Results 41 to 50 of about 2,855 (178)

Breaking the oncogenic alliance: advances in disrupting the MTDH-SND1 complex for cancer therapy. [PDF]

RSC Adv
Disruption of the MTDH–SND1 complex using peptide or small-molecule inhibitors triggers SND1 degradation, suppresses oncogenic signaling pathways, and produces potent antitumor effects in preclinical cancer models.
Ahmed NA, Allam AA, Rudayni HA, Aba Alkhayl FF, Lamsabhi AM, Kamel EM.   +5 more
europepmc   +3 more sources

Exosome-mediated lncRNA SND1-IT1 from gastric cancer cells enhances malignant transformation of gastric mucosa cells via up-regulating SNAIL1

Journal of Translational Medicine, 2022
Background Gastric cancer (GC), as one of the most common malignancies across the globe, is the fourth leading cause of cancer-related deaths. Though a large body of research has been conducted to develop the therapeutic methods of GC, the survival rate ...
Guohua Jin, Jianguang Zhang, Tingting Cao, Bang Chen, Yu Tian, Yang Shi   +5 more
doaj   +1 more source

Image_3_Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.jpg

, 2022
Staphylococcal nuclease domain-containing protein 1 (SND1) is an evolutionarily conserved multifunctional protein that functions mainly in the nucleus and cytoplasm.
Caixia Suo (12325550), Haoran Wei (1924189), Shengqi Shen (12325559), Ping Gao (172038), Xuemei Gu (6905417), Mengqiu Yuan (12325556), Chuxu Zhu (12325547), Yingxuan Yu (12325553), Liang Chen (73736), Linchong Sun (12325568), Shiting Li (2854022), Shiwei Liang (442903)   +11 more
core   +1 more source

Inhibition of RNA Binding in SND1 Increases the Levels of miR-1-3p and Sensitizes Cancer Cells to Navitoclax [PDF]

, 2022
SIMPLE SUMMARY: Despite of decades of intensive research, several cancer types, for example aggressive colon cancers, are still difficult to treat, and life expectancy is low.
Martinez Nieto, Guillermo, Lehmusvaara, Saara, Saarikettu, Juha, Haikarainen, Teemu, Saara Lehmusvaara, Olli Silvennoinen, Teemu Haikarainen, Juha Saarikettu, Guillermo Martinez Nieto, Silvennoinen, Olli, Nieto, Guillermo Martinez   +10 more
core   +1 more source

Table_2_Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.doc

, 2022
Staphylococcal nuclease domain-containing protein 1 (SND1) is an evolutionarily conserved multifunctional protein that functions mainly in the nucleus and cytoplasm.
Caixia Suo (12325550), Haoran Wei (1924189), Shengqi Shen (12325559), Ping Gao (172038), Xuemei Gu (6905417), Mengqiu Yuan (12325556), Chuxu Zhu (12325547), Yingxuan Yu (12325553), Liang Chen (73736), Linchong Sun (12325568), Shiting Li (2854022), Shiwei Liang (442903)   +11 more
core   +1 more source

Image_1_Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.jpg

, 2022
Staphylococcal nuclease domain-containing protein 1 (SND1) is an evolutionarily conserved multifunctional protein that functions mainly in the nucleus and cytoplasm.
Caixia Suo (12325550), Haoran Wei (1924189), Shengqi Shen (12325559), Ping Gao (172038), Xuemei Gu (6905417), Mengqiu Yuan (12325556), Chuxu Zhu (12325547), Yingxuan Yu (12325553), Liang Chen (73736), Linchong Sun (12325568), Shiting Li (2854022), Shiwei Liang (442903)   +11 more
core   +1 more source

Image_2_Mitochondrion-Localized SND1 Promotes Mitophagy and Liver Cancer Progression Through PGAM5.jpg

, 2022
Staphylococcal nuclease domain-containing protein 1 (SND1) is an evolutionarily conserved multifunctional protein that functions mainly in the nucleus and cytoplasm.
Caixia Suo (12325550), Haoran Wei (1924189), Shengqi Shen (12325559), Ping Gao (172038), Xuemei Gu (6905417), Mengqiu Yuan (12325556), Chuxu Zhu (12325547), Yingxuan Yu (12325553), Liang Chen (73736), Linchong Sun (12325568), Shiting Li (2854022), Shiwei Liang (442903)   +11 more
core   +1 more source

Inhibition of SND1 overcomes chemoresistance in bladder cancer cells by promoting ferroptosis

Oncology Reports, 2022
Chemotherapy remains one of the most important adjuvant treatments for bladder cancer (BC). However, similar to other malignancies, BC is prone to chemotherapy resistance and only approximately half of muscle‑invasive patients with BC respond to chemotherapy. The present study aimed to reveal the mechanisms underlying chemoresistance in BC cells.
Zhao, Yu, Ren, Pengpeng, Yang, Zhiqin, Wang, Lei, Hu, Changhua   +4 more
openaire   +2 more sources

miRNA-296-5p functions as a potential tumor suppressor in human osteosarcoma by targeting SND1

Chinese Medical Journal, 2021
. Background:. The pathogenesis of osteosarcoma (OS) is still unclear, and it is still necessary to find new targets and drugs for anti-OS. This study aimed to investigate the role and mechanism of the anti-OS effects of miR-296-5p. Methods:. We measured
Ya-Zeng Huang, Jun Zhang, Jian-Jian Shen, Ting-Xiao Zhao, You-Jia Xu, Ning-Ning Wang   +5 more
doaj   +1 more source

Additional file 10 of Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling

, 2022
Additional file 10: Fig. S10.Correlation analysis of Tmod3 and SND1/RhoA signaling. (A) The relative expression of LGMN, TMOD3, ACTB, SND1, RHOA and CDK1 in GBM compared to normal brain tissues by GEPIA analysis.
Keman Liao (11611105), Yongming Qiu (171424), Yingying Lin (1790404), Binghong Chen (11080383), Zhonggang Shi (12972190), Qi Lv (169217), Yan Lin (285018), Wenrui Zhang (1486636), Chunhui Ma (668361), Junjun Qiu (10462250), Jiazhou Ye (5712152), Zhongrun Qian (11645269), Rong Liang (587636), Mengying Wang (4443901)   +13 more
core   +1 more source