Results 1 to 10 of about 3,166,261 (352)

Expression of Foxp3 in colorectal cancer but not in Treg cells correlates with disease progression in patients with colorectal cancer [PDF]

, 2013
Background: Regulatory T cells (Treg) expressing the transcription factor forkhead-box protein P3 (Foxp3) have been identified to counteract anti-tumor immune responses during tumor progression. Besides, Foxp3 presentation by cancer cells itself may also
A Ho-Pun-Cheung, A Merlo, Ana Maria Waaga-Gasser, Andreas Rosenwald, C Loddenkemper, Christoph-Thomas Germer, E Sato, Eva Meier, F Ichihara, FA Sinicrope, FL Greene, H Groux, H Lu, H Suzuki, H Tao, HL Weiner, Igor Tsaur, J Shimizu, JD Fontenot, Jun Li, LM Ebert, M Viguier, Maria Lazariotou, Martin Gasser, Martin Grimm, ME Winerdal, Mia Kim, MJ Sack, N Chaput, N Hiraoka, N Kobayashi, P Correale, P Salama, P Yu, Roman Blaheta, S Hinz, S Ladoire, S Onizuka, T Alvaro, Tanja Grimmig, TL Whiteside, Uwe Heemann, V Karanikas, W Zou, WH Wang, WS Lee   +45 more
core   +20 more sources

Tumor Evolution and Therapeutic Choice Seen through a Prism of Circulating Tumor Cell Genomic Instability

Cells, 2021
Circulating tumor cells (CTCs) provide an accessible tool for investigating tumor heterogeneity and cell populations with metastatic potential. Although an in-depth molecular investigation is limited by the extremely low CTC count in circulation ...
Tala Tayoun, Marianne Oulhen, Agathe Aberlenc, Françoise Farace, Patrycja Pawlikowska   +4 more
doaj   +1 more source

Comprehensive liquid biopsy analysis as a tool for the early detection of minimal residual disease in breast cancer

Scientific Reports, 2023
Liquid biopsy (LB) provides a unique minimally invasive tool to follow-up cancer patients over time, to detect minimal residual disease (MRD), to study metastasis-biology and mechanisms of therapy-resistance.
Dimitra Stergiopoulou, Athina Markou, Areti Strati, Martha Zavridou, Eleni Tzanikou, Sophia Mastoraki, Galatea Kallergi, Vassilis Georgoulias, Evi Lianidou   +8 more
doaj   +1 more source

RNA-Based CTC Analysis Provides Prognostic Information in Metastatic Breast Cancer

Diagnostics, 2021
In metastatic breast cancer (MBC) the molecular characterization of circulating tumor cells (CTCs) provides a unique tool to understand metastasis-biology and therapy-resistance.
Areti Strati, Michail Nikolaou, Vassilis Georgoulias, Evi S. Lianidou   +3 more
doaj   +1 more source

MicroRNA analysis of Natural Killer cell-derived exosomes: the microRNA let-7b-5p is enriched in exosomes and participates in their anti-tumor effects against pancreatic cancer cells

OncoImmunology, 2023
Natural Killer (NK) cells are important components of the immune system in the defense against tumor growth and metastasis. They release exosomes containing proteins and nucleic acids, including microRNAs (miRNAs).
Anna Laura Di Pace, Andrea Pelosi, Piera Filomena Fiore, Nicola Tumino, Francesca Besi, Linda Quatrini, Silvia Santopolo, Paola Vacca, Lorenzo Moretta   +8 more
doaj   +1 more source

The Effect of Genomic DNA Contamination on the Detection of Circulating Long Non-Coding RNAs: The Paradigm of MALAT1

Diagnostics, 2021
The presence of contaminating gDNA in RNA preparations is a frequent cause of false positives in RT-PCR-based analysis. However, in some cases, this cannot be avoided, especially when there are no exons–intron junctions in the lncRNA sequences.
Athina N. Markou, Stavroula Smilkou, Emilia Tsaroucha, Evi Lianidou   +3 more
doaj   +1 more source

KMT2C promoter methylation in plasma‐circulating tumor DNA is a prognostic biomarker in non‐small cell lung cancer

Molecular Oncology, 2021
MLL3 histone methyltransferase, encoded by the KMT2C gene, is a tumor suppressor that has an essential role in cell‐type‐specific gene expression.
Sofia Mastoraki, Ioanna Balgkouranidou, Emily Tsaroucha, Apostolos Klinakis, Vassilis Georgoulias, Evi Lianidou   +5 more
doaj   +1 more source

Analysis of the mechanisms regulating soluble PD-1 production and function in human NK cells

Frontiers in Immunology, 2023
NK cells represent important effectors that play a major role in innate defences against pathogens and display potent cytolytic activity against tumor cells. An array of surface receptors finely regulate their function and inhibitory checkpoints, such as
Francesca Romana Mariotti, Tiziano Ingegnere, Nadine Landolina, Nadine Landolina, Paola Vacca, Enrico Munari, Lorenzo Moretta   +6 more
doaj   +1 more source

A Quantitative Modular Modeling Approach Reveals the Effects of Different A20 Feedback Implementations for the NF-kB Signaling Dynamics

Frontiers in Physiology, 2020
Signaling pathways involve complex molecular interactions and are controled by non-linear regulatory mechanisms. If details of regulatory mechanisms are not fully elucidated, they can be implemented by different, equally reasonable mathematical ...
Janina Mothes, Inbal Ipenberg, Seda Çöl Arslan, Uwe Benary, Claus Scheidereit, Jana Wolf   +5 more
doaj   +1 more source

Gene expression in circulating tumor cells reveals a dynamic role of EMT and PD-L1 during osimertinib treatment in NSCLC patients

Scientific Reports, 2021
Liquid biopsy is a tool to unveil resistance mechanisms in NSCLC. We studied changes in gene expression in CTC-enriched fractions of EGFR-mutant NSCLC patients under osimertinib.
Aliki Ntzifa, Areti Strati, Galatea Kallergi, Athanasios Kotsakis, Vassilis Georgoulias, Evi Lianidou   +5 more
doaj   +1 more source