Exosome-Mediated lncRNA SND1-IT1 From Gastric Cancer Cells Enhances Malignant Transformation of Gastric Mucosa Cells via Up-Regulating SNAIL1 [PDF]
Journal of Translational Medicine, 2022 Background Gastric cancer (GC), as one of the most common malignancies across the globe, is the fourth leading cause of cancer-related deaths. Though a large body of research has been conducted to develop the therapeutic methods of GC, the survival rate ...
GuoHua Jin
exaly +5 more sources
LncRNA SND1-IT1 Facilitates TGF-β1-Induced Epithelial-to-Mesenchymal Transition via miR-124/COL4A1 Axis in Gastric Cancer [PDF]
Cell Death Discovery, 2022 The transformation of tumor cells from an epithelial to a mesenchymal-like phenotype, designated as epithelial-to-mesenchymal transition (EMT), represents a key hallmark of human cancer metastasis, including gastric cancer (GC).
Yun-Long Pan, Yang-Zhi Hu
exaly +6 more sources
lncRNA SND1-IT1/miR-494-3p Regulation in Ox-LDL-Induced Endothelial Cell Injury: Novel Insights Into Coronary Heart Disease Pathogenesis and Diagnostic Biomarkers [PDF]
European Journal of Medical ResearchObjectives Coronary heart disease (CHD) is a major challenge in cardiovascular disease. This study investigated the role of lncRNA SND1-IT1 in oxidized low-density lipoprotein (ox-LDL)-induced injury of human umbilical vein endothelial cells (HUVECs ...
Yanxu Song, Zhexun Lian
exaly +5 more sources
Long Non-Coding RNA SND1-IT1 Accelerates Cell Proliferation, Invasion and Migration via Regulating miR-132-3p/SMAD2 Axis in Retinoblastoma [PDF]
Bioengineered, 2021 Long noncoding RNAs (lncRNAs) have been identified as prognostic biomarkers and functional regulators in human tumors. In our study, we aim to investigate the roles of lncRNA SND1-IT1 (SND1-IT1) in retinoblastoma (RB). We observed that SND1-IT1 was highly expressed in both RB specimens and cells, and associated with poorer prognosis of RB patients ...
Hu Yuan
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Insights Into SND1 Oncogene Promoter Regulation [PDF]
Frontiers in Oncology, 2018 The staphylococcal nuclease and Tudor domain containing 1 gene (SND1), also known as Tudor-SN, TSN or p100, encodes an evolutionarily conserved protein with invariant domain composition.
Maria José Martinez, Begoña Ochoa
exaly +4 more sources
Identification of Differentially Expressed Intronic Transcripts in Osteosarcoma [PDF]
Non-Coding RNA, 2022 Over the past decade; the discovery and characterization of long noncoding RNAs (lncRNAs) have revealed that they play a major role in the development of various diseases; including cancer.
Emel Rothzerg, Jiake Xu, David Wood
doaj +2 more sources
Elucidating the Molecular Mechanism of Ischemic Stroke Using Integrated Analysis of miRNA, mRNA, and lncRNA Expression Profiles [PDF]
Frontiers in Integrative Neuroscience, 2021 Objective: This study aimed to investigate the possible molecular mechanisms associated with ischemic stroke through the construction of a lncRNA-miRNA-mRNA network.
Yaxuan Sun +5 more
doaj +2 more sources
European Review for Medical and Pharmacological Sciences, 2019 To clarify the role of long non-coding RNA (lncRNA) SND1-IT1 in accelerating the proliferative and migratory abilities of osteosarcoma (OS) via sponging miRNA-665 to upregulate POU2F1.The relative level of SND1-IT1 in OS tissues was determined by quantitative Real Time-Polymerase Chain Reaction (qRT-PCR).
Jin, X.-M. +9 more
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lncRNA TMEM51-AS1 and RUSC1-AS1 function as ceRNAs for induction of laryngeal squamous cell carcinoma and prediction of prognosis [PDF]
PeerJ, 2019 Background Long non-coding RNAs (lncRNAs) can function as competing endogenous RNAs (ceRNAs) to interact with miRNAs to regulate target genes and promote cancer initiation and progression.
Lian Hui +3 more
doaj +2 more sources
Identification of JPX-RABEP1 Pair as an Immune-Related Biomarker and Therapeutic Target in Pulmonary Arterial Hypertension by Bioinformatics and Experimental Analyses. [PDF]
Int J Mol Sci, 2022 Gong Q +7 more
europepmc +1 more source