Results 51 to 60 of about 1,326 (158)

Molecular imaging of multiple sclerosis: from the clinical demand to novel radiotracers

EJNMMI Radiopharmacy and Chemistry, 2019
Background Brain PET imaging with different tracers is mainly clinically used in the field of neurodegenerative diseases and brain tumors. In recent years, the potential usefulness of PET has also gained attention in the field of MS.
Matteo Bauckneht, Selene Capitanio, Stefano Raffa, Luca Roccatagliata, Matteo Pardini, Caterina Lapucci, Cecilia Marini, Gianmario Sambuceti, Matilde Inglese, Paolo Gallo, Diego Cecchin, Flavio Nobili, Silvia Morbelli   +12 more
doaj   +1 more source

Advanced Imaging Applications in Tumefactive Demyelination – Literature Review With an Illustrative Case Report

Clinical Neuroimaging, Volume 3, Issue 1, 2026.
ABSTRACT Background and Purpose Solitary tumefactive demyelinating lesions (TDLs) represent an uncommon but clinically significant manifestation of central nervous system demyelination and pose a major diagnostic challenge due to their radiologic resemblance to high‐grade gliomas, primary central nervous system lymphoma, and other mass‐like lesions ...
Joga Chaganti, Michelle Dellalana, Kiran Talekar, Jay Thakkar, Scott H. Faro   +4 more
wiley   +1 more source

The Associations Between Chronic Active Lesions and White Matter Disease: A 7 Tesla Imaging Study

Annals of Clinical and Translational Neurology, Volume 12, Issue 12, Page 2535-2545, December 2025.
ABSTRACT Background The relationship between paramagnetic rim lesions (PRLs) and surrounding normally appearing white matter (NAWM) disease, potentially contributory to the associations seen between PRLs and clinical impairment, is underexplored. Objectives To assess whether PRLs correlate with a greater degree of NAWM injury in early MS.
Ellie McCluey, Ahmad A. Toubasi, Jiacheng Wang, Habeeb F. Kazimuddin, Taegan Vinarsky, Caroline Gheen, Carynn Koch, Zachery Rohm, Bryan Hernandez, Margareta A. Clarke, Rachael Cheek, Rozita Khalili, Chaoyang Jin, Victoria Lim, John Kramer, Junzhong Xu, Ipek Oguz, Francesca Bagnato   +17 more
wiley   +1 more source

Neuroimaging of tumefactive multiple sclerosis with atypical features

Radiology Case Reports, 2012
Tumefactive demyelinating lesions or tumefactive multiple sclerosis (TMS) constitute a unique presentation of demyelinating disease that frequently mimics intracranial neoplasm, infection or other, nondemyelinating intracranial pathology. Consequently, these lesions, which are larger than typical multiple sclerosis plaques and are generally ...
Koppula, Rohit, Degnan, Andrew J., Ghassibi, Mark, Duggan, Peter, Jones, Robert, Levy, Lucien M.   +5 more
openaire   +2 more sources

A Case of Multiple Sclerosis Presenting with Tumefactive Lesions

Journal of Multiple Sclerosis and Neuroimmunology, 2023
Inflammatory demyelinating diseases including multiple sclerosis (MS) are usually diagnosed based on characteristic clinical and radiological findings. However, some demyelinating diseases have presented with growing large mass-like lesions, and it is difficult to differentiate those demyelinating lesions from brain tumors.
Yu-jin Kang, Sang-Gon Lee, Suk-Won Ahn
openaire   +1 more source

Longitudinal Brain Atrophy Patterns in Early MOG‐Antibody Associated Disease and Relapsing Multiple Sclerosis

European Journal of Neurology, Volume 32, Issue 11, November 2025.
ABSTRACT Background Myelin oligodendrocyte glycoprotein antibody‐associated disease can manifest as a relapsing or monophasic condition. Although several MRI studies have shown evident gray and white matter atrophy compared to healthy controls, little is known about regional brain volume dynamics in myelin oligodendrocyte glycoprotein antibody ...
Theodoros Ladopoulos, David Bratek, Carolin Schwake, Ann‐Kathrin Kogel, Barbara Bellenberg, Britta Krieger, Zainab Abbas, Ralf Gold, Carsten Lukas, Ilya Ayzenberg, Ruth Schneider   +10 more
wiley   +1 more source

Tumefactive Demyelinating Lesion Induced by Infliximab in a Patient With Rheumatoid Arthritis: A Case Report

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Tumor Necrosis Factor‐alpha (TNF‐α) inhibitors have been successfully used to treat rheumatoid arthritis (RA), psoriatic and ankylosing arthritis, and inflammatory bowel disease. While these inhibitors effectively decrease the inflammatory activity of immune‐related disorders, they have been associated with central nervous system (CNS) and ...
Shahla Mohammed Saeed Rasul, Zana Abdulrahman Mohammed, Aran Asaad Adiban, Yahya Jawad Kadhm   +3 more
wiley   +1 more source

The effect of ocrelizumab on Balo's tumefactive lesion: A case report

Radiology Case Reports
Balo's concentric sclerosis (BCS) is a rare subtype of multiple sclerosis. Advanced MRI metrics, such as magnetization transfer ratio (MTR), fractional anisotropy (FA), mean diffusivity (MD), and the ratio of total N-acetylaspartate concentration/total ...
Muhammad Faraz Raghib, MD, Fen Bao, MS, Sophia Tessema, MD, Carla Santiago Martinez, MS, Jacob Rube, MD, Evanthia Bernitsas, MD   +5 more
doaj   +1 more source

Role of Therapeutic Plasma Exchange in Treatment of Tumefactive Multiple Sclerosis-Associated Low CD4 and CD8 Levels

Case Reports in Neurology, 2016
We report a 35-year-old healthy male who developed central nervous system inflammatory demyelinating disease consistent with tumefactive multiple sclerosis.
Kristen Lew, Nishith Mewada, Sahana Ramanujam, Bahareh Hassanzadeh, John E. Donahue, Leema Reddy Peddareddygari, Robert Moser, Charles  Kososky, Raji P. Grewal   +8 more
doaj   +1 more source

Recurrent Fulminant Tumefactive Demyelination With Marburg-Like Features and Atypical Presentation: Therapeutic Dilemmas and Review of Literature

Frontiers in Neurology, 2020
Atypical forms of demyelinating diseases with tumor-like lesions and aggressive course represent a diagnostic and therapeutic challenge for neurologists.
Aigli G. Vakrakou, Dimitrios Tzanetakos, Theodore Argyrakos, Georgios Koutsis, Maria-Eleptheria Evangelopoulos, Elisabeth Andreadou, Maria Anagnostouli, Marianthi Breza, John S. Tzartos, Elias Gialafos, Antonios N. Dimitrakopoulos, Georgios Velonakis, Panagiotis Toulas, Leonidas Stefanis, Constantinos Kilidireas   +14 more
doaj   +1 more source