Results 1 to 10 of about 15,400,316 (399)

The PPARγ Agonist Rosiglitazone Suppresses Syngeneic Mouse SCC (Squamous Cell Carcinoma) Tumor Growth through an Immune-Mediated Mechanism [PDF]

, 2019
Recent evidence suggests that PPARγ agonists may promote anti-tumor immunity. We show that immunogenic PDV cutaneous squamous cell carcinoma (CSCC) tumors are rejected when injected intradermally at a low cell number (1 × 106) into immune competent ...
Derr-Yellin, Ethel, Ermatov, Nurmukambed, Konger, Raymond L., Ren, Lu, Sahu, Ravi P.   +4 more
core   +3 more sources

Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer [PDF]

, 2013
Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also
A Ho-Pun-Cheung, A Merlo, Ana Maria Waaga-Gasser, Andreas Rosenwald, C Loddenkemper, Christoph-Thomas Germer, E Sato, Eva Meier, F Ichihara, FA Sinicrope, FL Greene, H Groux, H Lu, H Suzuki, H Tao, HL Weiner, Igor Tsaur, J Shimizu, JD Fontenot, Jun Li, LM Ebert, M Viguier, Maria Lazariotou, Martin Gasser, Martin Grimm, ME Winerdal, Mia Kim, MJ Sack, N Chaput, N Hiraoka, N Kobayashi, P Correale, P Salama, P Yu, Roman Blaheta, S Hinz, S Ladoire, S Onizuka, T Alvaro, Tanja Grimmig, TL Whiteside, Uwe Heemann, V Karanikas, W Zou, WH Wang, WS Lee   +45 more
core   +17 more sources

Tumor Evolution and Therapeutic Choice Seen through a Prism of Circulating Tumor Cell Genomic Instability

Cells, 2021
Circulating tumor cells (CTCs) provide an accessible tool for investigating tumor heterogeneity and cell populations with metastatic potential. Although an in-depth molecular investigation is limited by the extremely low CTC count in circulation ...
Tala Tayoun, Marianne Oulhen, Agathe Aberlenc, Françoise Farace, Patrycja Pawlikowska   +4 more
doaj   +1 more source

Circulating tumor cells: biology and clinical significance

Signal Transduction and Targeted Therapy, 2021
Circulating tumor cells (CTCs) are tumor cells that have sloughed off the primary tumor and extravasate into and circulate in the blood. Understanding of the metastatic cascade of CTCs has tremendous potential for the identification of targets against ...
Danfeng Lin, Lesang Shen, Meng Luo, Kun Zhang, Jinfan Li, Qi Yang, Fangfang Zhu, Danhong Zhou, Shu Zheng, Yiding Chen, Jiaojiao Zhou   +10 more
semanticscholar   +1 more source

Comprehensive liquid biopsy analysis as a tool for the early detection of minimal residual disease in breast cancer

Scientific Reports, 2023
Liquid biopsy (LB) provides a unique minimally invasive tool to follow-up cancer patients over time, to detect minimal residual disease (MRD), to study metastasis-biology and mechanisms of therapy-resistance.
Dimitra Stergiopoulou, Athina Markou, Areti Strati, Martha Zavridou, Eleni Tzanikou, Sophia Mastoraki, Galatea Kallergi, Vassilis Georgoulias, Evi Lianidou   +8 more
doaj   +1 more source

Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives

Molecular Cancer, 2021
Cancer-associated fibroblasts (CAFs), a stromal cell population with cell-of-origin, phenotypic and functional heterogeneity, are the most essential components of the tumor microenvironment (TME).
Xiaoqi Mao, Jin Xu, Wei Wang, Chen Liang, J. Hua, Jiang Liu, Bo Zhang, Qingcai Meng, Xianjun Yu, S. Shi   +9 more
semanticscholar   +1 more source

RNA-Based CTC Analysis Provides Prognostic Information in Metastatic Breast Cancer

Diagnostics, 2021
In metastatic breast cancer (MBC) the molecular characterization of circulating tumor cells (CTCs) provides a unique tool to understand metastasis-biology and therapy-resistance.
Areti Strati, Michail Nikolaou, Vassilis Georgoulias, Evi S. Lianidou   +3 more
doaj   +1 more source

MicroRNA analysis of Natural Killer cell-derived exosomes: the microRNA let-7b-5p is enriched in exosomes and participates in their anti-tumor effects against pancreatic cancer cells

OncoImmunology, 2023
Natural Killer (NK) cells are important components of the immune system in the defense against tumor growth and metastasis. They release exosomes containing proteins and nucleic acids, including microRNAs (miRNAs).
Anna Laura Di Pace, Andrea Pelosi, Piera Filomena Fiore, Nicola Tumino, Francesca Besi, Linda Quatrini, Silvia Santopolo, Paola Vacca, Lorenzo Moretta   +8 more
doaj   +1 more source

The Effect of Genomic DNA Contamination on the Detection of Circulating Long Non-Coding RNAs: The Paradigm of MALAT1

Diagnostics, 2021
The presence of contaminating gDNA in RNA preparations is a frequent cause of false positives in RT-PCR-based analysis. However, in some cases, this cannot be avoided, especially when there are no exons–intron junctions in the lncRNA sequences.
Athina N. Markou, Stavroula Smilkou, Emilia Tsaroucha, Evi Lianidou   +3 more
doaj   +1 more source

KMT2C promoter methylation in plasma‐circulating tumor DNA is a prognostic biomarker in non‐small cell lung cancer

Molecular Oncology, 2021
MLL3 histone methyltransferase, encoded by the KMT2C gene, is a tumor suppressor that has an essential role in cell‐type‐specific gene expression.
Sofia Mastoraki, Ioanna Balgkouranidou, Emily Tsaroucha, Apostolos Klinakis, Vassilis Georgoulias, Evi Lianidou   +5 more
doaj   +1 more source