Results 71 to 80 of about 68,619 (285)

Targeting carbonic anhydrase IX improves the anti-cancer efficacy of mTOR inhibitors. [PDF]

, 2016
The inhibition of the mechanistic target of rapamycin complex 1 (mTORC1) by chemical inhibitors, such as rapamycin, has demonstrated anti-cancer activity in preclinical and clinical trials.
Datta, D., Demartines, N., Dormond, O., Faes, S., Horlbeck, J., Letovanec, I., Planche, A., Pythoud, C., Riggi, N., Santoro, T., Stehle, J.C., Uldry, E.   +11 more
core   +1 more source

Insulin potentiates essential amino acids effects on mechanistic target of rapamycin complex 1 signaling in MAC-T cells [PDF]

Journal of Dairy Science, 2020
Different models of lactation offer conflicting evidence as to whether insulin signaling is required for AA to stimulate mechanistic target of rapamycin complex 1 (mTORC1) activity. We hypothesized that insulin potentiates essential AA stimulation of mTORC1 activity in the MAC-T mammary epithelial cell line.
Virginia L. Pszczolkowski, Jun Zhang, Kayleigh A. Pignato, Emma J. Meyer, Madison M. Kurth, Amy Lin, Sebastian I. Arriola Apelo   +6 more
openaire   +2 more sources

Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity. [PDF]

, 2014
Glycogen and lipids are major storage forms of energy that are tightly regulated by hormones and metabolic signals. We demonstrate that feeding mice a high-fat diet (HFD) increases hepatic glycogen due to increased expression of the glycogenic ...
Bridges, Dave, Chang, Louise, Cheng, Alan, Downes, Michael, Evans, Ronald M, Fisher, Kaleigh, Liddle, Christopher, Lin, Jiandie D, Lu, Binbin, Meng, Zhuo-Xian, Saltiel, Alan R, Yang, Yemen, Yu, Ruth T   +12 more
core   +2 more sources

GSK3-mediated raptor phosphorylation supports amino acid-dependent Q2 mTORC1-directed signalling [PDF]

, 2015
The mammalian or mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) is a ubiquitously expressed multimeric protein kinase complex that integrates nutrient and growth factor signals for the co-ordinated regulation of cellular metabolism and cell ...
Alan Prescott, Averous, Avruch, Azoulay-Alfaguter, Bain, Bar-Peled, Bar-Peled, Bradford, Carriere, Carriere, Clare Stretton, Coghlan, Cross, Demetriades, Dibble, Doble, Fonseca, Foster, Frey, Ganley, Garcia-Martinez, Gwinn, Gwinn, Hajduch, Hara, Harinder S. Hundal, Hosokawa, Ian G. Ganley, Inoki, Inoki, Inoki, Jewell, Jung, Kelleher, Kim, Kim, Kwak, Lipina, MacAulay, Marchand, Martina, Meijer, Menon, Michael J. Munson, Oshiro, Oshiro, Parr, Peter M. Taylor, Pfaffl, Ramirez-Valle, Rebsamen, Sancak, Shin, Smith, Stretton, Sutherland, Thorsten M. Hoffmann, Wang, Wang, Yoon, Zoncu   +60 more
core   +3 more sources

Identification of regions critical for the integrity of the TSC1-TSC2-TBC1D7 complex [PDF]

, 2014
The TSC1-TSC2-TBC1D7 complex is an important negative regulator of the mechanistic target of rapamycin complex 1 that controls cell growth in response to environmental cues.
Halley, D.J.J. (Dicky), Hoogeveen-Westerveld, M. (Marianne), Kikkawa, U. (Ushio), Maat-Kievit, A.A. (Anneke), Nakashima, A. (Akio), Nellist, M.D. (Mark), Ouweland, A.M.W. (Ans) van den, Santiago Lima, A.J. (Arthur Jorge)   +7 more
core   +1 more source

Gene expression and regulatory factors of the mechanistic target of rapamycin (mTOR) complex 1 predict mammalian longevity

GeroScience, 2020
Species longevity varies significantly across animal species, but the underlying molecular mechanisms remain poorly understood. Recent studies and omics approaches suggest that phenotypic traits of longevity could converge in the mammalian target of rapamycin (mTOR) signalling pathway.
Mota Martorell, Natàlia, Jové Font, Mariona, Pradas Barriga, Irene, Berdún Hernández, Rebeca, Sanchez, Isabel, Naudí i Farré, Alba, Garí Marsol, Eloi, Barja, Gustavo, Pamplona Gras, Reinald   +8 more
openaire   +3 more sources

Insights from yeast into whether the rapamycin inhibition of heat shock transcription factor (Hsf1) can prevent the Hsf1 activation that results from treatment with an Hsp90 inhibitor [PDF]

, 2014
In human cells TORC1 mTOR (target of rapamycin) protein kinase complex renders heat shock transcription factor 1 (Hsf1) competent for stress activation. In such cells, as well as in yeast, the selective TORC1 inhibitor rapamycin blocks this activation in
Atkins, Baur, Baur, Blagosklonny, Broach, Calderwood, Corry, De Virgilio, Ellis, Gaber, Griffin, Hall, Hall, Hall, Hall, Hall, Heitman, Heitman, Lee, Lindquist, Loewith, Loewith, Macleod, Miller, Nagata, Nagata, Neckers, Partridge, Pavletich, Pearl, Piper, Piper, Piper, Porter, Powell, Powers, Prodromou, Proia, Sakurai, Sessa, Stoeltzing, Stoeltzing, Tan, Thiele, Thiele, Thiele, Thiele, Workman, Workman, Workman, Xing, Yonezawa   +51 more
core   +3 more sources

Dietary sodium sulphate supplementation during mid-to-late gestation improves placental angiogenesis, bile acid metabolism, and serum amino acid concentrations of sows

Animal
Sulphate plays a vital role in the growth and development of the foetus. Sodium sulphate (Na2SO4) is utilised as a dietary protein nutrient factor and helps replenish sulphur elements in livestock and poultry.
R. Zhou, L. Zhe, S.S. Lai, H.M. Wen, L. Hu, X.L. Zhang, Y. Zhuo, S.Y. Xu, Y. Lin, B. Feng, L.Q. Che, D. Wu, Z.F. Fang   +12 more
doaj   +1 more source

The sensitivity of mTORC1 signaling activation renders tissue regenerative capacity

Cell Regeneration, 2023
A better understanding of how and why the regenerative capacity differs among species will not only provide insights into the regeneration process but also hold value for the development of regenerative medicine and the improvement of healing procedures.
Hanyu Dou, Jianzhou Li, Taomin Huang, Xiaolei Ding   +3 more
doaj   +1 more source

Resolution of depression: Antidepressant actions of resolvins

Neuroscience Research
Major depressive disorder, one of the most widespread mental illnesses, brings about enormous individual and socioeconomic consequences. Conventional monoaminergic antidepressants require weeks to months to produce a therapeutic response, and ...
Satoshi Deyama, Katsuyuki Kaneda, Masabumi Minami   +2 more
doaj   +1 more source