Results 31 to 40 of about 72,617 (249)
Advanced Science, EarlyView.We present a versatile DNA‐encoded library (DEL) platform designed for rapid library synthesis and subsequent screening for chemical inducers of proximity (CIPs) across various presenter proteins of choice. Applying this approach, we discovered a novel molecular glue‐like compound mediating CRBN‐BRD9 ternary complex formation with remarkable ...
Bingqi Tong +11 more
wiley +1 more source
Advanced Science, EarlyView.An MTJ‐based probabilistic processing‐in‐memory architecture unites nonvolatile storage, local entropy generation, and stochastic computation within each memory cell. Stored multi‐bit weights are converted directly into programmable stochastic bitstreams, enabling neural‐network inference, adaptive Ising optimization, and uncertainty‐aware Bayesian ...
Qiuyuan Wang +6 more
wiley +1 more source
Structural basis for recognition of 53BP1 tandem Tudor domain by TIRR
Nature Communications, 2018 The p53-binding protein 1 (53BP1) regulates the choice of the DNA double-strand break repair pathway. Here the authors present the crystal structure of Tudor-interacting repair regulator (TIRR) bound to the 53BP1 tandem Tudor domain, which reveals how ...
Yaxin Dai +4 more
doaj +1 more source
Photovoltaics: New Policy Challenges for Europe
Frontiers in Energy Research, 2013 During the past decade governments across Europe have set in place a series ofprogrammes to expand investment on grid-connected solar power technology, mostespecially Photovoltaics (PV).
Luís Alexandre Duque Moreira De Sousa
doaj +1 more source
Advanced Science, EarlyView.Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao +9 more
wiley +1 more source
Bayesian belief network models for species assessments: An example with the Pacific walrus
Wildlife Society Bulletin, 2013 In 2008, the U.S. Fish and Wildlife Service was petitioned to list the Pacific walrus (Odobenus rosmarus divergens) under the U.S. Endangered Species Act (ESA). Research into stressors that may be negatively affecting walruses is incomplete. We developed
James G. MacCracken +3 more
doaj +1 more source
The History of Tudor Rare Symbols: An Iconographic Study [PDF]
Athens Journal of HistoryIn this essay, I discuss the logic of Tudor symbolism in relation to immediate historical context and iconography. Tudor iconography as a historically established set of visual modes of representation of monarchs and their mainstream political ideas had ...
Natalya Davidko
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Optimizing surveys of fall‐staging geese using aerial imagery and automated counting
Wildlife Society Bulletin, 2023 Ocular aerial surveys allow efficient coverage of large areas and can be used to monitor abundance and distribution of wild populations. However, uncertainty around resulting population estimates can be large due to difficulty in visually identifying and
Emily L. Weiser +6 more
doaj +1 more source
Annals of Neurology, EarlyView.Objective This study assessed the efficacy of thrombectomy in acute ischemic stroke because of large‐vessel occlusion (AIS‐LVO) initially admitted to primary stroke centers (PSC) and subsequently transferred to a comprehensive stroke center (CSC), with a large ischemic core identified before transfer.
Pierre Seners +258 more
wiley +1 more source
Multiple domains of scaffold Tudor protein play nonredundant roles in Drosophila germline
Life Science AllianceMultiple protein–protein interaction domains nonredundantly contribute to the function of Tudor scaffold protein in formation of biomolecular condensates and germline development in Drosophila .
Samuel J Tindell +3 more
doaj +1 more source