Results 51 to 60 of about 68,619 (285)
DN200434 Inhibits Vascular Smooth Muscle Cell Proliferation and Prevents Neointima Formation in Mice after Carotid Artery Ligation [PDF]
Endocrinology and Metabolism, 2022 Background Excessive proliferation and migration of vascular smooth muscle cells (VSMCs), which contributes to the development of occlusive vascular diseases, requires elevated mitochondrial oxidative phosphorylation to meet the increased requirements ...
Sudeep Kumar +9 more
doaj +1 more source
TAK1-dependent autophagy: A suppressor of fatty liver disease and hepatic oncogenesis. [PDF]
, 2014 In addition to regulating the activation of nuclear factor (NF)-κB and c-Jun N-terminal kinase (JNK), TGF-β activated kinase 1 (TAK1) also upregulates the activation of AMP-activated protein kinase (AMPK) and autophagy.
Seki, Ekihiro
core +2 more sources
Journal of Lipid Research, 2020 The rise of drug-resistant tuberculosis poses a major risk to public health. Statins, which inhibit both cholesterol biosynthesis and protein prenylation branches of the mevalonate pathway, increase anti-tubercular antibiotic efficacy in animal models ...
Natalie Bruiners +6 more
doaj +1 more source
RTB101 and immune function in the elderly: Interpreting an unsuccessful clinical trial
Translational Medicine of Aging, 2020 The biopharmaceutical company resTORbio, Inc. Recently announced termination of a phase 3 clinical trial evaluating the ability of the drug RTB101 to improve immune function in the elderly.
Matt Kaeberlein
doaj +1 more source
Nature Communications, 2021 The mechanistic target of rapamycin complex 1 (mTORC1) integrates nutrient and hormonal signals to control metabolism. Here the authors investigate the effects of constitutive nutrient signaling through genetic activation of RagA in adult mice and show ...
Celia de la Calle Arregui +18 more
doaj +1 more source
Targeting protein homeostasis with nelfinavir/salinomycin dual therapy effectively [PDF]
, 2017 Uncontrolled cell growth in Tuberous Sclerosis Complex occurs due to inappropriate activation of mechanistic (mammalian) target of rapamycin complex 1 (mTORC1).
Dunlop, Elaine A +4 more
core +1 more source
The FASEB Journal, 2021 We have recently reported that the chronic elevation of renal perfusion pressure (RPP) drives the infiltration of renal inflammatory cells in two models of hypertension, the Dahl salt‐sensitive (SS) rats fed a high‐salt diet and Sprague‐Dawley (SD) rats infused with Angiotensin II.
Satoshi Shimada +4 more
openaire +1 more source
Cell-type-specific translational control of spatial working memory by the cap-binding protein 4EHP
Molecular Brain, 2023 The consolidation of learned information into long-lasting memories requires the strengthening of synaptic connections through de novo protein synthesis. Translation initiation factors play a cardinal role in gating the production of new proteins thereby
Shane Wiebe +7 more
doaj +1 more source
The Lancet. Healthy Longevity, 2021 Summary: COVID-19 disproportionately affects older people, with likelihood of severe complications and death mirroring that of other age-associated diseases.
Evelyne Bischof, MD +3 more
doaj +1 more source
PLoS Pathogens, 2022 Previous studies have shown that the mechanistic target of rapamycin complex 1 (mTORC1) signaling pathway has antiviral functions or is beneficial for viral replication, however, the detail mechanisms by which mTORC1 enhances viral infection remain ...
Pan-Pan Hong +4 more
doaj +1 more source