Results 11 to 20 of about 1,856 (117)

Deciphering the role of cuproptosis-related lncRNAs in shaping the lung cancer immune microenvironment: A comprehensive prognostic model. [PDF]

J Cell Mol Med
Abstract Cuproptosis plays an important role in cancer, but its role in lung cancer remains unknown. Transcriptional profiles, clinical details and mutation data were acquired from the Cancer Genome Atlas database through a variety of methods. The analysis of this publicly available data was comprehensively performed using R software along with its ...
Huang H, Chen G, Zhang Z, Wu G, Zhang Z, Yu A, Wang J, Quan C, Li Y, Zhou M.   +9 more
europepmc   +2 more sources

USP3: Key deubiquitylation enzyme in human diseases. [PDF]

Cancer Sci
Abstract Ubiquitination and deubiquitylation are pivotal posttranslational modifications essential for regulating cellular protein homeostasis and are implicated in the development of human diseases. Ubiquitin‐specific protease 3 (USP3), a member of the ubiquitin‐specific protease family, serves as a key deubiquitylation enzyme, playing a critical role
Zhang H, Liu W, Wu Y, Chen C.
europepmc   +2 more sources

Exploring Long Noncoding RNAs as Regulators of Tumor Ferroptosis: Advances and Challenges. [PDF]

Cancer Sci
Long noncoding RNAs (lncRNAs) play pivotal roles in regulating gene expression and are closely associated with cancer progression, prognosis, and therapeutic resistance. This review highlights recent advancements in understanding how lncRNAs modulate ferroptosis, a regulated form of cell death characterized by iron‐dependent lipid peroxidation ...
Li G, Wang B, Ye L, Wang G.
europepmc   +2 more sources

Loss of the Methylarginine Reader Function of SND1 Confers Resistance to Hepatocellular Carcinoma [PDF]

, 2023
Staphylococcal nuclease Tudor domain containing 1 (SND1) protein is an oncogene that \u27reads\u27 methylarginine marks through its Tudor domain. Specifically, it recognizes methylation marks deposited by protein arginine methyltransferase 5 (PRMT5 ...
Liu, Bin, Wang, Yalong, Stratton, Sabrina A, Wright, Tanner, Sebastian, Manu, Johnson, David G, Bedford, Mark T   +6 more
core   +1 more source

LncRNA LINC00534 regulates cell proliferation and migration via the miR‐494‐3p/PTEN axis in HTR‐8/SVneo cells

Journal of Clinical Laboratory Analysis, Volume 37, Issue 1, January 2023., 2023
In this study, we selected one lncRNA named LINC00534 from our previous lncRNAs microarray assays. Subsequently, we found that LINC00534 was highly expressed in placental tissues of patients with preeclampsia. At the same time, our results show that LINC00534 inhibited proliferation and migration in HTR8/SVneo trophoblast cells by adsorbing miR‐494‐3p ...
Xuejing Song, Xinxin Zhang, Qing Xia, Chunyan Li, Yanrong Zhang, Yu Huang, Li Meng, Chunhua Wang, Jingyun Li, Wei Long   +9 more
wiley   +1 more source

lncRNA DARS‐AS1 Promoted Osteosarcoma Progression through Regulating miR‐532‐3p/CCR7

Disease Markers, Volume 2022, Issue 1, 2022., 2022
Background. lncRNAs have been indicated to involve in cell invasion, proliferation, and metastasis. However, function of DARS‐AS1 in osteosarcoma remains poorly explored. Methods. DARS‐AS1 and miR‐532‐3p level were measured using qRT‐PCR. CCK‐8 assay and cell invasion assay were done to study cell functions.
Yan Xue, Hongmiao Liu, Guangchen Nie, Xiaoping Ren, Wen-Jun Tu   +4 more
wiley   +1 more source

A competing endogenous RNA network reveals key lncRNAs associated with sepsis

Molecular Genetics &Genomic Medicine, Volume 9, Issue 1, January 2021., 2021
Abstract Background This study set out to determine key lncRNAs correlated with sepsis via constructing competing endogenous RNA (ceRNA) network. Methods Three septic patients and three healthy controls were recruited to obtain lncRNA profiles in this current study.
Xuan Guo, Yanjun Qin, Lili Wang, Shimin Dong, Yan Yan, Xiaohua Bian, Caiyan Zhao   +6 more
wiley   +1 more source

POU2F1 Promotes Cell Viability and Tumor Growth in Gastric Cancer through Transcriptional Activation of lncRNA TTC3‐AS1

Journal of Oncology, Volume 2021, Issue 1, 2021., 2021
POU domain, class 2, transcription factor 1 (POU2F1) is involved in the development of gastric cancer (GC). However, the molecular mechanism has not been fully elucidated. Here, we identified a novel lncRNA named TTC3‐AS1 that was potentially regulated by POU2F1 and investigated their roles in GC progression. Bioinformatics analysis suggested that high
Jixu Wang, Ke Xiao, Futao Hou, Lusheng Tang, Dan Luo, Gu Liu, Zhiqiang Wang, Raffaele Palmirotta   +7 more
wiley   +1 more source

LncRNA LINC00662 Exerts an Oncogenic Effect on Osteosarcoma by the miR‐16‐5p/ITPR1 Axis

Journal of Oncology, Volume 2021, Issue 1, 2021., 2021
Background. Osteosarcoma (OS) is one of the most malignant bone tumors and has a high metastatic rate. Increasing research has demonstrated the vital roles of long noncoding RNAs (lncRNAs) in human cancers, including OS. LncRNA LINC00662 has been revealed to act as an oncogene involved in multiple tumor progression.
Miao Yu, Weihao Lu, Zhenglin Cao, Tianhang Xuan, Prasanna Kumar Santhekadur   +4 more
wiley   +1 more source

Pravastatin‐induced changes in expression of long non‐coding and coding RNAs in endothelial cells

Physiological Reports, Volume 9, Issue 1, January 2021., 2021
First lncRNA and mRNA expression profiling of pravastatin‐mediated changes in human endothelial cells. We provide the basis for mechanisms associated with pravastatin to improve endothelial function. Abstract Objective Atherosclerosis is the main cause of the cardiovascular disease (CVD).
Shweta Singh, Hien C. Nguyen, Mehroz Ehsan, David C. R. Michels, Priyanka Singh, Mohammad Qadura, Krishna K. Singh   +6 more
wiley   +1 more source