Results 61 to 70 of about 47,262 (255)

Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch [PDF]

Diabetes, 2014
Interconversion of white and brown adipocytes occurs between anabolic and catabolic states. The molecular mechanism regulating this phenotypic switch remains largely unknown. This study explores the role of tuberous sclerosis complex 1 (TSC1)–mechanistic target of rapamycin (mTOR) signaling in the conversion of brown to white adipose tissue (WAT).
Xinxin, Xiang, He, Lan, Hong, Tang, Fang, Yuan, Yanhui, Xu, Jing, Zhao, Yin, Li, Weizhen, Zhang   +7 more
openaire   +2 more sources

The crosstalk between MYC and mTORC1 during osteoclastogenesis

Frontiers in Cell and Developmental Biology, 2022
Osteoclasts are bone-resorbing cells that undergo extensive changes in morphology throughout their differentiation. Altered osteoclast differentiation and activity lead to changes in pathological bone resorption.
Seyeon Bae, Seyeon Bae, Brian Oh, Jefferson Tsai, Peter Sang Uk Park, Matthew Blake Greenblatt, Eugenia G. Giannopoulou, Eugenia G. Giannopoulou, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min, Kyung-Hyun Park-Min   +10 more
doaj   +1 more source

Acute Elevation of Renal Perfusion Pressure Activates Mechanistic Target of Rapamycin Complex 1 in Rats

The FASEB Journal, 2021
We have recently reported that the chronic elevation of renal perfusion pressure (RPP) drives the infiltration of renal inflammatory cells in two models of hypertension, the Dahl salt‐sensitive (SS) rats fed a high‐salt diet and Sprague‐Dawley (SD) rats infused with Angiotensin II.
Satoshi Shimada, Vikash Kumar, Chun Yang, David Mattson, Allen Cowley   +4 more
openaire   +1 more source

Insulin potentiates essential amino acids effects on mechanistic target of rapamycin complex 1 signaling in MAC-T cells [PDF]

Journal of Dairy Science, 2020
Different models of lactation offer conflicting evidence as to whether insulin signaling is required for AA to stimulate mechanistic target of rapamycin complex 1 (mTORC1) activity. We hypothesized that insulin potentiates essential AA stimulation of mTORC1 activity in the MAC-T mammary epithelial cell line.
Virginia L. Pszczolkowski, Jun Zhang, Kayleigh A. Pignato, Emma J. Meyer, Madison M. Kurth, Amy Lin, Sebastian I. Arriola Apelo   +6 more
openaire   +2 more sources

Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity

GeroScience, 2020
Species longevity varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of longevity could converge in the mammalian target of rapamycin (mTOR) signalling pathway.
Mota Martorell, Natàlia, Jové Font, Mariona, Pradas Barriga, Irene, Berdún Hernández, Rebeca, Sanchez, Isabel, Naudí i Farré, Alba, Garí Marsol, Eloi, Barja, Gustavo, Pamplona Gras, Reinald   +8 more
openaire   +3 more sources

Eugenol attenuates paclitaxel-induced cardiotoxicity by modulating autophagy-related markers in rats [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Paclitaxel (PTX) is a commonly used chemotherapeutic agent that causes cardiotoxicity characterized by oxidative stress, inflammation, and mitochondrial dysfunction, which disrupts autophagy and apoptosis in cardiomyocytes.
Halime Tozak Yıldız, Sadık Küçükgünay, Oya Korkmaz, Seda Koçak, Mustafa Numan Bucak   +4 more
doaj   +1 more source

Dietary sodium sulphate supplementation during mid-to-late gestation improves placental angiogenesis, bile acid metabolism, and serum amino acid concentrations of sows

Animal
Sulphate plays a vital role in the growth and development of the foetus. Sodium sulphate (Na2SO4) is utilised as a dietary protein nutrient factor and helps replenish sulphur elements in livestock and poultry.
R. Zhou, L. Zhe, S.S. Lai, H.M. Wen, L. Hu, X.L. Zhang, Y. Zhuo, S.Y. Xu, Y. Lin, B. Feng, L.Q. Che, D. Wu, Z.F. Fang   +12 more
doaj   +1 more source

Resolution of depression: Antidepressant actions of resolvins

Neuroscience Research
Major depressive disorder, one of the most widespread mental illnesses, brings about enormous individual and socioeconomic consequences. Conventional monoaminergic antidepressants require weeks to months to produce a therapeutic response, and ...
Satoshi Deyama, Katsuyuki Kaneda, Masabumi Minami   +2 more
doaj   +1 more source

The sensitivity of mTORC1 signaling activation renders tissue regenerative capacity

Cell Regeneration, 2023
A better understanding of how and why the regenerative capacity differs among species will not only provide insights into the regeneration process but also hold value for the development of regenerative medicine and the improvement of healing procedures.
Hanyu Dou, Jianzhou Li, Taomin Huang, Xiaolei Ding   +3 more
doaj   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source