Davies, Julie   +4 more
core   +1 more source

White spot syndrome virus directly activates mTORC1 signaling to facilitate its replication via polymeric immunoglobulin receptor-mediated infection in shrimp.

PLoS Pathogens, 2022
Previous studies have shown that the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway has antiviral functions or is beneficial for viral replication, however, the detail mechanisms by which mTORC1 enhances viral infection remain ...
Pan-Pan Hong, Cang Li, Guo-Juan Niu, Xiao-Fan Zhao, Jin-Xing Wang   +4 more
doaj   +1 more source

The potential of rapalogs to enhance resilience against SARS-CoV-2 infection and reduce the severity of COVID-19

The Lancet. Healthy Longevity, 2021
Summary: COVID-19 disproportionately affects older people, with likelihood of severe complications and death mirroring that of other age-associated diseases.
Evelyne Bischof, MD, Richard C Siow, PhD, Alex Zhavoronkov, PhD, Matt Kaeberlein, ProfPhD   +3 more
doaj   +1 more source

A mTORC1-mediated cyst(e)ine sensing mechanism governing GPX4 synthesis and ferroptosis

Molecular & Cellular Oncology, 2021
Ferroptosis is a cell death mechanism triggered by lipid peroxidation. Our recent study linked cyst(e)ine availability with glutathione peroxidase 4 (GPX4) protein synthesis and ferroptosis mitigation via a Rag-mechanistic target of rapamycin complex 1 ...
Yuelong Yan, Guang Lei, Boyi Gan
doaj   +1 more source

Autophagy regulates rRNA synthesis

Nucleus, 2022
Autophagy has emerged as a key regulator of cell metabolism. Recently, we have demonstrated that autophagy is involved in RNA metabolism by regulating ribosomal RNA (rRNA) synthesis.
Yinfeng Xu, Wei Wan
doaj   +1 more source

RhoA regulates the mechanistic target of rapamycin complex 1 (mTORC1)

The FASEB Journal, 2013
The mTORC1 signaling pathway plays a vital role in integrating signals generated by hormones and nutrients to control cell growth and metabolism. The point of integration of many of the input signals from hormones is the GTPase activating protein complex TSC1/2 that acts to repress the mTORC1‐stimulatory activity of the small GTPase Rheb.
Bradley S. Gordon, Abid A. Kazi, Catherine S. Coleman, Leonard S. Jefferson, Vincent Chau, Scot R. Kimball   +5 more
openaire   +1 more source