Results 91 to 100 of about 1,958,086 (308)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Die Vorhaben der neuen Regierungen in Sachsen und Thüringen

, 2014
Sowohl in Sachsen als auch in Thüringen sind neue Regierungen ins Amt gekommen. Der Beitrag dokumentiert die in den Koalitionsverträgen formulierten Hauptvorhaben und deren zu erwartende Kosten und diskutiert, inwieweit sich Politikwechsel vollzogen ...
Lorenz, Luisa, Potrafke, Niklas, Tubes, Julia   +2 more
core  

Fluid insulation to prevent ice formation in heat exchangers [PDF]

, 1973
Heat transfer surfaces were insulated to maintain air side surface temperature above freezing. Double wall tubes, with annular space between tubes, were filled with static liquid hydrogen.
Coffinberry, G. A.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Phosphorus Equilibrium Between Liquid Iron and CaO-SiO₂-MgO-Al₂O₃-FeO-P₂O₅ Slags: EAF Slags, the Effect of Alumina and New Correlation

Metals, 2019
The increased use of electric arc furnace (EAF) steelmaking using up to 100% direct reduced iron (DRI) has prompted an interest in better control of phosphorus since iron ore and, consequently, DRI have higher phosphorus and silica compared to scrap ...
Andre N. Assis, Mohammed A. Tayeb, Seetharaman Sridhar, Richard J. Fruehan   +3 more
doaj   +1 more source

Tubular sublimatory evaporator heat sink [PDF]

, 1977
An evaporative refrigerator or cooler comprising a bundle of spaced, porous walled tubes closed at one of their ends and vented to a vacuum at the other end is disclosed.
Webbon, B. W.
core   +1 more source

Qualification Tests of the R11410-21 Photomultiplier Tubes for the XENON1T Detector

, 2017
The Hamamatsu R11410-21 photomultiplier tube is the photodetector of choice for the XENON1T dual-phase time projection chamber. The device has been optimized for a very low intrinsic radioactivity, a high quantum efficiency and a high sensitivity to ...
Barrow, P., Baudis, L., Cichon, D., Danisch, M., Franco, D., Kaether, F., Kish, A., Lindner, M., Mayani, D., Rauch, L., Undagoitia, T. Marrodan, Wei, Y., Wulf, J.   +12 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

On Detonability Limits of Gas Detonation in Tubes

Механика машин, механизмов и материалов, 2007
The near-limit propagation of spinning detonations in 3.5% C2H2+26.5% O2+70% Ar mixture have been carefully studied in tubes of 25.3 and 50 mm in diameters. Quantitative criteria governing the limits of stable, unstable, and low-velocity detonations have
O.G. Penyazkov
doaj