Results 101 to 110 of about 68,619 (285)

Convergent and Divergent Mechanisms of Epileptogenesis in mTORopathies

Frontiers in Neuroanatomy, 2021
Hyperactivation of the mechanistic target of rapamycin complex 1 (mTORC1) due to mutations in genes along the PI3K-mTOR pathway and the GATOR1 complex causes a spectrum of neurodevelopmental disorders (termed mTORopathies) associated with malformation of
Lena H. Nguyen, Lena H. Nguyen, Angélique Bordey, Angélique Bordey   +3 more
doaj   +1 more source

Repeated bouts of resistance exercise in rats alter mechanistic target of rapamycin complex 1 activity and ribosomal capacity but not muscle protein synthesis [PDF]

, 2021
Takaya Kotani, Junya Takegaki, Yuki Tamura, Karina Kouzaki, Koichi Nakazato, Naokata Ishii   +5 more
openalex   +1 more source

mTORC1 in the Paneth cell niche couples intestinal stem cell function to calorie intake [PDF]

, 2012
How adult tissue stem and niche cells respond to the nutritional state of an organism is not well understood. Here we find that Paneth cells, a key constituent of the mammalian intestinal stem-cell (ISC) niche, augment stem-cell function in response to ...
Abdulmetin Dursun, Atul K. Bhan, BD Simons, C Beard, CM McCay, D Nakada, DA Guertin, David M. Sabatini, DD Sarbassov, DE Cohen, DT Breault, Dudley W. Lamming, E Sangiorgi, G. Petur Nielsen, GG Altmann, HJ Snippert, J Chen, Khristian E. Bauer-Rowe, Kivanc Birsoy, L Bondolfi, L Zhu, Lawrence R. Zukerberg, LE O’Brien, LG van der Flier, M Podesta, Mari Mino-Kenudson, Martin Selig, N Barker, N Takeda, NY Kalaany, OH Yilmaz, OH Yilmaz, Pekka Katajisto, RP Ertl, S Dunel-Erb, S Hempenstall, S Sengupta, Shomit Sengupta, SR Spindler, T Sato, T Sato, V Marsh, V. Onur Yilmaz, Vikram Deshpande, Yetis Gültekin, Ömer H. Yilmaz   +45 more
core   +2 more sources

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]

, 2019
open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J., El-Seed, Hesham, Ismail, Amin, Lai, Shanshan, Liu, Dan, Wu, Desheng, Xiao, Jianbo, Zhao, Chao, Zou, Xiaobo   +8 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Coinhibition of mTORC1/mTORC2 and RhoA /ROCK pathways prevents chronic rejection of rat cardiac allografts

Transplantation Reports, 2018
Chronic rejection of transplanted organs remains an unresolved issue in clinical organ transplantation. The macrophages play a crucial role in the development of chronic rejection.
Wei Chen, Wenhao Chen, Xian C Li, Rafik M Ghobrial, Malgorzata Kloc   +4 more
doaj   +1 more source

Advances in autophagy regulatory mechanisms [PDF]

, 2016
Autophagy plays a critical role in cell metabolism by degrading and recycling internal components when challenged with limited nutrients. This fundamental and conserved mechanism is based on a membrane trafficking pathway in which nascent autophagosomes ...
Chan, Edmond Y. W., Gallagher, Laura E., Williamson, Leon E.   +2 more
core   +2 more sources

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Survival of intracellular pathogens in response to mTORC1- or TRPML1-TFEB-induced xenophagy

Autophagy Reports, 2023
Intracellular pathogens establish persistent infections by generating reservoirs that protect them from the action of antibiotics and the host immune response.
Mariana I. Capurro, Akriti Prashar, Xiaodong Gao, Nicola L. Jones   +3 more
doaj   +1 more source