Results 201 to 210 of about 122,654 (313)

Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet. [PDF]

EMBO J
He HK, Kubo S, Chen X, Lv QH, Kage A, Ichikawa M.   +5 more
europepmc   +1 more source

Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka, Michael Lawton, Tom Chu, Gary S. Friedman, Katrina Peron, Stefan R. Sultana, Warren E. Glaab, Nicholas M. P. King   +7 more
wiley   +1 more source

Dentinal tubule penetration of AH Plus, MTA Fillapex, and BioRoot flow: a confocal laser scanning microscopy study. [PDF]

BMC Oral Health
Tosun S, Karataşlıoğlu E, Çulha E, Çetinkaya OB, Uzun İ.   +4 more
europepmc   +1 more source

Ontogeny of RSPO1, FOXL2, and RUNX1 during ovarian differentiation in the marsupial tammar wallaby

Developmental Dynamics, EarlyView.
Abstract Background RSPO1 and FOXL2 are female sex‐determining genes involved in the differentiation and organization of the ovary in some eutherian mammals. Mutations or loss of function of these genes are associated with partial to full sex reversal in mice, humans, and goats.
Monika R. Paranjpe, Yu Chen, Geoff Shaw, Marilyn B. Renfree   +3 more
wiley   +1 more source

Effect of calcium oxalate microcrystals on kidney proximal tubule epithelial cell gene expression in microgravity. [PDF]

NPJ Microgravity
Jones-Isaac K, Yeung CK, Bain J, Lidberg K, Yang J, Wang L, MacDonald J, Bammler T, Thummel KE, Corn M, Ruiz MV, Countryman S, Koenig P, Mann HH, Himmelfarb J, Kelly EJ.   +15 more
europepmc   +1 more source

Streptozotocin induced hyperglycemia in the axolotl

Developmental Dynamics, EarlyView.
Abstract Background Diabetes is a group of diseases characterized by loss of β cell mass and/or function, resulting in hyperglycemia. With no established curative treatment, this has initiated research in β cell regeneration. Current animal models have either limited regenerative capacity (mice) or small size and evolutionary distance from humans ...
Pernille Lajer Sørensen, Anita Dittrich, Henrik Lauridsen   +2 more
wiley   +1 more source

Sequence-encoded tubular architectures in disordered spider silk proteins revealed by multiscale simulations and NMR. [PDF]

PNAS Nexus
Forman CJ, Onofrei D, Stengel D, Aldana JE, Paolini C, Gianneschi NC, Holland GP.   +6 more
europepmc   +1 more source

Seminiferous Tubule [PDF]

, 2020
openaire   +1 more source

Characterization of THY1 Positive Proximal Tubule Cells in the Kidney Using Integrative Multiomics Spatial Analysis

Mahla Asghari
openalex   +1 more source

Meta‐analysis of sotagliflozin, a dual sodium‐glucose‐cotransporter 1/2 inhibitor, for heart failure in type 2 diabetes

ESC Heart Failure, Volume 12, Issue 2, Page 968-979, April 2025.
Abstract Sodium‐glucose co‐transporters (SGLTs) mediate sodium and glucose transport across cell membranes. SGLT2 inhibitors have a recognized place within heart failure (HF) guidelines. We evaluated the effect of sotagliflozin on HF and cardiovascular outcomes in participants with type 2 diabetes. Scopus, Medline, Embase and Central were searched from
Maria Anna Bantounou, Panagiotis Sardellis, Josip Plascevic, Ribeya Awaes‐Mahmood, Justyna Kaczmarek, Daniel Black Boada, Rosa Thuemmler, Sam Philip   +7 more
wiley   +1 more source