Results 281 to 290 of about 15,304,481 (401)

Editorial: Predictive and prognostic value of liquid biopsy biomarkers in metastatic cancers: from basic science, across high throughput profiling up to clinical practice

Frontiers in Oncology
Dorota Kwapisz, Patrycja Pawlikowska, Areti Strati   +2 more
doaj   +1 more source

Isolation of circulating tumor cells using a microvortex-generating herringbone-chip

Proceedings of the National Academy of Sciences of the United States of America, 2010
Shannon L. Stott, Chia-Hsien Hsu, Chiajen Hsu, Chia-Hsien Hsu, D. Tsukrov, Min Yu, D. Miyamoto, B. A. Waltman, S. Rothenberg, Ajay M Shah, Malgorzata E. Smas, George K Korir, Frederick P. Floyd, A. Gilman, Jenna B Lord, D. Winokur, S. Springer, D. Irimia, D. Irimia, S. Nagrath, S. Nagrath, L. Sequist, L. Sequist, R. J. Lee, R. J. Lee, K. Isselbacher, S. Maheswaran, D. Haber, D. Haber, M. Toner, M. Toner   +30 more
semanticscholar   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Synthetic lethality by PARP inhibitors: new mechanism uncovered based on unresolved transcription-replication conflicts

Signal Transduction and Targeted Therapy
Marina Kolesnichenko, Claus Scheidereit
doaj   +1 more source

Relationship of circulating tumor cells to tumor response, progression-free survival, and overall survival in patients with metastatic colorectal cancer.

Journal of Clinical Oncology, 2008
Steven J. Cohen, C. Punt, N. Iannotti, B. Saidman, K. Sabbath, N. Gabrail, J. Picus, M. Morse, E. Mitchell, M. Miller, G. Doyle, H. Tissing, L. Terstappen, Neal J. Meropol   +13 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Postnatal sustentacular cells as chromaffin progenitors and tumor cells of origin in VHL-related paragangliomas. [PDF]

NPJ Precis Oncol
Bullova P, Cui P, Arceo M, Zhu J, Li W, Plescher M, Poltorachenko V, Stripling K, Santangeli C, Mykhaylechko L, Kastriti ME, Larsson C, Juhlin CC, Mints M, Schlisio S.   +14 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

LbL-Antibody Embedded Gold Mesh: An Effective Method for Early Detection of Circulating Tumor Cells. [PDF]

Int J Nanomedicine
Qin R, Ma Z, Song C, Huang C, Zhu Z, Yan J, Wang J.   +6 more
europepmc   +1 more source

Transcriptional Amplification in Tumor Cells with Elevated c-Myc

Cell, 2012
Charles Y. Lin, Jakob Lovén, P. Rahl, Ronald M. Paranal, C. Burge, J. Bradner, Tong Ihn Lee, R. Young   +7 more
semanticscholar   +1 more source