Results 11 to 20 of about 2,855 (178)
Translational regulation of SND1 governs endothelial homeostasis during stress [PDF]
The Journal of Clinical InvestigationTranslational control shapes the proteome and is particularly important in regulating gene expression under stress. A key source of endothelial stress is treatment with tyrosine kinase inhibitors (TKIs), which lowers cancer mortality but increases ...
Zhenbo Han +14 more
doaj +6 more sources
The Role of the PRMT5–SND1 Axis in Hepatocellular Carcinoma [PDF]
Epigenomes, 2021 Arginine methylation is an essential post-translational modification (PTM) deposited by protein arginine methyltransferases (PRMTs) and recognized by Tudor domain-containing proteins.
Tanner Wright +2 more
doaj +4 more sources
Structural Insights into the Tumor-Promoting Function of the MTDH-SND1 Complex [PDF]
Cell Reports, 2014 Metadherin (MTDH) and Staphylococcal nuclease domain containing 1 (SND1) are overexpressed and interact in diverse cancer types. The structural mechanism of their interaction remains unclear.
Feng Guo +9 more
doaj +4 more sources
N-Glycosylation on Asn50 of SND1 Is Required for Glioma U87 Cell Proliferation and Metastasis
Journal of Immunology Research, 2022 Staphylococcal nuclease domain-containing protein 1 (SND1) is an evolutionarily conserved multidomain protein, which has gained attention recently due to its positive regulation in several cancer progression and metastatic spread.
Ying Zhou +3 more
doaj +4 more sources
Identification and Analysis of SND1 as an Oncogene and Prognostic Biomarker for Lung Adenocarcinoma
Chinese Journal of Lung CancerBackground and objective Transcription factor (TF) can bind specific sequences that either promotes or represses the transcription of target genes, and exerts important effects on tumorigenesis, migration, invasion.
Ruihao ZHANG +9 more
doaj +4 more sources
Loss of the Methylarginine Reader Function of SND1 Confers Resistance to Hepatocellular Carcinoma [PDF]
Biochemical Journal, 2023 Staphylococcal nuclease Tudor domain containing 1 (SND1) protein is an oncogene that \u27reads\u27 methylarginine marks through its Tudor domain. Specifically, it recognizes methylation marks deposited by protein arginine methyltransferase 5 (PRMT5 ...
Liu, Bin +6 more
core +3 more sources
PLoS Pathogens, 2021 To date, no reports have linked the multifunctional protein, staphylococcal nuclease domain-containing protein 1 (SND1), to host defense against intracellular infections.
Xinting Wang +6 more
doaj +2 more sources
Oncogenic Role of SND1 in Development and Progression of Hepatocellular Carcinoma [PDF]
Cancer Research, 2017 SND1, a subunit of the miRNA regulatory complex RISC, has been implicated as an oncogene in hepatocellular carcinoma (HCC). In this study, we show that hepatocyte-specific SND1 transgenic mice (Alb/SND1 mice) develop spontaneous HCC with partial ...
Paul B. Fisher +11 more
core +3 more sources
SREBP-2-driven transcriptional activation of human SND1 oncogene [PDF]
Oncotarget, 2017 Upregulation of Staphylococcal nuclease and tudor domain containing 1 (SND1) is linked to cancer progression and metastatic spread. Increasing evidence indicates that SND1 plays a role in lipid homeostasis.
Leire Enzunza +18 more
core +5 more sources
SND1 mediated downregulation of PTPN23 in HCC [PDF]
, 2014 SND1 MEDIATED DOWNREGULATION OF PTPN23 IN HEPATOCELLULAR CARCINOMA By Nidhi Jariwala, MS A thesis submitted in partial fulfillment of the requirements for the degree of Master of Science at Virginia Commonwealth University, 2014. ADVISOR: Dr.
Jariwala, Nidhi
core +2 more sources