Results 51 to 60 of about 7,541,678 (261)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Advancements in Research on Genetic Kidney Diseases Using Human-Induced Pluripotent Stem Cell-Derived Kidney Organoids

Cells
Genetic or hereditary kidney disease stands as a pivotal cause of chronic kidney disease (CKD). The proliferation and widespread utilization of DNA testing in clinical settings have notably eased the diagnosis of genetic kidney diseases, which were once ...
Do Hyun Na, Sheng Cui, Xianying Fang, Hanbi Lee, Sang Hun Eum, Yoo Jin Shin, Sun Woo Lim, Chul Woo Yang, Byung Ha Chung   +8 more
doaj   +1 more source

Attitudes and Practices of Australian Nephrologists Toward Implementation of Clinical Genomics

Kidney International Reports, 2021
Introduction: Genomic testing is becoming widely available as a diagnostic tool, although widespread implementation is not yet established in nephrology.
Kushani Jayasinghe, Catherine Quinlan, Andrew J. Mallett, PhD, Peter G. Kerr, Belinda McClaren, Amy Nisselle, Amali Mallawaarachchi, Kevan R. Polkinghorne, Chirag Patel, Stephanie Best, Zornitza Stark   +10 more
doaj   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Neutralization of the PTX3/CD44 axis suppresses TGF‐β1 signaling in kidney fibrosis

FEBS Letters, EarlyView.
This study investigates how the PTX3/CD44 axis promotes kidney fibrosis by activating TGF‐β1 signaling. We demonstrate that the neutralizing antibody WHC‐001 effectively inhibits this pathway, suppressing myofibroblast activation and partial epithelial–mesenchymal transition (EMT).
Chao‐Chun Cheng, Shen‐Shin Chang, Feng‐Wei Chen, Ying‐Chieh Su, Thanh Phuong Nguyen, Yu‐Wei Hsiao, Jhih‐Ying Chi, Hsin‐Yin Liang, Ju‐Ming Wang   +8 more
wiley   +1 more source

Male reproductive surgeries and long-term kidney outcomes: a Mendelian randomization and meta-analysis of UK Biobank and FinnGen

Renal Failure
The long-term renal implications of conditions leading to male reproductive surgeries remain unclear. This study evaluated the potential causal relationships between genetic liability to undergoing these surgeries and kidney diseases.
Dianjie Zeng, Lingfei Zhu, Li Shi, Yuxi Wang, Jiachen Liu, Yi Peng, Xiaokun Zhao, Yinhuai Wang, Liya Sun, Haiqing He   +9 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Hepatitis B and C co-Infection are independent predictors of progressive kidney disease in HIV-positive, antiretroviral-treated adults [PDF]

, 2012
Chronic kidney disease (CKD) is an important cause of morbidity and mortality in HIV-positive individuals. Hepatitis C (HCV) co-infection has been associated with increased risk of CKD, but prior studies lack information on potential mechanisms.
Bickel, M, ESPRIT Study Group, Amanda Mocroft, Christina M Wyatt, Ross, Michael J., Aleksandra Szymczak, ESPRIT Study Group, Daniel Grint, Jens Lundgren, Ryom, Lene, Lene Ryom, Neuhaus, Jacqueline, Bickel, Markus, Szymczak, A, Peters, L, Jacqueline Neuhaus, Ross, MJ, Michael J Ross, Koirala, J, Neuhaus, J, Szymczak, Aleksandra, Mocroft, Amanda, Peters, Lars, Grint, D, Markus Bickel, Grint, Daniel, Wyatt, CM, Janak Koirala, INSIGHT SMART Study Group, Lundgren, Jens, Ross, Michael J, Koirala, Janak, Ryom, L, Mocroft, A, Lars Peters, Lundgren, J, Wyatt, Christina M, Wyatt, Christina M.   +37 more
core   +1 more source

Monogenic kidney disease and monogenic diabetes are present in renal clinic patients with non-genetic diagnoses

Scientific Reports
Genetic disease is often unrecognised. This study examined how often renal clinic patients, with a non-genetic diagnosis and without a family history of genetic disease recorded at the last three visits, had an underlying genetic form of kidney disease ...
Mary Huang, Timothy Pianta, David Barit, Khalid Mahmood, Deb Colville, Heather Mack, Judy Savige   +6 more
doaj   +1 more source

Review of childhood genetic nephrolithiasis and nephrocalcinosis

Frontiers in Genetics
Nephrolithiasis (NL) is a common condition worldwide. The incidence of NL and nephrocalcinosis (NC) has been increasing, along with their associated morbidity and economic burden.
Ashley M. Gefen, Joshua J. Zaritsky
doaj   +1 more source