Results 31 to 40 of about 47,262 (255)

Perspective: The Potential Role of Essential Amino Acids and the Mechanistic Target of Rapamycin Complex 1 (mTORC1) Pathway in the Pathogenesis of Child Stunting. [PDF]

Adv Nutr, 2016
Stunting is the best summary measure of chronic malnutrition in children. Approximately one-quarter of children under age 5 worldwide are stunted. Lipid-based or micronutrient supplementation has little to no impact in reducing stunting, which suggests that other critical dietary nutrients are missing.
Semba RD, Trehan I, Gonzalez-Freire M, Kraemer K, Moaddel R, Ordiz MI, Ferrucci L, Manary MJ.   +7 more
europepmc   +4 more sources

Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration. [PDF]

Hypertension, 2022
Shimada S, Yang C, Kumar V, Mattson DL, Cowley AW.   +4 more
europepmc   +2 more sources

Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. [PDF]

Proc Natl Acad Sci U S A, 2014
Significance The mechanistic or mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that integrates various environmental signals/cues to regulate cell growth, proliferation, metabolism, and survival. The promyelocytic leukemia zinc-finger transcription factor (PLZF) is known to be critical
Shin J, Wang S, Deng W, Wu J, Gao J, Zhong XP.   +5 more
europepmc   +4 more sources

Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. [PDF]

J Biol Chem, 2013
In this study, the interaction of mTORC1 with its downstream targets p70S6K1 and 4E-BP1 was evaluated in both mouse liver and mouse embryonic fibroblasts following combined disruption of the genes encoding 4E-BP1 and 4E-BP2. Phosphorylation of p70S6K1 was dramatically elevated in the livers of mice lacking 4E-BP1 and 4E-BP2 following feeding-induced ...
Dennis MD, Kimball SR, Jefferson LS.
europepmc   +4 more sources

Protocol for microinjection of rapamycin into the zebrafish habenula

STAR Protocols
Summary: Mechanistic target of rapamycin complex 1 (mTorC1) activity plays a crucial role in brain development. Here, we present an approach for rapamycin microinjection into the habenula of larval zebrafish to achieve localized inhibition of the mTorC1 ...
Olga Doszyn, Tomasz Dulski, Justyna Zmorzynska   +2 more
doaj   +2 more sources

Reactivation of cocaine contextual memory engages mechanistic target of rapamycin/S6 kinase 1 signaling

Frontiers in Pharmacology, 2022
Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen ...
Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald   +7 more
doaj   +1 more source

Mechanistic Target of Rapamycin Complex 1/S6 Kinase 1 Signals Influence T Cell Activation Independently of Ribosomal Protein S6 Phosphorylation. [PDF]

J Immunol, 2015
Ag-dependent activation of naive T cells induces dramatic changes in cellular metabolism that are essential for cell growth, division, and differentiation. In recent years, the serine/threonine kinase mechanistic target of rapamycin (mTOR) has emerged as
Salmond RJ, Brownlie RJ, Meyuhas O, Zamoyska R.   +3 more
europepmc   +2 more sources

Prenatal Mechanistic Target of Rapamycin Complex 1 (m TORC1) Inhibition by Rapamycin Treatment of Pregnant Mice Causes Intrauterine Growth Restriction and Alters Postnatal Cardiac Growth, Morphology, and Function. [PDF]

J Am Heart Assoc, 2017
BACKGROUND: Fetal growth impacts cardiovascular health throughout postnatal life in humans. Various animal models of intrauterine growth restriction exhibit reduced heart size at birth, which negatively influences cardiac function in adulthood.
Hennig M, Fiedler S, Jux C, Thierfelder L, Drenckhahn JD.   +4 more
europepmc   +2 more sources

Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop

Frontiers in Cell and Developmental Biology, 2021
In recent years, an increasing number of studies have reported that long noncoding RNAs (lncRNAs) play crucial roles in breast cancer (BC) progression and metastasis. Another study group of our research center reported that lncRNA HCG18 was one of the 30
Xu Liu, Kun Qiao, Kaiyuan Zhu, Xianglan Li, Chunbo Zhao, Jiaqi Li, Dawei Feng, Yu Fang, Peng Wang, Cheng Qian, Wenbo Qiao   +10 more
doaj   +1 more source

Inhibition of the mTORC1 pathway alleviates adipose tissue fibrosis

Heliyon, 2023
Background: Adipose fibrosis is a major factor of adipose dysfunction, which causes metabolic dysfunction during obesity, but its molecular mechanisms are poorly understood.
Sa Gong, Chang Li, Qingyang Leng, Chongxiao Liu, Yi Zhu, Hongli Zhang, Xiaohua Li   +6 more
doaj   +1 more source