Results 81 to 90 of about 1,087,479 (281)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
On Detonability Limits of Gas Detonation in Tubes
Механика машин, механизмов и материалов, 2007 The near-limit propagation of spinning detonations in 3.5% C2H2+26.5% O2+70% Ar mixture have been carefully studied in tubes of 25.3 and 50 mm in diameters. Quantitative criteria governing the limits of stable, unstable, and low-velocity detonations have
O.G. Penyazkov
doaj
Molecular Oncology, EarlyView.Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach +9 more
wiley +1 more source
Chloride fluxes in lily pollen tubes: a critical reevaluation
, 2004 Microelectrodes, made from a Cl?-selective liquid ion exchanger previously used to measure putative Cl- fluxes in Lilium longiflorum pollen tubes, were characterized. The electrodes were poorly selective, possessing only about 10-fold selectivity for Cl?
Mark A. Messerli +7 more
core +1 more source
R134a flow boiling heat transfer in small diameter tubes [PDF]
, 2007 Copyright @ 2007 RT Edwards Inc.Boiling heat transfer in small diameter tubes has been experimentally investigated using R134a as the working fluid. The heat transfer periments were conducted with two stainless steel tubes of internal diameter 4.26 mm ...
Huo, Y, Karayiannis, TG, Tian, S
core +3 more sources
MONITORING LINES AND TUBES ON CHEST RADIOGRAPH IN THE CARDIAC INTENSIVE CARE UNIT
Journal of University Medical & Dental College, 2016 : A variety of medical devices are used in the intensive care unit for long durations. Each one of them is a double-edged sword: intended to save life, but life-threatening if in the wrong place.
Muhammad Jamil Akhtar +2 more
doaj
Metals, 2019 The increased use of electric arc furnace (EAF) steelmaking using up to 100% direct reduced iron (DRI) has prompted an interest in better control of phosphorus since iron ore and, consequently, DRI have higher phosphorus and silica compared to scrap ...
Andre N. Assis +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source