Results 41 to 50 of about 7,541,678 (261)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Genetic and environmental risk factors for chronic kidney disease

, 2017
In order to change the current state of chronic kidney disease knowledge and therapeutics, a fundamental improvement in the understanding of genetic and environmental causes of chronic kidney disease is essential.
Peter Stenvinkel, Fox, Caroline S., Carol Pollock, Pollock, Carol, Ulla T. Schultheiss, Correa-Rotter, Ricardo C., Anna Köttgen, Stenvinkel, Peter, Pecoits-Filho, Roberto, Robyn G. Langham, Robert Walker, Kretzler, Matthias, Köttgen, Anna, Yang, Chih-Wei, Walker, Robert, Obrador, Gregorio T., Schultheiß, Ulla Teresa, Matthias Kretzler, Jerome Rossert, Caroline S. Fox, Masaomi Nangaku, Roberto Pecoits-Filho, Nangaku, Masaomi, Chih-Wei Yang, Ricardo Correa-Rotter, Gregorio T. Obrador, Rossert, Jerome, Langham, Robyn G., Pecoits-Filho, R, Correa-Rotter, R, Schultheiss, UT, Rossert, J, Kretzler, M, Obrador, GT, Nangaku, M, Langham, RG, Stenvinkel, P,, Pollock, C   +37 more
core   +1 more source

Genetics of vesicoureteral reflux and congenital anomalies of the kidney and urinary tract [PDF]

Investigative and Clinical Urology, 2017
The definition of congenital anomalies of the kidney and urinary tract (CAKUT) is the disease of structural malformations in the kidney and/or urinary tract containing vesicoureteral reflux (VUR).
Keum Hwa Lee, Heon Yung Gee, Jae Il Shin
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The HIDDEN Protocol: An Australian Prospective Cohort Study to Determine the Utility of Whole Genome Sequencing in Kidney Failure of Unknown Aetiology

Frontiers in Medicine, 2022
Early identification of genetic kidney disease allows personalised management, clarification of risk for relatives, and guidance for family planning. Genetic disease is underdiagnosed, and recognition of genetic disease is particularly challenging in ...
Jacqueline Soraru, Sadia Jahan, Sadia Jahan, Catherine Quinlan, Catherine Quinlan, Catherine Quinlan, Catherine Quinlan, Cas Simons, Cas Simons, Louise Wardrop, Louise Wardrop, Rosie O’Shea, Rosie O’Shea, Alasdair Wood, Alasdair Wood, Amali Mallawaarachchi, Amali Mallawaarachchi, Amali Mallawaarachchi, Chirag Patel, Chirag Patel, Zornitza Stark, Zornitza Stark, Zornitza Stark, Andrew John Mallett, Andrew John Mallett, Andrew John Mallett, Andrew John Mallett, Andrew John Mallett   +27 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Case report: Genotype-phenotype characteristics of nine novel PKD1 mutations in eight Chinese patients with autosomal dominant polycystic kidney disease

Frontiers in Medicine, 2023
IntroductionAutosomal dominant polycystic kidney disease (ADPKD) is a common genetic disorder. The PKD1 gene is responsible for the majority of ADPKD cases, and the mutations in this gene exhibit high genetic diversity.
Jing Zhuang, Ailima Aierken, Dilina Yalikun, Jun Zhang, Xiaoqin Wang, Yongfang Ren, Xuefei Tian, Hong Jiang   +7 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

MicroRNAs and Polycystic Kidney Disease

, 2015
MicroRNAs (miRNAs) are a class of small non protein-coding RNAs that function as inhibitors of post-transcriptional gene expression in plants and animals. Over a thousand different miRNAs are known to be encoded by the human genome, the majority of which

core   +1 more source

KDIGO 2022 CLINICAL PRACTICE GUIDELINE FOR THE PREVENTION, DIAGNOSIS, EVALUATION, AND TREATMENT OF HEPATITIS C IN CHRONIC KIDNEY DISEASE

, 2022
The Kidney Disease: Improving Global Outcomes (KDIGO) 2022 Clinical Practice Guideline for the Prevention, Diagnosis, Evaluation, and Treatment of Hepatitis C in Chronic Kidney Disease represents a focused update of the 2018 guideline.
Jadoul, Michel, Goldberg, David, Martin, Paul, Kidney Disease: Improving Global Outcomes (KDIGO) Hepatitis C Work Group   +3 more
core   +1 more source