Results 91 to 100 of about 5,403,298 (185)

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Predictive Power of EEG in Infants with Tuberous Sclerosis

Pediatric Neurology Briefs, 2016
Investigators from University of California- Los Angeles and collaborators from across the country report on the use of prospective EEGs in infants with tuberous sclerosis complex (TSC) to predict evolution to seizures.
Molly Tracy
doaj   +1 more source

In vivo gene therapy with plasmid DNA-tuberous sclerosis complex-2 (TSC-2) in an oral squamous cell carcinoma. [PDF]

, 2005
Supriatno - Terapi gen menggunakan plasmid DNA-Tuberous sclerosis complex-2 (TSC-2) pada sel skuamos karsinoma rongga mulut in vivo Latar belakang: Tuberous sclerosis complex (TSC), suatu sindrom bawaan yang mempengaruhi individu terhadap tingginya ...
Supriatmo
core   +2 more sources

Natural Products Exhibit Therapeutic Potential in Treating Rheumatoid Arthritis by Targeting the PI3K/Akt Signaling Pathway

Phytotherapy Research, EarlyView.
This review summarizes how natural products, mainly including flavonoids, terpenoids, alkaloids, and polyphenols alleviate RA via PI3K/Akt pathway, regulating inflammation, proliferation, apoptosis, angiogenesis, and osteoclast differentiation. The figure was created by Figdraw (https://www.figdraw.com/#/).
Haishuo Ren, Yige Wang, Wenjing Ma, Omachi Daniel Ogaji, Shujing Chen, Kunze Du, Xuemi Zhang, Bo Xu, Shanxing Zhai, Shiming Fang, Yanxu Chang   +10 more
wiley   +1 more source

Oral lesions in tuberous sclerosis

Journal of Indian Academy of Oral Medicine and Radiology, 2018
Tuberous sclerosis complex (TSC) is an autosomal-dominant neurocutaneous syndrome with an approximate incidence of 1 in 10,000–50,000. The cardinal features of TSC are skin lesions, convulsive seizures, and mental retardation.
Lakshmi S Reddy, Tulika Singh, Vinod K Reddy, Sachin Mittal   +3 more
doaj   +1 more source

Mapping the Tissue Architecture and Endothelial‐PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics

Cancer Science, EarlyView.
Spatial multi‐omics mapping of hepatic angiomyolipoma reveals that PEComas tightly co‐localize with endothelial cells, which drive autophagic flux in adjacent tumor cells via a paracrine PDGFD–PDGFRB–Ras axis, establishing a compensatory survival network that operates in parallel to canonical TSC–mTOR defects.
Xinyang Liu, Yang Guo, Xuehong Tie, Yu Liu, Fuyu Li, Jingkai Liu, Xiaohang Sun, Jiajun Zhao, Feng Geng, Yingjian Liang   +9 more
wiley   +1 more source

Tuberous Sclerosis Complex Presenting as Periungual Fibromas: A Rare Case Report and Literature Review [PDF]

Ying Li,1,* Zhipeng Wang,1,* Yanhua Yang,2 Xiaoyan Xu3 1Department of Pathology, Sanya Central Hospital (The Third People’s Hospital of Hainan Province), Sanya, 572000, People’s Republic of China; 2Department of Pathology, Qingdao Municipal ...
Li Y, Yang Y, Xu X, Wang Z
core  

Everolimus in the treatment of subependymal giant cell astrocytomas, angiomyolipomas, and pulmonary and skin lesions associated with tuberous sclerosis complex

Biologics: Targets & Therapy, 2013
David Neal Franz Department of Pediatrics, Tuberous Sclerosis Clinic, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA Abstract: Tuberous sclerosis complex (TSC) is an autosomal dominant genetic disorder caused by inactivating ...
Franz DN
doaj  

Neuropsychiatric manifestations of tuberous sclerosis in a young man in a psychiatric hospital in Botswana: a case report

Journal of International Medical Research
Tuberous sclerosis complex (TSC), first described in 1880, is a disorder that affects multiple systems. Its symptoms include seizures, intellectual disability, and angiofibromas.
Wame T. Chabalala, Kagiso Bojosi, Tseleng Maphane, Anthony A. Olashore   +3 more
doaj   +1 more source

Risk Factors for Autism in Tuberous Sclerosis

Pediatric Neurology Briefs, 2011
The prevalence and risk factors for autism spectrum disorders (ASD) in a cohort of 103 patients with tuberous sclerosis complex (TSC) were determined in a study at the Massachusetts General Hospital, Boston, MA.
J Gordon Millichap
doaj   +1 more source