Results 81 to 90 of about 47,262 (255)
Molecular & Cellular Oncology, 2019 Modeling renal cancer in the mouse has been challenging. We recently showed that upregulation of mechanistic target of rapamycin complex 1 (mTORC1) in a restricted segment of the renal tubule leads to downregulation of the tricarboxylic acid (TCA) cycle ...
Luca Drusian, Alessandra Boletta
doaj +1 more source
Targeting lipid signalling in cancer [PDF]
, 2010 Phosphoinositide 3-kinases (PI3Ks) play an important role in a variety of cellular activities, including mitogenic signalling and cell survival, cytoskeletal remodelling, metabolic control, proliferation and vesicular trafficking.
Cmiljanović, Vladimir
core +1 more source
FEBS Open Bio, EarlyView.UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová +2 more
wiley +1 more source
Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies
Frontiers in Neuroanatomy, 2021 Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a spectrum of neurodevelopmental disorders (termed mTORopathies) associated with malformation of
Lena H. Nguyen +3 more
doaj +1 more source
Chromosomal Instability Drives Glioblastoma Heterogeneity and Therapeutic Opportunities
Advanced Science, EarlyView.ABSTRACT Glioblastoma, the most aggressive and lethal form of brain cancer, is defined by profound genomic instability, with Chromosomal Instability (CIN) playing a central role in driving tumor progression, therapy resistance, and poor prognosis. CIN is characterized by numerical and structural alterations, is driven by mechanisms such as mitotic ...
Amarnath Pal +3 more
wiley +1 more source
Transplantation Reports, 2018 Chronic rejection of transplanted organs remains an unresolved issue in clinical organ transplantation. The macrophages play a crucial role in the development of chronic rejection.
Wei Chen +4 more
doaj +1 more source
Mechanistic Target of Rapamycin Complex 1 in Distal Convoluted Tubule and Renal Potassium Handling
Journal of the American Society of NephrologyKey Points Rapamycin inhibited Kir4.1/Kir5.1, decreased Na-Cl-cotransporter (NCC), and increased renal potassium (K + ) excretion.
Yu Xiao +4 more
openaire +2 more sources
, 2014 Mammalian target of rapamycin (mTOR), which is now referred to as mechanistic target of rapamycin, integrates many signals, including those from growth factors, energy status, stress, and amino acids, to regulate cell growth and proliferation, protein ...
Lili Bao +7 more
core +1 more source
Detection of Protein–Protein Interactions in Escherichia coli With Single Molecule Sensitivity
Advanced Science, EarlyView.This article describes a regulatory circuit in Escherichia coli able to detect protein–protein interactions with exquisite sensitivity. The interaction between two hybrid proteins fused to Bordetella pertussis adenylate cyclase and its activator calmodulin triggers a potent cyclic AMP signaling cascade.
Marilyne Davi, Daniel Ladant
wiley +1 more source
Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy
Autophagy Reports, 2023 Intracellular pathogens establish persistent infections by generating reservoirs that protect them from the action of antibiotics and the host immune response.
Mariana I. Capurro +3 more
doaj +1 more source