Results 61 to 70 of about 1,326 (158)

Neuromyelitis Optica Mimicking Multiple Sclerosis: A Case Report and a Comprehensive Review of the Literature

Clinical Case Reports, Volume 13, Issue 10, October 2025.
Post‐gadolinium enhancement of the spinal cord seen in NMO. ABSTRACT Neuromyelitis optica spectrum disorder (NMOSD) may mimic other neurological conditions, including multiple sclerosis (MS). We report a 25‐year‐old woman with hypothyroidism and depression who presented with progressive quadriparesis.
Sunil Thatal, Susmin Karki, Asmita Parajuli, Sweta Bhandari, Bibek K. C., Dibasha Adhikari, Navin Kumar Sah   +6 more
wiley   +1 more source

Tumefactive multiple sclerosis requiring emergent biopsy and histological investigation to confirm the diagnosis: a case report

Journal of Medical Case Reports, 2012
Introduction Tumefactive multiple sclerosis is a demyelinating disease that demonstrates tumor-like features on magnetic resonance imaging. Although diagnostic challenges without biopsy have been tried by employing radiological studies and cerebrospinal ...
Yamada So, Yamada Shoko, Nakaguchi Hiroshi, Murakami Mineko, Hoya Katsumi, Matsuno Akira, Yamazaki Kazuto, Ishida Yasuo   +7 more
doaj   +1 more source

IgG4‐Related Disease: Emerging Roles of Novel Genetic Variants, Immune Cell Subsets and Therapeutic Targets

Allergy, Volume 80, Issue 10, Page 2738-2754, October 2025.
ABSTRACT IgG4, the least abundant IgG subclass in humans, is increasingly recognised for its involvement in allergic and autoimmune pathologies. Its unique properties, such as the tendency to form half‐molecules (one heavy chain and one light chain) and its generally non‐inflammatory nature, distinguish it from other IgG subclasses.
Louisa Tedesco, Syed B. Ali, Baran Erman, Safa Baris, Harshita Pant, Pravin Hissaria, Yelda Bilginer, Damon J. Tumes, Gökhan Cildir   +8 more
wiley   +1 more source

Stroke Mimicry: Unmasking a Brainstem Tuberculoma in a Young Patient

Clinical Case Reports, Volume 13, Issue 9, September 2025.
A young male presented with stroke‐like symptoms ‐ progressive hemiparesis and cranial nerve palsies. MRI brain revealed a ring‐enhancing intrapontine lesion with perilesional edema, suggestive of tuberculoma. Early initiation of anti‐tubercular therapy led to complete recovery.
Nithish Nanda Palanisamy, Dhiran Sivasubramanian, Virushnee Senthilkumar, Smrti Aravind, Sathwik Sanil, Karthick Balasubramanian   +5 more
wiley   +1 more source

A case of retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations

Radiology Case Reports
Retinal vasculopathy with cerebral leukoencephalopathy (RVCL) is an autosomal dominant disorder caused by mutations in the TREX1 gene, which affects medium and small arteries and veins. Reported in fewer than 50 families worldwide, RVCL typically affects
Musharaf Khan, DO, Subtain Ali, MD, Bushra Sayeed, MD, Eyassu Hailemichael, MD, Dhairya A. Lakhani, MD   +4 more
doaj   +1 more source

Multiple Sclerosis and Oligodendroglioma: An Exceptional Association

Case Reports in Neurological Medicine, 2014
The cooccurrence of multiple sclerosis (MS) and oligodendroglioma is very rare. We present a 43-year-old male patient with the diagnosis of MS lasting for 14 years who developed seizures and right hemiparesis; cerebral MRI revealed an already known ...
Ana Teresa Carvalho, Paulo Linhares, Lígia Castro, Maria José Sá   +3 more
doaj   +1 more source

Factors for Rituximab Refractoriness in AQP4‐IgG+ NMOSD: A Cohort Study

Annals of Clinical and Translational Neurology, Volume 12, Issue 8, Page 1566-1574, August 2025.
ABSTRACT Objective Neuromyelitis optica spectrum disorder (NMOSD) is a severe autoimmune condition of the central nervous system (CNS), often associated with aquaporin‐4 antibodies (AQP4‐IgG). Rituximab, a CD20+ B‐cell depleting monoclonal antibody, is widely used as first‐line therapy.
Mariano Marrodan, María A. Piedrabuena, María A. Zarate, Sofía Rodríguez Murúa, Ezequiel I. Surace, Mauricio F. Farez, Marcela P. Fiol, María C. Ysrraelit, Jorge Correale   +8 more
wiley   +1 more source

Tumefactive demyelinating disease with isolated spinal cord involvement

Acta Radiologica Short Reports, 2014
Tumefactive multiple sclerosis (TMS) is an unusual variant of demyelinating disease. TMS has a variable and unknown progression and presents with features similar to a neoplasm making the determination a diagnostic challenge to clinicians.
Mina S Makary, Claudia F Kirsch
doaj   +1 more source

7 Tesla MRI in Multiple Sclerosis: Insights From Its Use in Clinical Routine

European Journal of Neurology, Volume 32, Issue 8, August 2025.
Insights from the impact of 7T MRI in routine clinical care in patients with not yet clearly defined neuro‐inflammatory disorders of the central nervous system or in MS patients with uncertainties during routine clinical care. ABSTRACT Background 7 Tesla (7 T) magnetic resonance imaging (MRI) offers higher spatial resolution and signal‐to‐noise ratio ...
A. León Betancourt, F. Messmer, A. Chan, R. Wiest, G. Bonanno, M. Capiglioni, R. Hoepner, F. Wagner, H. Hammer, P. Radojewski   +9 more
wiley   +1 more source

Clinical impact and safety of brain biopsy in unexplained central nervous system disorders: a real‐world cohort study

Annals of Clinical and Translational Neurology, Volume 12, Issue 4, Page 792-804, April 2025.
Abstract Objective A substantial part of central nervous system (CNS) disorders remains unexplained, despite various new and minimally invasive diagnostic techniques. Within this rapidly developing diagnostic field, the precise role of brain biopsy is unknown.
Robin W. van Steenhoven, Saan Salih, Juna M. de Vries, Ide Smets, Rob M. Verdijk, Mayke Gardeniers, Jeroen Kerstens, Juliette Brenner, Yvette S. Crijnen, Marjolein Geurts, Jacoline E. C. Bromberg, Corine H. GeurtsvanKessel, Peter A. E. Sillevis Smitt, Rutger K. Balvers, Maarten J. Titulaer   +14 more
wiley   +1 more source