Pulsatile Leucine Administration during Continuous Enteral Feeding Enhances Skeletal Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis in a Preterm Piglet Model. [PDF]
J Nutr, 2023 Rudar M +8 more
europepmc +2 more sources
Tuberous Sclerosis Complex 1–Mechanistic Target of Rapamycin Complex 1 Signaling Determines Brown-to-White Adipocyte Phenotypic Switch [PDF]
Diabetes, 2014 Interconversion of white and brown adipocytes occurs between anabolic and catabolic states. The molecular mechanism regulating this phenotypic switch remains largely unknown. This study explores the role of tuberous sclerosis complex 1 (TSC1)–mechanistic target of rapamycin (mTOR) signaling in the conversion of brown to white adipose tissue (WAT).
Xinxin Xiang +7 more
openalex +3 more sources
Oncogenic mutations in adenomatous polyposis coli (Apc) activate mechanistic target of rapamycin complex 1 (mTORC1) in mice and zebrafish [PDF]
Disease Models & Mechanisms, 2014 Truncating mutations in adenomatous polyposis coli (APC) are strongly linked to colorectal cancers. APC is a negative regulator of the Wnt pathway and constitutive Wnt activation mediated by enhanced Wnt–β-catenin target gene activation is believed to be
Alexander J. Valvezan +4 more
doaj +3 more sources
Mechanistic target of rapamycin complex 1 signaling regulates cell proliferation, cell survival, and differentiation in regenerating zebrafish fins. [PDF]
BMC Dev Biol, 2014 The mechanistic target of rapamycin complex1 (mTORC1) signaling pathway has been implicated in functions of multicellular processes, including cell growth and metabolism. Although recent reports showed that many signaling pathways, including Activin, Bmp, Fgf, sonic hedgehog, Insulin-like growth factor (IGF), Notch, retinoic acid, and Wnt, are ...
Hirose K, Shiomi T, Hozumi S, Kikuchi Y.
europepmc +6 more sources
Activation of mechanistic target of rapamycin complex 1: the common link between rheumatoid arthritis and diabetes mellitus [PDF]
Rheumatology, 2018 Valerio De Vita, Bodo C. Melnik
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Mechanistic target of rapamycin complex 1 is critical for invariant natural killer T-cell development and effector function. [PDF]
Proc Natl Acad Sci U S A, 2014 Significance The mechanistic or mammalian target of rapamycin (mTOR) is an evolutionarily conserved serine/threonine kinase that integrates various environmental signals/cues to regulate cell growth, proliferation, metabolism, and survival. The promyelocytic leukemia zinc-finger transcription factor (PLZF) is known to be critical
Shin J +5 more
europepmc +4 more sources
The mechanistic target of rapamycin complex 1 critically regulates the function of mononuclear phagocytes and promotes cardiac remodeling in acute ischemia. [PDF]
J Mol Cell Cardiol, 2021 Chen G, Phan V, Luo X, Cao DJ.
europepmc +3 more sources
Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. [PDF]
J Biol Chem, 2013 In this study, the interaction of mTORC1 with its downstream targets p70S6K1 and 4E-BP1 was evaluated in both mouse liver and mouse embryonic fibroblasts following combined disruption of the genes encoding 4E-BP1 and 4E-BP2. Phosphorylation of p70S6K1 was dramatically elevated in the livers of mice lacking 4E-BP1 and 4E-BP2 following feeding-induced ...
Dennis MD, Kimball SR, Jefferson LS.
europepmc +4 more sources
Activated Protein Phosphatase 2A Disrupts Nutrient Sensing Balance Between Mechanistic Target of Rapamycin Complex 1 and Adenosine Monophosphate-Activated Protein Kinase, Causing Sarcopenia in Alcohol-Associated Liver Disease. [PDF]
Hepatology, 2021 Davuluri G +15 more
europepmc +3 more sources
IQ Domain-Containing GTPase-Activating Protein 1 Regulates Cytoskeletal Reorganization and Facilitates NKG2D-Mediated Mechanistic Target of Rapamycin Complex 1 Activation and Cytokine Gene Translation in Natural Killer Cells. [PDF]
Front Immunol, 2018 Abel AM +8 more
europepmc +2 more sources