Results 11 to 20 of about 18,502 (170)

Blocking the Farnesyl Pocket of PDEδ Reduces Rheb-Dependent mTORC1 Activation and Survival of Tsc2-Null Cells

Frontiers in Pharmacology, 2022
Rheb is a small GTPase member of the Ras superfamily and an activator of mTORC1, a protein complex master regulator of cell metabolism, growth, and proliferation. Rheb/mTORC1 pathway is hyperactivated in proliferative diseases, such as Tuberous Sclerosis
Marisol Estrella Armijo, Marisol Estrella Armijo, Emilia Escalona, Daniela Peña, Alejandro Farias, Violeta Morin, Matthias Baumann, Bert Matthias Klebl, Roxana Pincheira, Ariel Fernando Castro   +9 more
doaj   +1 more source

p38 regulates the tumor suppressor PDCD4 via the TSC-mTORC1 pathway

Cell Stress, 2021
Programmed cell death protein 4 (PDCD4) exerts critical functions as tumor suppressor and in immune cells to regulate inflammatory pro-cesses. The phosphoinositide 3-kinase (PI3K) promotes degradation of PDCD4 via mammalian target of rapamycin complex 1 (
Clarissa Braun, Karl Katholnig, Christopher Kaltenecker, Monika Linke, Nyamdelger Sukhbaatar, Markus Hengstschläger, Thomas Weichhart   +6 more
doaj   +1 more source

Lost in translation: a neglected mTOR target for lymphangioleiomyomatosis

European Respiratory Review, 2023
Lymphangioleiomyomatosis (LAM) is a cystic lung disease of women resulting from mutations in tuberous sclerosis complex (TSC) genes that suppress the mammalian target of rapamycin complex 1 (mTORC1) pathway.
Jilly F. Evans, Francis X. McCormack, Nahum Sonenberg, Vera P. Krymskaya   +3 more
doaj   +1 more source

Reversal of memory and autism-related phenotypes in Tsc2+/− mice via inhibition of Nlgn1

Frontiers in Cell and Developmental Biology, 2023
Tuberous sclerosis complex (TSC) is a rare monogenic disorder co-diagnosed with high rates of autism and is caused by loss of function mutations in the TSC1 or TSC2 genes.
Kleanthi Chalkiadaki, Kleanthi Chalkiadaki, Elpida Statoulla, Maria Zafeiri, Nabila Haji, Jean-Claude Lacaille, Craig M. Powell, Seyed Mehdi Jafarnejad, Arkady Khoutorsky, Christos G. Gkogkas   +9 more
doaj   +1 more source

Regulation of mTORC1 by amino acids in mammalian cells: A general picture of recent advances

Animal Nutrition, 2021
The mechanistic target of rapamycin complex 1 (mTORC1) integrates various types of signal inputs, such as energy, growth factors, and amino acids to regulate cell growth and proliferation mainly through the 2 direct downstream targets, eukaryotic ...
Shizhe Zhang, Xueyan Lin, Qiuling Hou, Zhiyong Hu, Yun Wang, Zhonghua Wang   +5 more
doaj   +1 more source

Adipocyte-Specific Inhibition of Mir221/222 Ameliorates Diet-Induced Obesity Through Targeting Ddit4

Frontiers in Endocrinology, 2022
MicroRNAs expressed in adipocytes are involved in transcriptional regulation of target mRNAs in obesity, but miRNAs critically involved in this process is not well characterized.
Satoshi Yamaguchi, Dongxiao Zhang, Akihiro Katayama, Naoko Kurooka, Ryosuke Sugawara, Haya Hamed Hassan Albuayjan, Atsuko Nakatsuka, Jun Eguchi, Jun Wada   +8 more
doaj   +1 more source

Metformin Modulates T Cell Function and Alleviates Liver Injury Through Bioenergetic Regulation in Viral Hepatitis

Frontiers in Immunology, 2021
Metformin is not only the first-line medication for the treatment of type 2 diabetes, but it is also effective as an anti-inflammatory, anti-oxidative and anti-tumor agent. However, the effect of metformin during viral hepatitis remains elusive. Using an
Lanman Xu, Lanman Xu, Xiaofang Wang, Xiaofang Wang, Yan Chen, Lynn Soong, Lynn Soong, Lynn Soong, Yongping Chen, Jiyang Cai, Yuejin Liang, Yuejin Liang, Jiaren Sun, Jiaren Sun, Jiaren Sun   +14 more
doaj   +1 more source

Screen for chemical modulators of autophagy reveals novel therapeutic inhibitors of mTORC1 signaling. [PDF]

PLoS ONE, 2009
BACKGROUND:Mammalian target of rapamycin complex 1 (mTORC1) is a protein kinase that relays nutrient availability signals to control numerous cellular functions including autophagy, a process of cellular self-eating activated by nutrient depletion ...
Aruna D Balgi, Bruno D Fonseca, Elizabeth Donohue, Trevor C F Tsang, Patrick Lajoie, Christopher G Proud, Ivan R Nabi, Michel Roberge   +7 more
doaj   +1 more source

ETV2 regulates PARP-1 binding protein to induce ER stress–mediated death in tuberin-deficient cells

Life Science Alliance, 2022
In tuberin-deficient cells, SYK regulates ETV2 nuclear translocation, where it regulated Parpbp expression. Silencing Etv2 or Parpbp induces ER stress–mediated cell death in tuberin-deficient cells.
Shikshya Shrestha, Anthony Lamattina, Gustavo Pacheco-Rodriguez, Julie Ng, Xiaoli Liu, Abhijeet Sonawane, Jewel Imani, Weiliang Qiu, Kosmas Kosmas, Pierce Louis, Anne Hentschel, Wendy K Steagall, Rieko Onishi, Helen Christou, Elizabeth P Henske, Kimberly Glass, Mark A Perrella, Joel Moss, Kelan Tantisira, Souheil El-Chemaly   +19 more
doaj   +1 more source

NFATc2-dependent epigenetic downregulation of the TSC2/Beclin-1 pathway is involved in neuropathic pain induced by oxaliplatin

Molecular Pain, 2023
Neuropathic pain is a common dose-limiting side effect of oxaliplatin, which hampers the effective treatment of tumors. Here, we found that upregulation of transcription factor NFATc2 decreased the expression of Beclin-1, a critical molecule in autophagy,
Meng Liu, Jing-Wen Mai, De-Xing Luo, Guan-Xi Liu, Ting Xu, Wen-Jun Xin, Su-Yan Lin, Zhen-Yu Li   +7 more
doaj   +1 more source