Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5
Frontiers in Oncology, 2022 Staphylococcal nuclease domain-containing protein 1 (SND1) is an evolutionarily conserved multifunctional protein that functions mainly in the nucleus and cytoplasm.
Liang Chen, Linchong Sun, Ping Gao
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SREBF1-mediated SND1 transcriptional activation promotes prostate cancer progression via MTDH interaction through the SESN2/AMPK/mTOR axis [PDF]
Journal of Translational MedicineBackground Prostate cancer (PCa) is a prevalent cancer and a major cause of cancer-related deaths in men worldwide. Growing evidence indicates that Staphylococcal nuclease and Tudor domain containing 1 (SND1) is a multifunctional protein extensively ...
Yijie Tang +13 more
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lncRNA SND1-IT1/miR-494-3p regulation in ox-LDL-induced endothelial cell injury: novel insights into coronary heart disease pathogenesis and diagnostic biomarkers [PDF]
European Journal of Medical ResearchObjectives Coronary heart disease (CHD) is a major challenge in cardiovascular disease. This study investigated the role of lncRNA SND1-IT1 in oxidized low-density lipoprotein (ox-LDL)-induced injury of human umbilical vein endothelial cells (HUVECs ...
Yanxu Song, Zhexun Lian
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Insights Into SND1 Oncogene Promoter Regulation
Frontiers in Oncology, 2018 The staphylococcal nuclease and Tudor domain containing 1 gene (SND1), also known as Tudor-SN, TSN or p100, encodes an evolutionarily conserved protein with invariant domain composition.
Maria José Martinez, Begoña Ochoa
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CDK1-mediated phosphorylation of USP37 regulates SND1 stability and promotes oncogenesis in colorectal cancer [PDF]
Acta Pharmaceutica Sinica BColorectal cancer (CRC) poses a severe global health challenge with high incidence and mortality rates. USP37 has been identified as the bona fide deubiquitinase of SND1, playing a critical role in stabilizing SND1, thereby augmenting its oncogenic ...
Liang Wu +9 more
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Discovery of novel SND1 inhibitors by in silico–based molecular docking and dynamics simulation methods for managing hepatocellular carcinoma [PDF]
Scientific ReportsHepatocellular carcinoma (HCC) is one of the life–threatening cancers in the current decade. Earlier reports suggest that protein arginine methyl transferase 5 (PRMT5) is also linked with HCC, and the symmetrically dimethylated arginine marks created by ...
Yuvaraj Ravikumar +5 more
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Nucleocapsid protein captures DDX5 and RNMT facilitating viral RNA synthesis and viral protein translation for coronavirus replication [PDF]
mBioCoronaviruses (CoVs) hijack host RNA-binding proteins (RBPs) to facilitate their replication, but the viral proteins and host RBDs that participate in the synthesis of viral RNA and protein are unclear.
Yuchang Liu +14 more
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The crosstalk between SND1 and PDCD4 is associated with chemoresistance of non-small cell lung carcinoma cells [PDF]
Cell Death DiscoveryLung cancer is the leading cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) is highly resistant to chemo- or radiation therapy, which poses a huge challenge for treatment of advanced NSCLC.
Yun Zhao +3 more
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FEBS Open Bio, 2014 Staphylococcal nuclease domain containing-1 (SND1) is overexpressed in human hepatocellular carcinoma (HCC) patients and promotes tumorigenesis by human HCC cells.
Paul B Fisher +2 more
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Proteomics discovery of MTDH and SND1 interaction vulnerabilities in ovarian cancer [PDF]
Scientific ReportsHigh-grade serous ovarian cancer (HGSOC) is the most prevalent and aggressive subtype of ovarian cancer. The combination of late-stage diagnosis and the tendency to exhibit resistance to existing treatments highlights a critical gap in effective ...
Parisa Esmaeili +7 more
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