Results 31 to 40 of about 1,856 (117)
, 2023 Breast cancer is the leading cause of cancer-related deaths in women. Previous studies have indicated that disrupting the interaction between Metadherin (MTDH) and Staphylococcal nuclease domain containing 1 (SND1) can inhibit breast cancer development ...
Senchen Liu (16417045) +6 more
core +1 more source
The Role of the PRMT5–SND1 Axis in Hepatocellular Carcinoma
, 2021 Arginine methylation is an essential post-translational modification (PTM) deposited by protein arginine methyltransferases (PRMTs) and recognized by Tudor domain-containing proteins.
Tanner Wright +2 more
core +1 more source
LncRNA RUNX1-IT1 is downregulated in gastric cancer and suppresses the maturation of miR-20a by binding to its precursor [PDF]
, 2023 Background. RUNX1-IT1 has been characterized as a tumor suppressive long non-coding RNA (lncRNA) in several types of cancer but not gastric cancer (GC). This study aimed to explore the role of RUNX1-IT1 in GC. Methods. The expression of RUNX1-IT1,
Bao, Lei +4 more
core +1 more source
A Study of The Snd1/Prmt5 Axis In Liver Cancer By Genetic Mouse Models [PDF]
, 2023 Arginine methylation is an essential post-translational modification (PTM) in cells. Protein arginine methyltransferase 5 (PRMT5) is the primary enzyme that catalyzes symmetric dimethyl arginine (SDMA) and requires methylosome protein 50 (MEP50) for ...
Wright, Tanner
core +1 more source
Structural Insights into the Tumor-Promoting Function of the MTDH-SND1 Complex
, 2014 SummaryMetadherin (MTDH) and Staphylococcal nuclease domain containing 1 (SND1) are overexpressed and interact in diverse cancer types. The structural mechanism of their interaction remains unclear.
Kenneth A. Satyshur +19 more
core +1 more source
N-Glycosylation on Asn50 of SND1 Is Required for Glioma U87 Cell Proliferation and Metastasis
, 2022 Staphylococcal nuclease domain-containing protein 1 (SND1) is an evolutionarily conserved multidomain protein, which has gained attention recently due to its positive regulation in several cancer progression and metastatic spread.
Li, Qingyu +3 more
core +1 more source
Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma
, 2017 SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcinoma (HCC). In this study, we show that hepatocyte-specific SND1 transgenic mice (Alb/SND1 mice) develop spontaneous HCC with partial ...
Paul B. Fisher +11 more
core +1 more source
Proteoglycan Research, Volume 2, Issue 4, October-December 2024.Abstract Antibody and cell‐based therapeutics targeting cell surface receptors have emerged as a major class of immune therapeutics for treating cancer. However, the number of cell surface targets for cancer immunotherapy remains limited. Glypican‐3 (GPC3) is a cell surface proteoglycan and an oncofetal antigen.
Yi‐Fan Zhang +3 more
wiley +1 more source
Exosomes: Toward a potential application in bladder cancer diagnosis and treatment
Smart Medicine, Volume 3, Issue 1, February 2024.Bladder cancer poses a challenge for clinical diagnosis and treatment with the rapid progression and high recurrence rate. Exosomes play a key role in tumor progression. This review comprehensively outlines the biological characteristics of exosomes and their critical roles in tumorigenesis, while also discussing the potential applications in the ...
Xiaowei Wei, Dagan Zhang, Yefei Zhu
wiley +1 more source
, 2021 Objective: This study aimed to investigate the possible molecular mechanisms associated with ischemic stroke through the construction of a lncRNA-miRNA-mRNA network.
Jing Wang (6206297) +5 more
core +1 more source