Results 31 to 40 of about 2,516 (289)

Considering spatiotemporal evolutionary information in dynamic multi‐objective optimisation

open access: yesCAAI Transactions on Intelligence Technology, EarlyView., 2023
Abstract Preserving population diversity and providing knowledge, which are two core tasks in the dynamic multi‐objective optimisation (DMO), are challenging since the sampling space is time‐ and space‐varying. Therefore, the spatiotemporal property of evolutionary information needs to be considered in the DMO.
Qinqin Fan   +3 more
wiley   +1 more source

Steam Tugboat Explosion [PDF]

open access: yesScientific American, 1881
n ...
openaire   +2 more sources

Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing

open access: yesAdvanced Science, EarlyView.
Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale   +6 more
wiley   +1 more source

Targeting the ATX‐LPA Axis Overcomes TKI Resistance and Immunosuppression in Renal Cell Carcinoma via Dual Inhibition of AKT/mTOR and TBK1/IRF3 Pathways

open access: yesAdvanced Science, EarlyView.
ABSTRACT Background Therapeutic resistance limits durable survival in advanced/metastatic renal cell carcinoma (RCC) treated with first‐line tyrosine kinase inhibitor (TKI) plus immune checkpoint inhibitor (ICI). We sought to define key resistance drivers and actionable targets.
Jinchen Luo   +16 more
wiley   +1 more source

Study on Abilities of Harbour Tugboats

open access: yesJournal of the Society of Naval Architects of Japan, 1987
It is widely known that tugboats play very important roles for harbour manoeuvres of large ships. There have, however, been few researches on abilities of such tugboats.In the present report, an attempt is done to establish the procedure for estimating the abilities of tugboats running with large ships.
Kuniji Kose   +3 more
openaire   +2 more sources

Somatic Evolution of a Germline Antibody Expands its Breadth to Neutralize Early SARS‐CoV‐2 Omicron Variants

open access: yesAdvanced Science, EarlyView.
Engineering of the 148‐germline (148‐GL) antibody reveals a roadmap for overcoming SARS‐CoV‐2 viral escape. By introducing four specific somatic hypermutations, the resulting 148‐M4 variant restores potent neutralization against Omicron BA.1 and BA.4/5.
Huibin Lv   +14 more
wiley   +1 more source

Bioadhesive‐Integrated 3D‐Printed Multilayer Scaffolds Secure a Mechanically‐Stable Osteoimmune Niche for Enhanced Bone Augmentation

open access: yesAdvanced Science, EarlyView.
A 3D‑printed multilayer adhesive scaffold, firmly anchored to bone defects by simple finger pressing, suppresses micromotion and secures mechanical stability of the osteogenic niche. This stabilization likely contributes to the enhanced bone augmentation by fostering a pro‑regenerative mechano‐immune profile—characterized by M2‑like macrophage ...
Delu Zhao   +7 more
wiley   +1 more source

Optimal Shape and Boil-Off Gas Generation of Fuel Tank for LNG Fueled Tugboat

open access: yes한국해양공학회지, 2020
This paper proposes the optimal shape of an LNG fuel tank with a lattice pressure vessel (LPV) design for a tugboat. The LPV is a Type C tank with a design philosophy of “design by analysis,” which facilitates greater variability of shape compared with ...
Jung-Woog Kim   +2 more
doaj   +1 more source

Biochemically Constrained Multi‐Omics Integration Reveals Protein–Metabolite Dependencies Across Diseases

open access: yesAdvanced Science, EarlyView.
ProMetNet introduces a biologically constrained deep learning framework for proteo‐metabolomic integration by embedding Reactome‐derived pathway topology into neural networks. It captures non‐linear molecular dependencies and pathway‐level metabolic reorganization, enabling interpretable discrimination.
Minghui Zhao   +6 more
wiley   +1 more source

Impact of Acute Functional Decline on Frailty and Mortality in Acutely Hospitalized Older Persons

open access: yesAGING MEDICINE, EarlyView.
Older persons with acute functional decline are often severely frail. Male sex, cognitive impairment, diabetes mellitus type 2, cancer, hearing impairment, and nursing home living increase the risk of severe frailty or death and should be considered when person‐centered care is planned for hospitalized older people.
Ali Vahedi   +5 more
wiley   +1 more source

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