Results 41 to 50 of about 4,085 (186)

Development and Validation of a LC‐MS/MS Method for Ripretinib and Its Metabolite: Example of a Journey From Laboratory Bench to Routine Application With a Greenness Assessment

Biomedical Chromatography, Volume 39, Issue 9, September 2025.
ABSTRACT Therapeutic drug monitoring of protein kinase inhibitors is widely practiced worldwide. Based on the example of ripretinib dosage requested by a clinician, we detailed the process of method development, using a literature‐based approach while ensuring the sustainability of the method to be as environmentally friendly as possible.
Cedric Rakotovao, Ahmad Sharanek, Audrey Burban, Paul Gueroue, Stéphane Bouchet, Guillaume Bouguéon, Dominique Ducint, Mathieu Molimard, Antoine Italiano, Sarah Djabarouti, Joris Guyon   +10 more
wiley   +1 more source

Forme pseudotumorale de la tuberculose: à propos d'un cas

The Pan African Medical Journal, 2017
La tuberculose osseuse peut prendre l'aspect d'une tumeur maligne. Nous présentons le cas d'un enfant de 4 ans porteur d'une tuberculose osseuse ayant simulé un ostéosarcome fémoral. Le diagnostic a été redressé par l'étude anatomopathologique.
Tarik Salama, El Mohtadi Aghoutane, Redouane El Fezzazi   +2 more
doaj   +1 more source

Atypical Gamma‐Delta‐Positive T‐Cell Lymphoproliferation With Clinical Features of Lymphomatoid Papulosis in Three Children

JEADV Clinical Practice, Volume 4, Issue 4, Page 883-886, September 2025.
Capsule summary We report three paediatric patients with indolent gamma‐delta lymphoproliferation, with a relapsing‐remitting course evoking LyP. Skin biopsies revealed CD8+ and/or CD4+ T cells, without large CD30+ cells, with conserved expression of CD7 and the expression of at least one cytotoxic marker.
Lachance Madeleine, Ram‐Wolff Caroline, Delisle Bernard, Sigg Nina, Bataille Pauline, Bourrat Emmanuelle, Dumont Maëlle, Battesti Gilles, Bozonnat Alizée, Louveau Baptiste, Mourah Samia, Moins‐Teisserenc Hélène, Bagot Martine, Lamant Laurence, Croue Anne, Michalak Sophie, BAH Ismael, Kempf Werner, Battistella Maxime, De Masson Adèle   +19 more
wiley   +1 more source

Un hémangiome intraosseux localement agressif de siège inhabituel

The Pan African Medical Journal, 2019
L'hémangiome osseux est une lésion primitive bénigne de l'os, caractérisée par la néoformation et l'agglomération de vaisseaux sanguins anormaux. L'atteinte des vertèbres et du squelette cranio-facial est la plus fréquente mais, tous les os peuvent être ...
Faten Limaïem
doaj   +1 more source

Adverse Physical Health Outcomes and Healthcare Service Utilization in Siblings of Children With Cancer: A Systematic Review

Cancer Medicine, Volume 14, Issue 15, August 2025.
ABSTRACT Introduction Siblings of children with cancer may be vulnerable to compromised long‐term health. We aimed to describe the frequency (prevalence, incidence) of adverse physical health outcomes and healthcare service utilization among siblings of children with cancer and compare the risk of the above outcomes to siblings of children without ...
Victorine Sirveaux, Lily Puterman‐Salzman, Yue Qian Zhang, Eleni Sotirakos, Philippe Dodin, Guillaume Dumas, Eyal Cohen, Nadia Roumeliotis, Petros Pechlivanoglou, Hallie Coltin   +9 more
wiley   +1 more source

Venetoclax in the Therapeutic Strategy for BPDCN Management

eJHaem, Volume 6, Issue 4, August 2025.
ABSTRACT Background Venetoclax, a B‐cell lymphoma 2 (BCL‐2) inhibitor, is a promising treatment for blastic plasmacytoid dendritic cell neoplasm (BPDCN) and is currently under evaluation in clinical trials. However, several case reports have reported relapses after prolonged treatment, and development of resistance.
Margaux Poussard, Maxime Fredon, Imane Belakri, Sabeha Biichle, Florian Renosi, Evan Seffar, Morgane Boichut, Romain Boidot, Elodie Bôle‐Richard, Francis Bonnefoy, Marie Kroemer, Sophie Bonnot‐Perrin, Philippe Saas, Olivier Adotévi, Francine Garnache‐Ottou, Fanny Angelot‐Delettre   +15 more
wiley   +1 more source

Schwannome malin historique de l'avant bras

The Pan African Medical Journal, 2015
Il s'agit d'un jeune homme de 33 ans, sans antécédents pathologiques notables, qui consulte pour une énorme tumeur (A) bourgeonnante et ulcérée de l'avant bras droit évoluant depuis 3 ans. Une biopsie a été faite ayant conclue pour une tumeur nerveuse de
Ismail Hmouri, Mohamed Kharmaz
doaj   +1 more source

Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery

Obesity, Volume 33, Issue 8, Page 1518-1528, August 2025.
Abstract Objective Fat taste sensitivity has been implicated in long‐term weight loss after bariatric surgery. Unexpectedly, improvement of orosensory fat acuity was not systematic in operated patients. Methods Obesity‐induced alterations of gene expression in gustatory papillae having been recently reported, we have explored the fungiform ...
Arnaud Bernard, Corentin Richard, Loredana Radoi, Romain Boidot, Séverine Ledoux, Philippe Besnard   +5 more
wiley   +1 more source

Améloblastome du sinus maxillaire traité par radiothérapie

The Pan African Medical Journal, 2017
LAmeloblastoma of the maxillary sinus treated with radiation therapyaméloblastome est une tumeur odontogène bénigne à caractère agressif qui nécessite un diagnostic précoce et un traitement adéquat.
Asmaa Chehal, Rosabel Lobo, Asmaa Naim, Ignacio Azinovic   +3 more
doaj   +1 more source

Circumventing glioblastoma resistance to temozolomide through optimal drug combinations designed by systems pharmacology and machine learning

British Journal of Pharmacology, Volume 182, Issue 16, Page 3726-3743, August 2025.
Background and Purpose Glioblastoma (GBM), the most frequent and aggressive brain tumour in adults, is associated with a dismal prognostic despite intensive treatment involving surgery, radiotherapy and temozolomide (TMZ)‐based chemotherapy. The initial or acquired resistance of GBM to TMZ appeals for precision medicine approaches to the design of ...
Sergio Corridore, Maïté Verreault, Hugo Martin, Thibault Delobel, Cécile Carrère, Ahmed Idbaih, Annabelle Ballesta   +6 more
wiley   +1 more source