Results 291 to 300 of about 15,304,481 (401)

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Folate receptor-positive circulating tumor cells might function as potential biomarkers for hepatocellular carcinoma. [PDF]

World J Gastrointest Oncol
Zhang ZY, Zhou M, Liu JJ, Zhang W.
europepmc   +1 more source

ADAMTS-1 Is Found in the Nuclei of Normal and Tumoral Breast Cells

, 2016
Suély V. Silva, Maíra A. Lima, Nathalie Cella, Ruy Gastaldoni Jaeger, Vanessa M. Freitas   +4 more
openalex   +2 more sources

Ex vivo culture of circulating breast tumor cells for individualized testing of drug susceptibility

Science, 2014
Min Yu, A. Bardia, N. Aceto, Francesca Bersani, M. W. Madden, M. C. Donaldson, R. Desai, Huili Zhu, Valentine Comaills, Zongli Zheng, Ben S. Wittner, P. Stojanov, E. Brachtel, D. Sgroi, R. Kapur, T. Shioda, D. Ting, Sridhar Ramaswamy, G. Getz, A. Iafrate, C. Benes, M. Toner, S. Maheswaran, D. Haber, D. Haber   +24 more
semanticscholar   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Caught in the Act: Tumor-Immune Interactions in Circulation of Patients with Immune Marker Positive Circulating Tumor Cells. [PDF]

Cancers (Basel)
Naghdloo A, Kamal M, Tessone D, Hennes V, Hicks J, Kuhn P.   +5 more
europepmc   +1 more source

The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment.

Trends in immunology, 2016
Vinit Kumar, Sima Patel, E. Tcyganov, D. Gabrilovich   +3 more
semanticscholar   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Could circulating tumor cells explain why breast conservation improves survival despite higher locoregional recurrence? [PDF]

Transl Breast Cancer Res
Oner M, Mokbel K.
europepmc   +1 more source

Anticancer sensitivities and biological characteristics of HCT116 cells resistant to the selective poly(ADP‐ribose) glycohydrolase inhibitor

FEBS Open Bio, EarlyView.
We analyzed alterations of PAR metabolism‐related proteins in PARG inhibitor‐resistant HCT116RPDD cells. Although PARG levels remained unchanged, HCT116RPDD cells exhibited reduced PARP1 and ARH3 expression and elevated PAR levels. Interestingly, HCT116RPDD cells exhibited slightly elevated intracellular NAD+/NADH and ATP levels. Our findings suggest a
Kaede Tsuda, Yoko Ogino, Akira Sato
wiley   +1 more source