Results 271 to 280 of about 15,400,316 (399)

DDR2 Confers Ferroptosis Resistance to Cancer-Associated Fibroblasts and Attenuates PARPi Sensitivity of Ovarian Tumor Cells. [PDF]

Mol Cancer Res
Lesage J, DiMauro A, Schab AM, Stidham S, Mullen MM, Fuh KC, Longmore GD.   +6 more
europepmc   +1 more source

Neutrophil extracellular traps sequester circulating tumor cells and promote metastasis.

Journal of Clinical Investigation, 2013
J. Cools-Lartigue, J. Spicer, B. McDonald, S. Gowing, S. Chow, B. Giannias, F. Bourdeau, P. Kubes, L. Ferri   +8 more
semanticscholar   +1 more source

TREX1, a predator for treating MSI‐H tumors?

Molecular Oncology, EarlyView.
Immunotherapy benefits many patients; yet, some with MSI‐H tumors remain unresponsive despite their high immunogenicity. Xu et al. reveal that TREX1 enables immune evasion by degrading cytosolic DNA and suppressing cGAS–STING–IFN‐I signaling. TREX1 loss restores DNA sensing, increases CD8+ T and NK cell infiltration, and boosts antitumor immunity ...
Elena Benidovskaya, Joséphine Deneft, Marc Van den Eynde   +2 more
wiley   +1 more source

In Situ Engineering of Tumor Cells as Self-Sustaining cDC1 Programming Factories for Effective Cancer Immunotherapy. [PDF]

Adv Sci (Weinh)
Jin S, Wang X, Li B, Zhu X, Liu Z, Lu J, Wei Y, Wu Z, Li K, Zhang T, He Z, Zhu P, Qi Y, Liu B, Liu H, Wang Y, Chen Z.   +16 more
europepmc   +1 more source

p53 and p16/p19 Loss Promotes Different Pancreatic Tumor Types from PyMT-Expressing Progenitor Cells

, 2016
Stephanie A. Azzopardi, Sharon Pang, David S. Klimstra, Yi‐Chieh Nancy Du   +3 more
openalex   +1 more source

Inhabitual presentation of Sertoli-Leydig cell tumor of the ovary with xeroderma pigmentosum

, 2020
Ahlem Bdioui, Ahlem Bchir, Nabiha Missaoui, Hajer Hamchi, Sihem Hmissa, Moncef Mokni   +5 more
openalex   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

M2 macrophages and tumor cells engage in a metabolic feedback loop to drive HCC progression. [PDF]

Sci Rep
Nong Y, Chen X, Zhang B, Lin Z, Wuriniletu, Du C, Liu Q.   +6 more
europepmc   +1 more source

Glioblastoma Stem Cells: Conversion or Reprogramming from Tumor Non- Stem Cells?

, 2015
Davide Schiffer, Laura Annovazzi, Paola Cassoni, Maria Consuelo Valentini, Marta Mazzucco, Marta Mellai   +5 more
openalex   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source