Results 181 to 190 of about 109,157 (295)

Predicting OCT2/MATEs‐Mediated Drug Interactions in Healthy Volunteers and Patients with Chronic Kidney Disease: Insights from Extended Clearance Concept, Endogenous Biomarkers, and In Vitro Inhibition Studies (Perspectives from the International Transporter Consortium)

Clinical Pharmacology &Therapeutics, EarlyView.
Organic cation transporter (OCT) 2 and multidrug and toxin extrusion (MATE) transporters play significant roles in the renal secretion of organic cations and drug–drug interactions (DDIs). Recent in vitro studies indicate that the Ki values for OCT2 exhibit substrate dependency and increase in potency with pre‐incubation.
Satoshi Asano, Aleksandra Galetin, Yoshiko Tomita, Kathleen M. Giacomini, Xiaoyan Chu, Xinning Yang, Toshimichi Nakamura, Hiroyuki Kusuhara, Yuichi Sugiyama   +8 more
wiley   +1 more source

ScGOclust: leveraging gene ontology to find functionally analogous cell types between distant species. [PDF]

Bioinformatics
Song Y, Hu Y, Dow J, Perrimon N, Papatheodorou I.   +4 more
europepmc   +1 more source

Ciliary Fine-structure of Epithelium of the Renal Tubule in Urodele, <i>Triturus ensicauda</i>, with Special Reference to the So-called ‘Dense Granules’ in the Basal Body

, 1964
Toyoaki Fujimoto
openalex   +2 more sources

Urea in the Seminiferous Tubule: Evidence for Active Transport [PDF]

, 1979
Terry T. Turner, Paul K. Hartmann, Stuart S. Howards   +2 more
openalex   +1 more source

Population Pharmacokinetic/Toxicodynamic Model for Polymyxin B in Critically Ill Patients to Identify the Risk of Nephrotoxicity

Clinical Pharmacology &Therapeutics, EarlyView.
Polymyxins are used against highly resistant Gram‐negative pathogens, and nephrotoxicity (acute kidney injury, AKI) is the major dose‐limiting adverse effect. We aimed to develop a well‐informed population pharmacokinetic/toxicodynamic (PK/TD) model using the largest polymyxin B‐treated critically ill patient population studied to inform polymyxin B ...
Patrick O. Hanafin, Ramya Mahadevan, Gauri G. Rao, Alexandre P. Zavascki, Ana Maria Sandri, Andrea Kwa, Marc H. Scheetz, Christine J. Kubin, Jayesh Shah, Benjamin P.Z. Cherng, Michael T. Yin, Jiping Wang, Lu Wang, David P. Calfee, Maureen Bolon, Anthony W. Purcell, Roger L. Nation, Jason M. Pogue, Jian Li, Keith S. Kaye   +19 more
wiley   +1 more source

GDNF enhances HGF-induced tubulogenesis and organization of Sertoli cell. [PDF]

J Assist Reprod Genet
Durkut-Kuzu B, Celik-Ozenci C.
europepmc   +1 more source

A TECHNIQUE FOR THE RADIOAUTOGRAPHY OF GERM CELLS IN WHOLE MOUNTS OF SEMINIFEROUS TUBULES

, 1969
Claire Huckins, Beatrix Markus Kopriwa
openalex   +1 more source

Sex cord tumor with annular tubules a distinctive ovarian tumor of the Peutz-Jeghers syndrome [PDF]

, 1970
Robert E. Scully
openalex   +1 more source

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Induction of proximal tubular proliferation and lengthening in response to sodium glucose linked cotransporter-2 inhibition in experimental rats. [PDF]

J Diabetes Investig
Wu E, Macklin S, Zhang Y, Thai K, Nghiem L, Di Ciano-Oliveira C, Coelho N, Wang H, Advani SL, Desjardins JF, Yuen DA, Misra P, Connelly KA, Nyengaard JR, Gilbert RE.   +14 more
europepmc   +1 more source