Results 1 to 10 of about 7,541,678 (261)

Clinical Genetic Testing in Children with Kidney Disease [PDF]

Childhood Kidney Diseases, 2021
Chronic kidney disease, the presence of structural and functional abnormalities in the kidneys, is associated with a lower quality of life and increased morbidity and mortality in children.
Eungu Kang, Beom Hee Lee
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Combined Preimplantation Genetic Testing for Genetic Kidney Disease: Genetic Risk Identification, Assisted Reproductive Cycle, and Pregnancy Outcome Analysis [PDF]

Frontiers in Medicine, 2022
BackgroundGenetic kidney disease is a major cause of morbidity and mortality in neonates and end-stage renal disease (ESRD) in children and adolescents. Genetic diagnosis provides key information for early identification of congenital kidney disease and ...
Min Xiao, Hua Shi, Jia Rao, Yanping Xi, Shuo Zhang, Junping Wu, Saijuan Zhu, Jing Zhou, Hong Xu, Caixia Lei, Xiaoxi Sun, Xiaoxi Sun   +11 more
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Coexisting genetic kidney disease explains many cases of ‘familial’ IgA nephropathy where the proband has biopsy-confirmed mesangial IgA deposits [PDF]

Frontiers in Medicine
BackgroundOne in seven people with IgA nephropathy has another apparently-affected family member. This study examined how often biopsy-proven familial and sporadic IgA nephropathy were associated with genetic kidney disease.MethodsEleven unrelated people
YuXin Li, Jing Zhang, Zhuo Jun Yin, Ziming Zhou, Bocheng Huang, Khalid Mahmood, Deb Colville, David Barit, Russell Auwardt, Robert Fassett, Kathy Paizis, Francesco Ierino, Timothy Pianta, David Langsford, Mary Huang, Judy Savige   +15 more
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Autosomal dominant tubulointerstitial kidney disease-UMOD is the most frequent non polycystic genetic kidney disease [PDF]

BMC Nephrology, 2018
Background Autosomal dominant tubulointerstitial kidney disease (ADTKD) caused by mutations in the UMOD gene (ADTKD-UMOD) is considered rare and often remains unrecognised.
Christine Gast, Anthony Marinaki, Monica Arenas-Hernandez, Sara Campbell, Eleanor G. Seaby, Reuben J. Pengelly, Daniel P. Gale, Thomas M. Connor, David J. Bunyan, Kateřina Hodaňová, Martina Živná, Stanislav Kmoch, Sarah Ennis, G. Venkat-Raman   +13 more
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Genetic Kidney Disease in Southern Tasmania [PDF]

Kidney International Reports, 2020
Gabrielle Brailsford, Ellie Cash, Jo Burke, Geoff Kirkland, Mathew Wallis, Andrew Mallett, Matthew D. Jose   +6 more
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Robo2 and Gen1 Coregulate Ureteric Budding by Activating the MAPK/ERK Signaling Pathway in Mice

Frontiers in Medicine, 2022
Congenital anomalies of the kidney and urinary tract (CAKUT) are some of the most common developmental defects and have a complicated etiology, indicating an interaction of (epi-) genetic and environmental factors.
Yaxin Li, Minghui Yu, Lihong Tan, Shanshan Xue, Xuanjin Du, Xiaohui Wu, Xiaohui Wu, Hong Xu, Qian Shen   +8 more
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Intrauterine Low-Protein Diet Exacerbates Abnormal Development of the Urinary System in Gen1-Mutant Mice

Kidney Diseases, 2021
Background: Gen1 mutation can cause various phenotypes of congenital anomaly of the kidney and urinary tract (CAKUT). An intrauterine low-protein isocaloric diet can also cause CAKUT phenotypes in offspring.
Minghui Yu, Yaxin Li, Lihong Tan, Jing Chen, Yihui Zhai, Jia Rao, Xiaoyan Fang, Jialu Liu, Jiaojia Liu, Xiaohui Wu, Hong Xu, Qian Shen   +11 more
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Overexpression of Long Non-coding RNA 4933425B07Rik Causes Urinary Malformations in Mice

Frontiers in Cell and Developmental Biology, 2021
Congenital anomalies of the kidney and urinary tract (CAKUT) is a common birth defect and is the leading cause of end-stage renal disease in children. The etiology of CAKUT is complex and includes mainly genetic and environmental factors.
Lihong Tan, Minghui Yu, Yaxin Li, Shanshan Xue, Jing Chen, Yihui Zhai, Xiaoyan Fang, Jialu Liu, Jiaojiao Liu, Xiaohui Wu, Xiaohui Wu, Hong Xu, Qian Shen   +12 more
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LINC00467 Is Upregulated by DNA Copy Number Amplification and Hypomethylation and Shows ceRNA Potential in Lung Adenocarcinoma

Frontiers in Endocrinology, 2022
Lung adenocarcinoma (LUAD) is the most common histological lung cancer, and it is the leading cause of cancer-related deaths worldwide. Long noncoding RNAs (lncRNAs) have been implicated in tumorigenesis.
Wen Wang, Hao Bo, Yumei Liang, Yumei Liang, Yumei Liang, Guoli Li, Guoli Li, Guoli Li   +7 more
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Overexpression of long noncoding RNA 4933425B07Rik leads to renal hypoplasia by inactivating Wnt/β-catenin signaling pathway

Frontiers in Cell and Developmental Biology, 2023
Congenital anomalies of the kidney and urinary tract (CAKUT) is a general term for a class of diseases that are mostly caused by intrauterine genetic development limitation.
Shanshan Xue, Xuanjin Du, Minghui Yu, Haixin Ju, Lihong Tan, Yaxin Li, Jialu Liu, Chunyan Wang, Xiaohui Wu, Xiaohui Wu, Hong Xu, Qian Shen   +11 more
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