Results 221 to 230 of about 15,304,481 (401)

Circulating tumor cells as a recurrence risk marker in glioma: a retrospective study. [PDF]

Transl Cancer Res
Huang X, Guo J, Cui Y, Liang J, Cheng N, Zhang Y, He D.   +6 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells. [PDF]

Nat Commun
Son SW, Lee HJ, Kang N, Bae S, Cho E, Kwon H, Yoon DY, Lee C, Lee S, Son MK, Chae J, Kim S, Oh SJ, Sim Y, Lee KM, Yee C, Woo SR, Jeong YJ, Choi HJ, Kwak JY, Lee EW, Park J, Kwak SG, Chang YC, Kim TW, Song KH.   +25 more
europepmc   +1 more source

Epigenetic Remodeling through Downregulation of Polycomb Repressive Complex 2 Mediates Chemotherapy Resistance in Testicular Germ Cell Tumors [PDF]

, 2019
Ratnakar Singh, Zeeshan Fazal, Andrea Corbet, Emmanuel Bikorimana, Jennifer Rodriguez, Ema M Khan, Khadeeja Shahid, Sarah J. Freemantle, Michael J. Spinella   +8 more
openalex   +1 more source

A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy

Molecular Oncology, EarlyView.
Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti, Giovanni Germano, Pietro Paolo Vitiello, Alberto Bardelli   +3 more
wiley   +1 more source

Fibroblasts Attenuate Anti-Tumor Drug Efficacy in Tumor Cells via Paracrine Interactions with Tumor Cells in 3D Plexiform Neurofibroma Cultures. [PDF]

Cells
Ji K, Schwenkel GJ.
europepmc   +1 more source

Innate and adaptive immune cells in the tumor microenvironment

Nature Immunology, 2013
T. Gajewski, H. Schreiber, yang-xin fu
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Circulating tumor cells: indicators of cancer progression, plasticity and utility for therapies. [PDF]

Pathol Oncol Res
Linkner TR, Nagy ZB, Kalmár A, Farkas E, Bányai F, Szakállas N, Takács I, Molnár B.   +7 more
europepmc   +1 more source

Current detection technologies for circulating tumor cells.

Chemical Society Reviews, 2017
Zheyu Shen, A. Wu, Xiaoyuan Chen
semanticscholar   +1 more source