Results 61 to 70 of about 2,855 (178)

A MYB‐Related Transcriptional Module Cooperatively Represses Xylem Development in Poplar

Plant Biotechnology Journal, Volume 24, Issue 11, Page 5793-5811, November 2026.
ABSTRACT MYB transcription factors play crucial roles in regulating plant growth and development, but the functions of the MYB‐related subfamily in woody plants remain poorly understood. In this study, we characterized PagMYBR028, an MYB‐related transcription factor from poplar ‘84 K’ (Populus alba × Populus glandulosa), which was predominantly ...
Gaofeng Fan, Jiahui Jiang, Zihan Cheng, Feixiang Ma, Zhanling Sun, Zelin Li, Yu Qi, Guanzheng Qu, Tingbo Jiang   +8 more
wiley   +1 more source

N6‐Methyladenosine in Inflammatory Bowel Disease: An Emerging Regulator of Pathogenesis and a Novel Therapeutic Frontier

iMetaMed, Volume 2, Issue 3, September 2026.
Inflammatory bowel disease (IBD) is a chronic inflammatory disorder of the intestine associated with an imbalance in intestinal homeostasis. m6A‐modifying enzymes, consisting of m6A writers, erasers and readers, plays a pivotal role in the pathogenesis and progression of IBD by affecting four intestinal barriers, including the intestinal mechanical ...
Jiaxian Guo, Yang Zhang, Xin Wang, Shan Cao, Jun Xu   +4 more
wiley   +1 more source

Dynamic regulation of pancreatic β cell function and gene expression by the SND1 coregulator in vitro

, 2023
The pancreatic β cell synthesizes, packages, and secretes insulin in response to glucose-stimulation to maintain blood glucose homeostasis. Under diabetic conditions, a subset of β cells fail and lose expression of key transcription factors (TFs ...
Xu, Jerry, Ren, Hongxia, Sims, Emily K., Kanojia, Sukrati, Conley, Jason M., Spaeth, Jason M., Osmulski, Meredith, Davidson, Rebecca K.   +7 more
core   +1 more source

Targeting m6A Modifications Regulating Ferroptosis Offers Novel Therapy in Diseases

Cell Proliferation, Volume 59, Issue 9, September 2026.
m6A RNA modification regulates ferroptosis by balancing iron metabolism, lipid peroxidation, and antioxidant defenses. Dysregulated m6A signaling disrupts pro‐ and anti‐ferroptotic factors, leading to excess ROS, Fe3+ accumulation, and lipid peroxidation–driven cell death. Targeting m6A‐mediated ferroptotic regulation represents a promising therapeutic
Lida Du, Joshua S. Fleishman, Shuang Wu, Yuan Zhou, Clara X. Wang, Haitong Wang, Yumin Wang, Hongquan Wang   +7 more
wiley   +1 more source

Regulation of miR‐17‐92a cluster processing by the microRNA binding protein SND1 [PDF]

FEBS Letters, 2013
MicroRNAs are small non‐coding RNAs that regulate gene expression. Although all seven members of the miR‐17‐92a cluster originate from one primary transcript they are differentially expressed suggesting the presence of posttranscriptional regulation. By RNA pulldown and mass spectrometry we identified SND1, a known regulator of edited RNAs, interacting
Heinrich, Eva-Marie, Wagner, Jasmin, Krüger, Marcus, John, David, Uchida, Shizuka, Weigand, Julia E., Suess, Beatrix, Dimmeler, Stefanie   +7 more
openaire   +2 more sources

Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1

Journal of Neuroinflammation, 2023
Background Circular RNAs (circRNAs) are highly enriched in the central nervous system and have been implicated in neurodegenerative diseases. However, whether and how circRNAs contribute to the pathological processes induced by traumatic brain injury ...
Chunling Huang, Lulu Sun, Chenyang Xiao, Wenjun You, Li Sun, Siye Wang, Zhijun Zhang, Su Liu   +7 more
doaj   +1 more source

Spatiotemporal Metabolome and Single‐Nucleus Transcriptome Integration Illuminates an Auxin Gradient Orchestrated by NtTAC1 Underlying Leaf Angle Regulation in Tobacco

Plant Biotechnology Journal, Volume 24, Issue 8, Page 4897-4915, August 2026.
Proposed model of TAC1‐mediated leaf angle regulation in tobacco. ABSTRACT Plant architecture is key to crop yield, with leaf angle being critical for high‐density cultivation. Although TAC1 represents a promising regulator of leaf angle for breeding, its molecular mechanism remains poorly understood, particularly at single‐nucleus resolution. Here, we
Lin Wang, Junping Gao, Chen Wang, Guoyun Xu, Zhen Ma, Shuaibin Wang, Zhaopeng Luo, Mingzhu Wu, Jianfeng Zhang, Jun Yang, Peijian Cao, Xiaodong Xie   +11 more
wiley   +1 more source

Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism

Journal of Experimental & Clinical Cancer Research, 2022
Background Acquisition of the chemoresistance to docetaxel (DTX), a microtubule-targeting agent, has been a huge obstacle in treatment for metastatic castration-resistant prostate cancer (mCRPC).
Liang Chen, Yarong Song, Teng Hou, Xuexiang Li, Lulin Cheng, Yunxue Li, Yifei Xing   +6 more
doaj   +1 more source

Infusible Extracellular Matrix Biomaterial Enhances Cell‐Specific Pro‐Repair Responses Following Acute Myocardial Infarction

Advanced Healthcare Materials, Volume 15, Issue 27, 17 July 2026.
We measure the cell‐specific responses of administering infusible ECM (iECM) in acute myocardial infarction (MI) across multiple timepoints. Using single‐nucleus RNA sequencing and spatial transcriptomics, we measure macrophage activation, fibroblast remodeling, increased vascular development, lymphangiogenesis, cardioprotection, and neurogenesis ...
Joshua M. Mesfin, Alexander Chen, Quincy P. Lyons, Michael B. Nguyen, Maria L. Karkanitsa, Justin Yu, Van K. Ninh, Emily Gardner, Elyse G. Wong, Sriya N. Paleti, Julian Cheng, Benjamin D. Bridgelal, Kate E. Reimold, Selena Cao, Connor Uhre, Colin G. Luo, Zhenxing Fu, Kevin R. King, Karen L. Christman   +18 more
wiley   +1 more source

ANXA2‐mediated Phagocytosis Generates AR+ Macrophages to Confer Enzalutamide Resistance in Prostate Cancer

Advanced Science, Volume 13, Issue 38, 9 July 2026.
A novel resistance mechanism is mediated through phagocytosis of cancer cells by AR+ TAMs. This process, dependent on ANXA2, enables macrophages to acquire AR protein from engulfed tumor cells. The internalized AR translocates into the macrophage nucleus, where it binds directly to the IL‐6 promoter, augmenting IL‐6 transcription and secretion ...
Yong Luo, Tianlong Luo, Lingfeng Li, Qi Sun, Dongquan Li, Shanhe Huang, Zonglin Li, Weilong Lin, Yuan Ou, Tao Du, Shengmeng Peng, Kewei Xu, Bisheng Cheng, Hai Huang   +13 more
wiley   +1 more source