Results 41 to 50 of about 6,418,846 (364)
Macrophage Polarization States in the Tumor Microenvironment
International Journal of Molecular Sciences, 2021 The M1/M2 macrophage paradigm plays a key role in tumor progression. M1 macrophages are historically regarded as anti-tumor, while M2-polarized macrophages, commonly deemed tumor-associated macrophages (TAMs), are contributors to many pro-tumorigenic ...
Ava J Boutilier, Sherine F. Elsawa
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Orthopaedic Surgery, 2021 Objectives This study aims to: (i) evaluate the outcome of patients with Harrington class III lesions who were treated according to Harrington classification; (ii) propose a modified surgical classification for Harrington class III lesions; and (iii ...
Ran Wei +6 more
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Gab2 plays a carcinogenic role in ovarian cancer by regulating CrkII
Journal of Ovarian Research, 2023 Objective To detect the expression of Growth factor binding protein 2 associated binding protein 2 (Gab2) and CT10 regulator of kinase II (CrkII) in ovarian cancer and analyze their clinical significance.
Yi Yin +4 more
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Gasdermin E suppresses tumor growth by activating anti-tumor immunity
Nature, 2020 Cleavage of the gasdermin proteins to produce pore-forming amino-terminal fragments causes inflammatory cell death (pyroptosis)1. Gasdermin E (GSDME, also known as DFNA5)—mutated in familial ageing-related hearing loss2—can be cleaved by caspase 3 ...
Zhibin Zhang +13 more
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Research Advances in Antitumor Mechanism of Evodiamine
Journal of Chemistry, 2022 Evodiamine is a natural alkaloid extracted from Fructus Evodia. This bioactive alkaloid has been reported to have a wide range of biological activities, including anti-injury, antiobesity, vasodilator, and anti-inflammatory effects.
Luning Li +5 more
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Superior sulcus tumors (Pancoast tumors) [PDF]
Annals of Translational Medicine, 2016 Superior Sulcus Tumors, frequently termed as Pancoast tumors, are a wide range of tumors invading the apical chest wall. Due to its localization in the apex of the lung, with the potential invasion of the lower part of the brachial plexus, first ribs, vertebrae, subclavian vessels or stellate ganglion, the superior sulcus tumors cause characteristic ...
Marulli, Giuseppe +4 more
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Journal of Orthopaedics and Traumatology, 2022 Background Improved patient and limb survival rates have led to an increased interest in the functional outcome and return to sports of patients undergoing megaprosthetic reconstruction in musculoskeletal oncology.
Moritz Ellerbrock +6 more
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Nivolumab plus Ipilimumab in Lung Cancer with a High Tumor Mutational Burden
New England Journal of Medicine, 2018 BACKGROUND Nivolumab plus ipilimumab showed promising efficacy for the treatment of non–small‐cell lung cancer (NSCLC) in a phase 1 trial, and tumor mutational burden has emerged as a potential biomarker of benefit.
M. Hellmann +23 more
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The Tumor Microenvironment Innately Modulates Cancer Progression.
Cancer Research, 2019 Cancer development and progression occurs in concert with alterations in the surrounding stroma. Cancer cells can functionally sculpt their microenvironment through the secretion of various cytokines, chemokines, and other factors.
D. Hinshaw, L. Shevde
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Tumor neoantigens and tumor immunotherapies
AGING MEDICINEAbstractAs a high‐risk group of patients with cancer, the elderly exhibit limited efficacy with traditional treatments. Immunotherapy emerges as a promising adjunctive therapeutic approach that holds potential in addressing the needs of geriatric patients with cancer.
Wang Jiani, Tan Qin, Ma Jie
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