Metabolomic and Lipidomic Signature of Skeletal Muscle with Constitutively Active Mechanistic Target of Rapamycin Complex 1. [PDF]
J Nutr, 2023 Regulation of mechanistic target of rapamycin complex 1 (mTORC1) plays an important role in aging and nutrition. For example, caloric restriction reduces mTORC1 signaling and extends lifespan, whereas nutrient abundance and obesity increase mTORC1 signaling and reduce lifespan.
Maroto R +5 more
europepmc +3 more sources
Effect of mechanistic/mammalian target of rapamycin complex 1 on mitochondrial dynamics during skeletal muscle hypertrophy [PDF]
Physiological Reports, 2021 Mechanistic/mammalian target of rapamycin (mTOR) is a central factor of protein synthesis signaling and plays an important role in the resistance training‐induced increase in skeletal muscle mass and subsequent skeletal muscle hypertrophy response.
Kazuki Uemichi +3 more
doaj +3 more sources
mTORC1 (Mechanistic Target of Rapamycin Complex 1) Signaling in Endothelial and Smooth Muscle Cells Is Required for Vascular Function. [PDF]
Hypertension, 2021 mTORC1 (Mechanistic target of rapamycin complex 1) serves as a molecular hub and intracellular energy sensor that regulate various cellular processes. Emerging evidence points to mTORC1 signaling as a critical regulator of cardiovascular function with implications for cardiovascular disease.
Reho JJ +4 more
europepmc +4 more sources
Mechanistic Target of Rapamycin Complex 1 Signaling Links Hypoxia to Increased IGFBP-1 Phosphorylation in Primary Human Decidualized Endometrial Stromal Cells [PDF]
Biomolecules, 2021 Insulin-like growth factor-1 (IGF-1) bioavailability in pregnancy is governed by IGF binding protein (IGFBP-1) and its phosphorylation, which enhances the affinity of IGFBP-1 for the growth factor.
Pinki Nandi +5 more
doaj +2 more sources
Mechanistic Target of Rapamycin Complex 1 in Distal Convoluted Tubule and Renal Potassium Handling. [PDF]
J Am Soc NephrolKey Points Rapamycin inhibited Kir4.1/Kir5.1, decreased Na-Cl-cotransporter (NCC), and increased renal potassium (K + ) excretion.
Xiao Y +4 more
europepmc +3 more sources
Mechanistic target of rapamycin complex 1 and 2 in human temporal lobe epilepsy. [PDF]
Ann Neurol, 2018 ObjectiveTemporal lobe epilepsy (TLE) is a chronic epilepsy syndrome defined by seizures and progressive neurological disabilities, including cognitive impairments, anxiety, and depression. Here, human TLE specimens were investigated focusing on the mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) and complex 2 (mTORC2) activities in the brain,
Talos DM +9 more
europepmc +4 more sources
Labor inhibits placental mechanistic target of rapamycin complex 1 signaling. [PDF]
Placenta, 2014 Labor induces a myriad of changes in placental gene expression. These changes may represent a physiological adaptation inhibiting placental cellular processes associated with a high demand for oxygen and energy (e.g., protein synthesis and active transport) thereby promoting oxygen and glucose transfer to the fetus.
Lager S +5 more
europepmc +4 more sources
Regulation of protein kinase Cδ Nuclear Import and Apoptosis by Mechanistic Target of Rapamycin Complex-1. [PDF]
Sci Rep, 2019 Abstract Inactivation of the protein complex ‘mechanistic target of rapamycin complex 1’ (mTORC1) can increase the nuclear content of transcriptional regulators of metabolism and apoptosis. Previous studies established that nuclear import of signal transducer and activator of transcription-1 (STAT1) requires the mTORC1-associated ...
Layoun A +15 more
europepmc +5 more sources
Environmental signaling through the mechanistic target of rapamycin complex 1: mTORC1 goes nuclear. [PDF]
Cell Cycle, 2014 Mechanistic target of rapamycin complex 1 (mTORC1) is a well-known regulator of cell growth and proliferation in response to environmental stimuli and stressors. To date, the majority of mTORC1 studies have focused on its function as a cytoplasmic effector of translation regulation.
Workman JJ, Chen H, Laribee RN.
europepmc +4 more sources
Cachexia Disrupts Diurnal Regulation of Activity, Feeding, and Muscle Mechanistic Target of Rapamycin Complex 1 in Mice. [PDF]
Med Sci Sports Exerc, 2020 ABSTRACT Introduction Cancer cachexia is characterized by severe skeletal muscle mass loss, which is driven by decreased muscle protein synthesis and increased protein degradation. Daily physical activity and feeding behaviors exhibit diurnal fluctuations in mice that can impact the systemic environment and skeletal ...
Counts BR +5 more
europepmc +5 more sources