Results 31 to 40 of about 48,916 (224)

Acute Increase of Renal Perfusion Pressure Causes Rapid Activation of mTORC1 (Mechanistic Target Of Rapamycin Complex 1) and Leukocyte Infiltration. [PDF]

Hypertension, 2022
Shimada S, Yang C, Kumar V, Mattson DL, Cowley AW.   +4 more
europepmc   +2 more sources

Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins. [PDF]

BMC Dev Biol, 2014
The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that many signaling pathways, including Activin, Bmp, Fgf, sonic hedgehog, Insulin-like growth factor (IGF), Notch, retinoic acid, and Wnt, are ...
Hirose K, Shiomi T, Hozumi S, Kikuchi Y.
europepmc   +6 more sources

Loss of the Mechanistic Target of Rapamycin Complex 1 Causes a Lethal Alpha-1 Antitrypsin Deficiency-Associated Liver Disease. [PDF]

Cell Mol Gastroenterol Hepatol
Bewersdorf L, Haber S, Volkert I, Remih K, Gross A, Preisinger C, Kroll L, Cramer T, Gaisa NT, Leypold S, Rolle-Kampczyk U, Brunetti-Pierri N, von Bergen M, Rosenberger F, Weiss C, Guldiken N, Strnad P.   +16 more
europepmc   +2 more sources

Reactivation of cocaine contextual memory engages mechanistic target of rapamycin/S6 kinase 1 signaling

Frontiers in Pharmacology, 2022
Mechanistic target of rapamycin (mTOR) C1 and its downstream effectors have been implicated in synaptic plasticity and memory. Our prior work demonstrated that reactivation of cocaine memory engages a signaling pathway consisting of Akt, glycogen ...
Xiangdang Shi, Eva von Weltin, Emma Fitzsimmons, Chau Do, Carolina Caban Rivera, Chongguang Chen, Lee-Yuan Liu-Chen, Ellen M. Unterwald   +7 more
doaj   +1 more source

Long Noncoding RNA HCG18 Promotes Malignant Phenotypes of Breast Cancer Cells via the HCG18/miR-103a-3p/UBE2O/mTORC1/HIF-1α–Positive Feedback Loop

Frontiers in Cell and Developmental Biology, 2021
In recent years, an increasing number of studies have reported that long noncoding RNAs (lncRNAs) play crucial roles in breast cancer (BC) progression and metastasis. Another study group of our research center reported that lncRNA HCG18 was one of the 30
Xu Liu, Kun Qiao, Kaiyuan Zhu, Xianglan Li, Chunbo Zhao, Jiaqi Li, Dawei Feng, Yu Fang, Peng Wang, Cheng Qian, Wenbo Qiao   +10 more
doaj   +1 more source

Inhibition of the mTORC1 pathway alleviates adipose tissue fibrosis

Heliyon, 2023
Background: Adipose fibrosis is a major factor of adipose dysfunction, which causes metabolic dysfunction during obesity, but its molecular mechanisms are poorly understood.
Sa Gong, Chang Li, Qingyang Leng, Chongxiao Liu, Yi Zhu, Hongli Zhang, Xiaohua Li   +6 more
doaj   +1 more source

Progranulin depletion inhibits proliferation via the transforming growth factor beta/SMAD family member 2 signaling axis in Kasumi-1 cells

Heliyon, 2021
Progranulin is an autocrine growth factor that promotes proliferation, migration, invasion, and chemoresistance of various cancer cells. These mechanisms mainly depend on the protein kinase B (Akt)/mechanistic target of rapamycin (mTOR) pathway.
Kuniaki Yabe, Yasuko Yamamoto, Masao Takemura, Takeshi Hara, Hisashi Tsurumi, Ginette Serrero, Toshitaka Nabeshima, Kuniaki Saito   +7 more
doaj   +1 more source

The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back

Frontiers in Cell and Developmental Biology, 2021
The tuberous sclerosis protein complex (TSC complex) is a key integrator of metabolic signals and cellular stress. In response to nutrient shortage and stresses, the TSC complex inhibits the mechanistic target of rapamycin complex 1 (mTORC1) at the ...
Ulrike Rehbein, Mirja Tamara Prentzell, Mirja Tamara Prentzell, Marti Cadena Sandoval, Marti Cadena Sandoval, Alexander Martin Heberle, Alexander Martin Heberle, Elizabeth P. Henske, Christiane A. Opitz, Christiane A. Opitz, Kathrin Thedieck, Kathrin Thedieck, Kathrin Thedieck   +12 more
doaj   +1 more source

Arterial wall fibrosis in Takayasu arteritis and its potential for therapeutic modulation

Frontiers in Immunology, 2023
Arterial wall damage in Takayasu arteritis (TAK) can progress despite immunosuppressive therapy. Vascular fibrosis is more prominent in TAK than in giant cell arteritis (GCA).
Durga Prasanna Misra, Kritika Singh, Aman Sharma, Vikas Agarwal   +3 more
doaj   +1 more source

The amino acid transporter SLC36A4 regulates the amino acid pool in retinal pigmented epithelial cells and mediates the mechanistic target of rapamycin, complex 1 signaling. [PDF]

Aging Cell, 2017
Shang P, Valapala M, Grebe R, Hose S, Ghosh S, Bhutto IA, Handa JT, Lutty GA, Lu L, Wan J, Qian J, Sergeev Y, Puertollano R, Zigler JS, Xu GT, Sinha D.   +15 more
europepmc   +2 more sources