Results 51 to 60 of about 1,116 (166)

Kidney Tubules — Scientific and Applied Value

Архивъ внутренней медицины, 2022
Currently, there is a high scientific interest in studying the features of the structure and functions of the tubules of the kidneys. The relevance of the topic is due to the potential possibility of identifying various markers of tubular dysfunction and
E. s Levitskaya, M. M. Batiushin
doaj   +1 more source

A Multivariable Prediction Model for Early Mortality in Multiple Myeloma Patients With Renal Impairment

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Despite therapeutic advances, early mortality remains a significant challenge in multiple myeloma (MM) patients with renal impairment (RI), with no validated prognostic models currently available for this high‐risk subgroup. This multicenter, retrospective study aimed to develop and validate a practical nomogram for predicting early death ...
Menghan Liu, Yuan Jian, Huixing Zhou, Jing Jia, Jiachen Li, Chuanying Geng, Guangzhong Yang, Wenrong Huang, Xinan Cen, Wenming Chen, Honghu Zhu, Wen Gao   +11 more
wiley   +1 more source

Reduced Expression of Magnesium Transport Proteins in the Distal Convoluted Tubule of Clcnkb‐Deficient Mice May Explain Urinary Magnesium Wasting in Classical Bartter Syndrome

Acta Physiologica, Volume 242, Issue 9, September 2026.
ABSTRACT Aim The kidney thick ascending limb (TAL) plays a key role in the transport of sodium, chloride, potassium, calcium, and magnesium. Bartter syndrome is a hypokalemic, salt‐losing tubulopathy caused by impaired TAL function. Pathogenic variants in SLC12A1 or KCNJ1 cause antenatal Bartter syndrome, and variants in CLCNKB result in classical ...
Marleen L. A. Kortenoeven, Milos Bogdanovic, Ida Appel, Karsten Skjødt, Ernst‐Martin Fuchtbauer, Kirsten Madsen, Lars Lund, Régine Chambrey, Dominique Eladari, R. Todd Alexander, Christian A. Hübner, J. Christopher Hennings, Henrik Dimke   +12 more
wiley   +1 more source

The lipidome of the kidney tubules of ob/ob mice is affected at the infralesional level

Cell Death Discovery
Whether changes in tubular lipidomic composition precede the onset of observable kidney damage in obesity is unknown. We manually isolated the proximal convoluted tubule (PCT), the cortical thick ascending limb of Henle’s loop (cTAL) and the cortical ...
Lydie Cheval, Julio L. Sampaio, Virginie Poindessous, Gilles Crambert, Nicolas Pallet   +4 more
doaj   +1 more source

Urine electrolytes guide treatment of Gitelman syndrome and recurrent syncope—A case report

Physiological Reports, Volume 14, Issue 18, September 2026.
Abstract Syncope is a common reason for inpatient admission. Few case studies describe an association between syncope and Gitelman syndrome (GS). Herein, we present a case of a woman with hypokalemia and recurrent syncope which eventually led to a diagnosis of GS. A physiologic approach to urine electrolyte interpretation informed clinical decisions to
Saloni Agrawal, Kenneth M. Fifer, Samira S. Farouk, Joshua L. Rein   +3 more
wiley   +1 more source

Paroxysmal Kinesigenic Dyskinesia and Progressive Ataxia‐Spasticity Syndrome Caused by a Biallelic Variant in KCNJ10

Movement Disorders Clinical Practice, EarlyView.
Clément Desjardins, Jiyoon Baik, Lorenzo Bresciani, Christelle Nilles, Cendrine Foucard, Mathieu Georget, Lina Daghsen, Bertrand Degos, Aurélie Méneret, Emmanuel Roze   +9 more
wiley   +1 more source

Transient Renal Tubulopathy: A Case Report

Renal Failure, 2008
A five-year-old boy was evaluated for fever, abdominal pain, vomiting, and diarrhea lasting two days. Chest radiograph revealed a left bronchopneumonia. Metabolic work-up demonstrated phosphaturia, glucosuria, calciuria, proteinuria, profound hypophosphatemia, hypouricemia, borderline hypomagnesemia, and normoglycemia.
Shira, Shacham, Michael, Goldman, Mordechai, Aladjem, Tzvy, Bistritzer   +3 more
openaire   +2 more sources

Lipidomic Profiling of Kidney Cortical Tubule Segments Identifies Lipotypes with Physiological Implications

Function
A detailed knowledge of the lipid composition of components of nephrons is crucial for understanding physiological processes and the development of kidney diseases. However, the lipidomic composition of kidney tubular segments is unknown.
Lydie Cheval, Virginie Poindessous, Julio L Sampaio, Gilles Crambert, Nicolas Pallet   +4 more
doaj   +1 more source

The serine‐threonine kinase PIM3 is an aldosterone‐regulated protein in the distal nephron

Physiological Reports, 2019
The mineralocorticoid hormone aldosterone plays a crucial role in the control of Na+ and K+ balance, blood volume, and arterial blood pressure, by acting in the aldosterone‐sensitive distal nephron (ASDN) and stimulating a complex transcriptional ...
Alessia Spirli, Lydie Cheval, Anne Debonneville, David Penton, Caroline Ronzaud, Marc Maillard, Alain Doucet, Johannes Loffing, Olivier Staub   +8 more
doaj   +1 more source

Clinicopathological findings, correlations and outcomes in patients with renal disease and living with antiretroviral‐treated human immunodeficiency virus infection

Internal Medicine Journal, Volume 56, Issue 8, Page 1402-1411, August 2026.
Abstract Background and Aims Antiretroviral therapy (ART) has modified the incidence of renal complications and the patterns of renal disease in people living with Human Immunodeficiency Virus (PLWH). We reviewed (2011–2021) the progress and outcomes (follow‐up to mid‐2025) of 158 such individuals.
Jacqueline A. Evans, Christopher S. B. Sia, Gopal Basu, Orla O’Brien, Alan H. Pham, Rowan G. Walker   +5 more
wiley   +1 more source