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Tumor Hypoxia and Circulating Tumor Cells [PDF]
International Journal of Molecular Sciences, 2020 Circulating tumor cells (CTCs) are a rare tumor cell subpopulation induced and selected by the tumor microenvironment’s extreme conditions. Under hypoxia and starvation, these aggressive and invasive cells are able to invade the lymphatic and circulatory systems.
Tinganelli W., Durante M.
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Cells, 2021 Circulating tumor cells (CTCs) provide an accessible tool for investigating tumor heterogeneity and cell populations with metastatic potential. Although an in-depth molecular investigation is limited by the extremely low CTC count in circulation ...
Tala Tayoun +4 more
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RNA-Based CTC Analysis Provides Prognostic Information in Metastatic Breast Cancer
Diagnostics, 2021 In metastatic breast cancer (MBC) the molecular characterization of circulating tumor cells (CTCs) provides a unique tool to understand metastasis-biology and therapy-resistance.
Areti Strati +3 more
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Scientific Reports, 2023 Liquid biopsy (LB) provides a unique minimally invasive tool to follow-up cancer patients over time, to detect minimal residual disease (MRD), to study metastasis-biology and mechanisms of therapy-resistance.
Dimitra Stergiopoulou +8 more
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Molecular Oncology, 2017 Metastasis is the primary cause of death in cancer patients and current treatments fail to provide durable responses. Efforts to treat metastatic disease are hindered by the fact that metastatic cells often remain dormant for prolonged intervals of years, or even decades.
Gomis i Cabré, Roger, Gawrzak, Sylwia
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OncoImmunology, 2023 Natural Killer (NK) cells are important components of the immune system in the defense against tumor growth and metastasis. They release exosomes containing proteins and nucleic acids, including microRNAs (miRNAs).
Anna Laura Di Pace +8 more
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T cells in tumor microenvironment [PDF]
Tumor Biology, 2015 Tumors progress in a specific area, which supports its development, spreading or shrinking in time with the presence of different factors that effect the fate of the cancer cells. This specialized site is called "tumor microenvironment" and has a composition of heterogenous materials.
Yağmur Kiraz +4 more
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Diagnostics, 2021 The presence of contaminating gDNA in RNA preparations is a frequent cause of false positives in RT-PCR-based analysis. However, in some cases, this cannot be avoided, especially when there are no exons–intron junctions in the lncRNA sequences.
Athina N. Markou +3 more
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Molecular Oncology, 2021 MLL3 histone methyltransferase, encoded by the KMT2C gene, is a tumor suppressor that has an essential role in cell‐type‐specific gene expression.
Sofia Mastoraki +5 more
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Analysis of the mechanisms regulating soluble PD-1 production and function in human NK cells
Frontiers in Immunology, 2023 NK cells represent important effectors that play a major role in innate defences against pathogens and display potent cytolytic activity against tumor cells. An array of surface receptors finely regulate their function and inhibitory checkpoints, such as
Francesca Romana Mariotti +6 more
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