Results 11 to 20 of about 347,411 (156)

Friend or Foe? The fascinating Tudor-SN protein [PDF]

Visualized Cancer Medicine, 2023
Tudor-SN (Tudor staphylococcal nuclease), also known as p100 or SND1 (Staphylococcal nuclease and Tudor domain containing 1), is a structurally conserved protein with diverse functions. Emerging evidence indicates that Tudor-SN plays an essential role in
Gao Xingjie, Xin Lingbiao, Yao Zhi, Silvennoinen Olli, Yang Jie   +4 more
doaj   +4 more sources

Tudor-SN protein expression in colorectal cancer and its association with clinical characteristics

Open Life Sciences, 2017
Tudor-SN protein (SND1) is known to be up-regulated in some types of human malignancies and functions as an oncogene. The objective of our study was to investigate the expression and prognostic value of SND1 in human colorectal cancer (CRC).
Zhu Weifang, Tan Shiyun
doaj   +3 more sources

Tudor-SN promotes cardiomyocyte proliferation and neonatal heart regeneration through regulating the phosphorylation of YAP

Cell Communication and Signaling
Background The neonatal mammalian heart exhibits considerable regenerative potential following injury through cardiomyocyte proliferation, whereas mature cardiomyocytes withdraw from the cell cycle and lose regenerative capacities.
Chao Su, Jinzheng Ma, Xuyang Yao, Wei Hao, Shihu Gan, Yixiang Gao, Jinlong He, Yuanyuan Ren, Xingjie Gao, Yi Zhu, Jie Yang, Minxin Wei   +11 more
doaj   +4 more sources

Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G₁/S phase transition. [PDF]

Science, 2017
Breaking down miRNAs Although much work has examined microRNA (miRNA) biogenesis, relatively little is known about miRNA decay. Elbarbary et al. now identify Tudor-SN, an endonuclease that interacts with the
Elbarbary RA, Miyoshi K, Myers JR, Du P, Ashton JM, Tian B, Maquat LE, Maquat LE.   +7 more
europepmc   +5 more sources

Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing. [PDF]

Nucleic Acids Res, 2008
Human Tudor-SN is involved in the degradation of hyper- edited inosine- containing microRNA precursors, thus linking the pathways of RNA interference and editing.
Li CL, Yang WZ, Chen YP, Yuan HS.
europepmc   +5 more sources

Structure and ligand binding of the extended Tudor domain of D. melanogaster Tudor-SN.

Journal of Molecular Biology, 2009
The Tudor-SN protein (p100, SND1) has been implicated in a variety of cellular processes, Such as transcription, processing of edited double-stranded RNA, and splicing regulation. Molecular details of these functions are not vet understood. Tudor domains
Mourao, A., Sattler, M., Friberg, A.R., Corsini, L., Anders Friberg, Michael Sattler, André Mourão, Lorenzo Corsini   +7 more
core   +3 more sources

Translation of Tudor-SN, a novel terminal oligo-pyrimidine (TOP) mRNA, is regulated by the mTORC1 pathway in cardiomyocytes. [PDF]

RNA Biol, 2021
The mechanisms that regulate cell-cycle arrest of cardiomyocytes during heart development are largely unknown. We have previously identified Tudor staphylococcal nuclease (Tudor-SN) as a cell-cycle regulator and have shown that its expression level was closely related to cell-proliferation capacity.
Gan S, Su C, Ma J, Liu M, Cui X, Xin L, Ren Y, Gao X, Ge L, Wei M, Yang J.   +10 more
europepmc   +4 more sources

Tudor-SN and ADAR1 are components of cytoplasmic stress granules. [PDF]

RNA, 2012
Hyperediting by adenosine deaminases that acts on RNA (ADARs) may result in numerous Adenosine-to-Inosine (A-to-I) substitutions within long dsRNA. However, while countless RNAs may undergo hyperediting, the role for inosine-containing hyperedited dsRNA (IU-dsRNA) in cells is poorly understood.
Weissbach R, Scadden AD.
europepmc   +4 more sources

Oncoprotein Tudor-SN is a key determinant providing survival advantage under DNA damaging stress. [PDF]

Cell Death Differ, 2018
Herein, Tudor-SN was identified as a DNA damage response (DDR)-related protein that plays important roles in the early stage of DDR. X-ray or laser irradiation could evoke the accumulation of Tudor-SN to DNA damage sites in a poly(ADP-ribosyl)ation-dependent manner via interaction with PARP-1. Additionally, we illustrated that the SN domain of Tudor-SN
Fu X, Zhang C, Meng H, Zhang K, Shi L, Cao C, Wang Y, Su C, Xin L, Ren Y, Zhang W, Sun X, Ge L, Silvennoinen O, Yao Z, Yang X, Yang J.   +16 more
europepmc   +4 more sources

ENDONUCLEASE V: FROM TRANSCRIPTOME REGULATOR TO CHEMICAL BIOLOGY TOOL. [PDF]

ChemistryEurope
Post‐transcriptional modifications play a pivotal role in regulating the health and physiology of human cells, and adenosine‐to‐inosine (A‐to‐I) editing is one of the most abundant of these modifications. Inosine is read as guanosine by the cellular machinery, and this change impacts both the regulation and genetic code of RNA, in turn effectively ...
Thota P, Todd T, Purohit D, Cheng W, Aastha, Heemstra JM.   +5 more
europepmc   +2 more sources